Summary
Mark Thursz is professor of hepatology at Imperial College and consultant in hepatology at St Mary's Hospital, London. His clinical interests are in viral hepatitis, alcoholic liver disease and fatty liver disease. He is currently interested in developing programmes for treatment of chronic hepatitis B infection in resource poor settings to reduce the risk of hepatocellular carcinoma.
Professor Thursz' research interests are focussed on the natural history of viral hepatitis and fatty liver disease and the factors which determine chronic infection and progressive liver disease. He has a special interest in the genetic determinants of disease outcomes using genetic association and genome wide scanning to identify causative variants.
Professor Thursz is chief investigator on two multi-centre trials: The warfarin anticoagulation for liver fibrosis in patients transplanted for hepatitis C (WAFT-C) trial and the steroids or pentoxifylline for alcoholic hepatitis (STOPAH) trial.
Professor Thursz is a former secretary of the British Association for Study of the Liver (BASL) and is currently vice-secretary of the European Association for Study of the Liver. In this role he has special responsibility for EU policy and advocacy in Brussels.
Publications
Journals
Thursz M, Mathurin P, 2024, Targeting IL-1 in severe alcohol-related hepatitis: How many frogs will we need to kiss to find an effective therapy?, J Hepatol
Forlano R, Martinez-Gili L, Takis P, et al., 2024, Disruption of gut barrier integrity and host-microbiome interactions underlie MASLD severity in patients with type-2 diabetes mellitus, Gut Microbes, Vol:16, ISSN:1949-0976
Nguyen LBL, Lemoine M, Ndow G, et al., 2024, Treat All versus targeted strategies to select HBV-infected people for antiviral therapy in The Gambia, west Africa: a cost-effectiveness analysis., Lancet Glob Health, Vol:12, Pages:e66-e78
Tyson LD, Atkinson S, Hunter RW, et al., 2024, Editorial: Unmasking the silent threat-acute kidney injury in alcohol-associated hepatitis. Authors' reply., Aliment Pharmacol Ther, Vol:59, Pages:124-125
Thursz M, Lingford-Hughes A, 2023, Advances in the understanding and management of alcohol-related liver disease., Bmj, Vol:383