Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ouyang:2020:10.1126/sciadv.abc5529,
author = {Ouyang, L and Armstrong, J and Lin, Y and Wojciechowski, J and Lee-Reeves, C and Hachim, D and Zhou, K and Burdick, JA and Stevens, M},
doi = {10.1126/sciadv.abc5529},
journal = {Science Advances},
pages = {1--13},
title = {Expanding and optimizing 3D bioprinting capabilities using complementary network bioinks},
url = {http://dx.doi.org/10.1126/sciadv.abc5529},
volume = {6},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - A  major  challenge  in  3D  bioprinting  is  the  limited  number  of  bioinks  that  fulfill  the physiochemical requirements of printing, while also providing a desirable environment for encapsulated cells.Here, we address this limitation by temporarily stabilizing bioinks with a complementary thermo-reversible gelatin  network.  This  strategy  enablesthe effective printing   of   biomaterials that would typically   not  meet   printing   requirements,   with instrument parameters  and  structural  output  largely  independent  of  the base biomaterial. This approach is demonstrated across a library of photo-crosslinkable bioinks derived from natural  and  synthetic polymers, including gelatin,  hyaluronic  acid,  chondroitin  sulfate, dextran,  alginate,  chitosan,  heparin,and poly(ethylene  glycol). A range  of  complex  and heterogeneous structures are printed, including soft hydrogel constructs supporting the 3D culture  of astrocytes.  This  highly  generalizable  methodology  expands  the  palette  of available bioinks, allowing the biofabrication of constructs optimized to meet the biological requirements of cell culture and tissue engineering.
AU  - Ouyang,L
AU  - Armstrong,J
AU  - Lin,Y
AU  - Wojciechowski,J
AU  - Lee-Reeves,C
AU  - Hachim,D
AU  - Zhou,K
AU  - Burdick,JA
AU  - Stevens,M
DO  - 10.1126/sciadv.abc5529
EP  - 13
PY  - 2020///
SN  - 2375-2548
SP  - 1
TI  - Expanding and optimizing 3D bioprinting capabilities using complementary network bioinks
T2  - Science Advances
UR  - http://dx.doi.org/10.1126/sciadv.abc5529
UR  - https://advances.sciencemag.org/content/6/38/eabc5529
UR  - http://hdl.handle.net/10044/1/81895
VL  - 6
ER  -
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