Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Majid:2020:10.3389/fcvm.2020.554597,
author = {Majid, QA and Fricker, ATR and Gregory, DA and Davidenko, N and Hernandez, Cruz O and Jabbour, RJ and Owen, TJ and Basnett, P and Lukasiewicz, B and Stevens, M and Best, S and Cameron, R and Sinha, S and Harding, SE and Roy, I},
doi = {10.3389/fcvm.2020.554597},
journal = {Frontiers in Cardiovascular Medicine},
pages = {1--32},
title = {Natural biomaterials for cardiac tissue engineering: a highly biocompatible solution.},
url = {http://dx.doi.org/10.3389/fcvm.2020.554597},
volume = {7},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cardiovascular diseases (CVD) constitute a major fraction of the current major global diseases and lead to about 30% of the deaths, i.e., 17.9 million deaths per year. CVD include coronary artery disease (CAD), myocardial infarction (MI), arrhythmias, heart failure, heart valve diseases, congenital heart disease, and cardiomyopathy. Cardiac Tissue Engineering (CTE) aims to address these conditions, the overall goal being the efficient regeneration of diseased cardiac tissue using an ideal combination of biomaterials and cells. Various cells have thus far been utilized in pre-clinical studies for CTE. These include adult stem cell populations (mesenchymal stem cells) and pluripotent stem cells (including autologous human induced pluripotent stem cells or allogenic human embryonic stem cells) with the latter undergoing differentiation to form functional cardiac cells. The ideal biomaterial for cardiac tissue engineering needs to have suitable material properties with the ability to support efficient attachment, growth, and differentiation of the cardiac cells, leading to the formation of functional cardiac tissue. In this review, we have focused on the use of biomaterials of natural origin for CTE. Natural biomaterials are generally known to be highly biocompatible and in addition are sustainable in nature. We have focused on those that have been widely explored in CTE and describe the original work and the current state of art. These include fibrinogen (in the context of Engineered Heart Tissue, EHT), collagen, alginate, silk, and Polyhydroxyalkanoates (PHAs). Amongst these, fibrinogen, collagen, alginate, and silk are isolated from natural sources whereas PHAs are produced via bacterial fermentation. Overall, these biomaterials have proven to be highly promising, displaying robust biocompatibility and, when combined with cells, an ability to enhance post-MI cardiac function in pre-clinical models. As such, CTE has great potential for future clinical solutions and he
AU  - Majid,QA
AU  - Fricker,ATR
AU  - Gregory,DA
AU  - Davidenko,N
AU  - Hernandez,Cruz O
AU  - Jabbour,RJ
AU  - Owen,TJ
AU  - Basnett,P
AU  - Lukasiewicz,B
AU  - Stevens,M
AU  - Best,S
AU  - Cameron,R
AU  - Sinha,S
AU  - Harding,SE
AU  - Roy,I
DO  - 10.3389/fcvm.2020.554597
EP  - 32
PY  - 2020///
SN  - 2297-055X
SP  - 1
TI  - Natural biomaterials for cardiac tissue engineering: a highly biocompatible solution.
T2  - Frontiers in Cardiovascular Medicine
UR  - http://dx.doi.org/10.3389/fcvm.2020.554597
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33195451
UR  - https://www.frontiersin.org/articles/10.3389/fcvm.2020.554597/full
UR  - http://hdl.handle.net/10044/1/84034
VL  - 7
ER  -
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