Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mawad:2016:10.1126/sciadv.1601007,
author = {Mawad, D and Mansfield, C and Lauto, A and Perbellini, F and Nelson, G and Tonkin, J and Bello, S and Carrod, D and Micolich, A and Mahat, M and Simonotto, J and Payne, D and Lyon, A and Gooding, J and Harding, S and Terracciano, C and Stevens, MM},
doi = {10.1126/sciadv.1601007},
journal = {Science Advances},
title = {A conducting polymer with enhanced electronic stability applied in cardiac models},
url = {http://dx.doi.org/10.1126/sciadv.1601007},
volume = {2},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Electrically active constructs can have a beneficial effect on electroresponsive tissues, such as the brain, heart, and nervous system. Conducting polymers (CPs) are being considered as components of these constructs because of their intrinsic electroactive and flexible nature. However, their clinical application has been largely hampered by their short operational time due to a decrease in their electronic properties. We show that, by immobilizing the dopant in the conductive scaffold, we can prevent its electric deterioration. We grew polyaniline (PANI) doped with phytic acid on the surface of a chitosan film. The strong chelation between phytic acid and chitosan led to a conductive patch with retained electroactivity, low surface resistivity (35.85 ± 9.40 kilohms per square), and oxidized form after 2 weeks of incubation in physiological medium. Ex vivo experiments revealed that the conductive nature of the patch has an immediate effect on the electrophysiology of the heart. Preliminary in vivo experiments showed that the conductive patch does not induce proarrhythmogenic activities in the heart. Our findings set the foundation for the design of electronically stable CP-based scaffolds. This provides a robust conductive system that could be used at the interface with electroresponsive tissue to better understand the interaction and effect of these materials on the electrophysiology of these tissues.
AU  - Mawad,D
AU  - Mansfield,C
AU  - Lauto,A
AU  - Perbellini,F
AU  - Nelson,G
AU  - Tonkin,J
AU  - Bello,S
AU  - Carrod,D
AU  - Micolich,A
AU  - Mahat,M
AU  - Simonotto,J
AU  - Payne,D
AU  - Lyon,A
AU  - Gooding,J
AU  - Harding,S
AU  - Terracciano,C
AU  - Stevens,MM
DO  - 10.1126/sciadv.1601007
PY  - 2016///
SN  - 2375-2548
TI  - A conducting polymer with enhanced electronic stability applied in cardiac models
T2  - Science Advances
UR  - http://dx.doi.org/10.1126/sciadv.1601007
UR  - http://hdl.handle.net/10044/1/42311
VL  - 2
ER  -
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