Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Liu:2016:10.1039/c5nr08423g,
author = {Liu, NJ and Chapman, R and Lin, Y and Mmesi, J and Bentham, A and Tyreman, M and Abraham, S and Stevens, MM},
doi = {10.1039/c5nr08423g},
journal = {Nanoscale},
pages = {4482--4485},
title = {Point of care testing of phospholipase A2 group IIA for serological diagnosis of rheumatoid arthritis.},
url = {http://dx.doi.org/10.1039/c5nr08423g},
volume = {8},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Secretory phospholipase A2 group IIA (sPLA2-IIA) was examined as a point of care marker for determining disease activity in rheumatoid (RA) and psoriatic (PsA) arthritis. Serum concentration and activity of sPLA2-IIA were measured using in-house antibodies and a novel point of care lateral flow device assay in patients diagnosed with varying severities of RA (n = 30) and PsA (n = 25) and found to correlate strongly with C-reactive protein (CRP). Levels of all markers were elevated in patients with active RA over those with inactive RA as well as both active and inactive PsA, indicating that sPLA2-IIA can be used as an analogue to CRP for RA diagnosis at point of care.
AU  - Liu,NJ
AU  - Chapman,R
AU  - Lin,Y
AU  - Mmesi,J
AU  - Bentham,A
AU  - Tyreman,M
AU  - Abraham,S
AU  - Stevens,MM
DO  - 10.1039/c5nr08423g
EP  - 4485
PY  - 2016///
SN  - 2040-3372
SP  - 4482
TI  - Point of care testing of phospholipase A2 group IIA for serological diagnosis of rheumatoid arthritis.
T2  - Nanoscale
UR  - http://dx.doi.org/10.1039/c5nr08423g
UR  - http://hdl.handle.net/10044/1/29634
VL  - 8
ER  -
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