Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ahadian:2020:10.1016/j.addr.2020.07.012,
author = {Ahadian, S and Finbloom, JA and Mofidfar, M and Emir, Diltemiz S and Nasrollahi, F and Davoodi, E and Hosseini, V and Mylonaki, I and Sangabathuni, S and Montazerian, H and Fetah, K and Nasiri, R and Remzi, Dokmeci M and Stevens, M and Desai, TA and Khademhosseini, A},
doi = {10.1016/j.addr.2020.07.012},
journal = {Advanced Drug Delivery Reviews},
pages = {37--62},
title = {Micro and nanoscale technologies in oral drug delivery},
url = {http://dx.doi.org/10.1016/j.addr.2020.07.012},
volume = {157},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Oral administration is a pillar of the pharmaceutical industry and yet it remains challenging to administer hydrophilic therapeutics by the oral route. Smart and controlled oral drug delivery could bypass the physiological barriers that limit the oral delivery of these therapeutics. Micro- and nanoscale technologies, with an unprecedented ability to create, control, and measure micro- or nanoenvironments, have found tremendous applications in biology and medicine. In particular, significant advances have been made in using these technologies for oral drug delivery. In this review, we briefly describe biological barriers to oral drug delivery and micro and nanoscale fabrication technologies. Micro and nanoscale drug carriers fabricated using these technologies, including bioadhesives, microparticles, micropatches, and nanoparticles, are described. Other applications of micro and nanoscale technologies are discussed, including the fabrication of devices and tissue engineering models to precisely control or assess oral drug delivery in vivo and in vitro, respectively. Strategies to advance translation of micro and nanotechnologies into clinical trials for oral drug delivery are mentioned. Finally, challenges and future prospects on further integration of micro and nanoscale technologies with oral drug delivery systems are highlighted.
AU  - Ahadian,S
AU  - Finbloom,JA
AU  - Mofidfar,M
AU  - Emir,Diltemiz S
AU  - Nasrollahi,F
AU  - Davoodi,E
AU  - Hosseini,V
AU  - Mylonaki,I
AU  - Sangabathuni,S
AU  - Montazerian,H
AU  - Fetah,K
AU  - Nasiri,R
AU  - Remzi,Dokmeci M
AU  - Stevens,M
AU  - Desai,TA
AU  - Khademhosseini,A
DO  - 10.1016/j.addr.2020.07.012
EP  - 62
PY  - 2020///
SN  - 0169-409X
SP  - 37
TI  - Micro and nanoscale technologies in oral drug delivery
T2  - Advanced Drug Delivery Reviews
UR  - http://dx.doi.org/10.1016/j.addr.2020.07.012
UR  - https://www.sciencedirect.com/science/article/pii/S0169409X2030096X?via%3Dihub
UR  - http://hdl.handle.net/10044/1/81481
VL  - 157
ER  -
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