Publications
95 results found
East L, Rushton S, Taylor ME, et al., 2002, Characterization of sugar binding by the mannose receptor family member, Endo180, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 277, Pages: 50469-50475, ISSN: 0021-9258
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- Citations: 66
Drickamer K, Taylor ME, 2002, Glycan arrays for functional glycomics, GENOME BIOLOGY, Vol: 3, ISSN: 1474-760X
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- Citations: 73
Reiling N, Klug K, Krallmann-Wenzel U, et al., 2001, Complex encounters at the macrophage-mycobacterium interface:: Studies on the role of the mannose receptor and CD14 in experimental infection models with <i>Mycobacterium avium</i>, IMMUNOBIOLOGY, Vol: 204, Pages: 558-571, ISSN: 0171-2985
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- Citations: 18
Napper CE, Dyson MH, Taylor ME, 2001, An extended conformation of the macrophage mannose receptor, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 276, Pages: 14759-14766, ISSN: 0021-9258
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- Citations: 51
Taylor ME, 2001, Structure and function of the macrophage mannose receptor., Results Probl Cell Differ, Vol: 33, Pages: 105-121, ISSN: 0080-1844
Feinberg H, Park-Snyder S, Kolatkar AR, et al., 2000, Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 275, Pages: 21539-21548, ISSN: 0021-9258
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- Citations: 102
Drickamer K, Taylor ME, Wallis R, 2000, Sugar binding in innate immunity, Wellcome Trust Review, Vol: 9, Pages: 38-40
Simpson DZ, Hitchen PG, Elmhirst EL, et al., 1999, Multiple interactions between pituitary hormones and the mannose receptor, BIOCHEMICAL JOURNAL, Vol: 343, Pages: 403-411, ISSN: 0264-6021
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- Citations: 38
Drickamer K, Taylor ME, 1998, Evolving views of protein glycosylation, TRENDS IN BIOCHEMICAL SCIENCES, Vol: 23, Pages: 321-324, ISSN: 0968-0004
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- Citations: 139
Hitchen PG, Mullin NP, Taylor ME, 1998, Orientation of sugars bound to the principal C-type carbohydrate-recognition domain of the macrophage mannose receptor, BIOCHEMICAL JOURNAL, Vol: 333, Pages: 601-608, ISSN: 0264-6021
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- Citations: 23
Weis WI, Taylor ME, Drickamer K, 1998, The C-type lectin superfamily in the immune system, IMMUNOLOGICAL REVIEWS, Vol: 163, Pages: 19-34, ISSN: 0105-2896
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- Citations: 860
Taylor ME, 1997, Evolution of a family of receptors containing multiple C-type carbohydrate-recognition domains, GLYCOBIOLOGY, Vol: 7, Pages: R5-R8, ISSN: 0959-6658
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- Citations: 34
Mullin NP, Hitchen PG, Taylor ME, 1997, Mechanism of Ca2+ and monosaccharide binding to a C-type carbohydrate-recognition domain of the macrophage mannose receptor, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 272, Pages: 5668-5681, ISSN: 0021-9258
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- Citations: 82
MULLIN NP, HALL KT, TAYLOR ME, 1994, CHARACTERIZATION OF LIGAND-BINDING TO A CARBOHYDRATE-RECOGNITION DOMAIN OF THE MACROPHAGE MANNOSE RECEPTOR, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 269, Pages: 28405-28413, ISSN: 0021-9258
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- Citations: 55
TAYLOR ME, 1993, RECOGNITION OF COMPLEX CARBOHYDRATES BY THE MACROPHAGE MANNOSE RECEPTOR, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 21, Pages: 468-473, ISSN: 0300-5127
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- Citations: 35
TAYLOR ME, DRICKAMER K, 1993, STRUCTURAL REQUIREMENTS FOR HIGH-AFFINITY BINDING OF COMPLEX LIGANDS BY THE MACROPHAGE MANNOSE RECEPTOR, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 268, Pages: 399-404
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- Citations: 205
DRICKAMER K, TAYLOR ME, 1993, BIOLOGY OF ANIMAL LECTINS, ANNUAL REVIEW OF CELL BIOLOGY, Vol: 9, Pages: 237-264, ISSN: 0743-4634
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- Citations: 708
Taylor ME, 1993, Carbohydrate-recognition proteins of macrophages and related cells, Blood Cell Biochemistry volume 5, Pages: 347-370
TAYLOR ME, DRICKAMER K, 1992, EXPRESSION AND PURIFICATION OF THE CYTOPLASMIC TAIL OF AN ENDOCYTIC RECEPTOR BY FUSION TO A CARBOHYDRATE-RECOGNITION DOMAIN, PROTEIN EXPRESSION AND PURIFICATION, Vol: 3, Pages: 308-312, ISSN: 1046-5928
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- Citations: 6
TAYLOR ME, BEZOUSKA K, DRICKAMER K, 1992, CONTRIBUTION TO LIGAND-BINDING BY MULTIPLE CARBOHYDRATE-RECOGNITION DOMAINS IN THE MACROPHAGE MANNOSE RECEPTOR, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 267, Pages: 1719-1726
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- Citations: 284
WEIS WI, QUESENBERRY MS, TAYLOR ME, et al., 1992, MOLECULAR MECHANISMS OF COMPLEX CARBOHYDRATE-RECOGNITION AT THE CELL-SURFACE, COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, Vol: 57, Pages: 281-289, ISSN: 0091-7451
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- Citations: 14
BEZOUSKA K, CRICHLOW GV, ROSE JM, et al., 1991, EVOLUTIONARY CONSERVATION OF INTRON POSITION IN A SUBFAMILY OF GENES ENCODING CARBOHYDRATE-RECOGNITION DOMAINS, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 266, Pages: 11604-11609
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- Citations: 96
TAYLOR ME, DRICKAMER K, 1991, CARBOHYDRATE-RECOGNITION DOMAINS AS TOOLS FOR RAPID PURIFICATION OF RECOMBINANT EUKARYOTIC PROTEINS, BIOCHEMICAL JOURNAL, Vol: 274, Pages: 575-580, ISSN: 0264-6021
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- Citations: 16
TAYLOR ME, CONARY JT, LENNARTZ MR, et al., 1990, PRIMARY STRUCTURE OF THE MANNOSE RECEPTOR CONTAINS MULTIPLE MOTIFS RESEMBLING CARBOHYDRATE-RECOGNITION DOMAINS, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 265, Pages: 12156-12162
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- Citations: 346
SANO A, TAYLOR ME, LEANING MS, et al., 1990, UPTAKE OF PROCESSING OF GLYCOPROTEINS BY ISOLATED RAT HEPATIC ENDOTHELIAL AND KUPFFER CELLS, JOURNAL OF HEPATOLOGY, Vol: 10, Pages: 211-216, ISSN: 0168-8278
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- Citations: 10
TAYLOR ME, BRICKELL PM, CRAIG RK, et al., 1989, STRUCTURE AND EVOLUTIONARY ORIGIN OF THE GENE ENCODING A HUMAN-SERUM MANNOSE-BINDING PROTEIN, BIOCHEMICAL JOURNAL, Vol: 262, Pages: 763-771, ISSN: 0264-6021
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- Citations: 186
GARCON N, GREGORIADIS G, TAYLOR M, et al., 1988, MANNOSE-MEDIATED TARGETED IMMUNOADJUVANT ACTION OF LIPOSOMES, IMMUNOLOGY, Vol: 64, Pages: 743-745, ISSN: 0019-2805
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- Citations: 72
TAYLOR ME, SUMMERFIELD JA, 1987, CARBOHYDRATE-BINDING PROTEINS OF HUMAN-SERUM - ISOLATION OF 2 MANNOSE FUCOSE-SPECIFIC LECTINS, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 915, Pages: 60-67, ISSN: 0006-3002
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- Citations: 35
TAYLOR ME, LEANING MS, SUMMERFIELD JA, 1987, UPTAKE AND PROCESSING OF GLYCOPROTEINS BY RAT HEPATIC MANNOSE RECEPTOR, AMERICAN JOURNAL OF PHYSIOLOGY, Vol: 252, Pages: E690-E698, ISSN: 0002-9513
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- Citations: 18
Taylor ME, Leaning MS, Summerfield JA, 1987, Uptake and processing of glycoproteins by rat hepatic mannose receptor, American Journal of Physiology - Endocrinology and Metabolism, Vol: 252, ISSN: 0193-1849
A linear compartmental model has been developed for the in vivo metabolism of glycoproteins. The model is applied to the interpretation of dynamic data from the rat on agalactoorosomucoid (AGOR), an N-acetylglucosamine (GlcNAc)-terminated glycoprotein, and three neoglycoproteins terminating in mannose [mannose36-bovine serum albumin (Man-BSA)] or glucose [maltose29-BSA (Mal29-BSA) and maltose8-BSA (Mal8-BSA)]. All of these proteins are taken up by the Man/GlcNAc receptor on hepatic sinusoidal cells. The rate of uptake was found to be determined by sugar type (Man-BSA, 0.78 min-1 > Mal29-BSA, 0.13 min-1), sugar density (Mal29-BSA > Mal8-BSA), and the geometry of the sugar display (AGOR, 0.51 min-1 > Mal29-BSA). Intracellular transport from the cell membrane to the lysosomes was slower for Man-BSA (~3 min) than for the other ligands (~0 min), suggesting that receptor-ligand uncoupling was slower for Man-BSA for which the receptor had the highest affinity or that extralysosomal catabolism of the other ligands occurred. Catabolism was also determined by the carbohydrate moiety of the ligand; it was greater for Mal29-BSA and Mal8-BSA (≥0.8 min-1) than for Man-BSA (0.27 min-1), and AGOR, with a complex oligosaccharide, was most resistant to degradation (0.14 min-1). An understanding of these structural features of glycoproteins that influence hepatic uptake, transport, and catabolism will be of value in drug targeting and for enzyme replacement in lysosomal storage disorders. Special emphasis is placed on model identifiability before experimentation as an aid in experiment design.
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