Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chung:2021:10.1002/adhm.202100117,
author = {Chung, JJ and Yoo, J and Sum, BST and Li, S and Lee, S and Kim, TH and Li, Z and Stevens, MM and Georgiou, TK and Jung, Y and Jones, JR},
doi = {10.1002/adhm.202100117},
journal = {Advanced Healthcare Materials},
pages = {1--13},
title = {3D printed porous methacrylate/silica hybrid scaffold for bone substitution},
url = {http://dx.doi.org/10.1002/adhm.202100117},
volume = {10},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Inorganic–organic hybrid biomaterials made with star polymer poly(methyl methacrylate-co-3-(trimethoxysilyl)propyl methacrylate) and silica, which show promising mechanical properties, are 3D printed as bone substitutes for the first time, by direct ink writing of the sol. Three different inorganic:organic ratios of poly(methyl methacrylate-co-3-(trimethoxysilyl)propyl methacrylate)-star-SiO2 hybrid inks are printed with pore channels in the range of 100–200 µm. Mechanical properties of the 3D printed scaffolds fall within the range of trabecular bone, and MC3T3 pre-osteoblast cells are able to adhere to the scaffolds in vitro, regardless of their compositions. Osteogenic and angiogenic properties of the hybrid scaffolds are shown using a rat calvarial defect model. Hybrid scaffolds with 40:60 inorganic:organic composition are able to instigate new vascularized bone formation within its pore channels and polarize macrophages toward M2 phenotype. 3D printing inorganic–organic hybrids with sophisticated polymer structure opens up possibilities to produce novel bone graft materials.
AU  - Chung,JJ
AU  - Yoo,J
AU  - Sum,BST
AU  - Li,S
AU  - Lee,S
AU  - Kim,TH
AU  - Li,Z
AU  - Stevens,MM
AU  - Georgiou,TK
AU  - Jung,Y
AU  - Jones,JR
DO  - 10.1002/adhm.202100117
EP  - 13
PY  - 2021///
SN  - 2192-2640
SP  - 1
TI  - 3D printed porous methacrylate/silica hybrid scaffold for bone substitution
T2  - Advanced Healthcare Materials
UR  - http://dx.doi.org/10.1002/adhm.202100117
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000647193600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://onlinelibrary.wiley.com/doi/10.1002/adhm.202100117
UR  - http://hdl.handle.net/10044/1/88824
VL  - 10
ER  -
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