Imperial College London

ProfessorMarkThursz

Faculty of MedicineDepartment of Surgery & Cancer

Professor of Hepatology
 
 
 
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Contact

 

+44 (0)20 3312 1903m.thursz

 
 
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Assistant

 

Ms Dawn Campbell +44 (0)20 3312 6454

 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

375 results found

Atkinson S, Spivak I, Cabezas J, Bataller R, Trautwein C, Thursz MR, Strnad Pet al., 2017, Low serum transferrin indicates short-term mortality in severe alcoholic hepatitis, International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S117-S117, ISSN: 0168-8278

CONFERENCE PAPER

Atkinson SR, Maurice J, Vergis N, Forrest E, Thursz MRet al., 2017, Serum procalcitonin correlates with baseline renal function and predicts mortality in severe alcoholic hepatitis, International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S117-S117, ISSN: 0168-8278

CONFERENCE PAPER

Atkinson SR, Vergis N, Louvet A, Thursz MRet al., 2017, Universal screening of acute medical admissions for excess alcohol consumption: What's the misuse?, JOURNAL OF HEPATOLOGY, Vol: 67, Pages: 448-450, ISSN: 0168-8278

JOURNAL ARTICLE

Atkinson SR, Way MJ, McQuillin A, Morgan MY, Thursz MRet al., 2017, Homozygosity for rs738409:G in PNPLA3 is associated with increased mortality following an episode of severe alcoholic hepatitis, JOURNAL OF HEPATOLOGY, Vol: 67, Pages: 120-127, ISSN: 0168-8278

JOURNAL ARTICLE

Atkinson SR, Way MJ, McQuillin A, Morgan MY, Thursz MRet al., 2017, Drinking behaviour and rs738409:G in PNPLA3 are associated with slower recovery of liver function following severe alcoholic hepatitis, International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S116-S117, ISSN: 0168-8278

CONFERENCE PAPER

Bernsmeier C, Triantafyllou E, Brenig R, Lebosse FJ, Singanayagam A, Patel VC, Pop OT, Khamri W, Nathwani R, Tidswell R, Weston CJ, Adams DH, Thursz MR, Wendon JA, Antoniades CGet al., 2017, CD14+CD15-HLA-DR- myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure., Gut

OBJECTIVE: Immune paresis in patients with acute-on-chronic liver failure (ACLF) accounts for infection susceptibility and increased mortality. Immunosuppressive mononuclear CD14+HLA-DR- myeloid-derived suppressor cells (M-MDSCs) have recently been identified to quell antimicrobial responses in immune-mediated diseases. We sought to delineate the function and derivation of M-MDSC in patients with ACLF, and explore potential targets to augment antimicrobial responses. DESIGN: Patients with ACLF (n=41) were compared with healthy subjects (n=25) and patients with cirrhosis (n=22) or acute liver failure (n=30). CD14+CD15-CD11b+HLA-DR- cells were identified as per definition of M-MDSC and detailed immunophenotypic analyses were performed. Suppression of T cell activation was assessed by mixed lymphocyte reaction. Assessment of innate immune function included cytokine expression in response to Toll-like receptor (TLR-2, TLR-4 and TLR-9) stimulation and phagocytosis assays using flow cytometry and live cell imaging-based techniques. RESULTS: Circulating CD14+CD15-CD11b+HLA-DR- M-MDSCs were markedly expanded in patients with ACLF (55% of CD14+ cells). M-MDSC displayed immunosuppressive properties, significantly decreasing T cell proliferation (p=0.01), producing less tumour necrosis factor-alpha/interleukin-6 in response to TLR stimulation (all p<0.01), and reduced bacterial uptake of Escherichia coli (p<0.001). Persistently low expression of HLA-DR during disease evolution was linked to secondary infection and 28-day mortality. Recurrent TLR-2 and TLR-4 stimulation expanded M-MDSC in vitro. By contrast, TLR-3 agonism reconstituted HLA-DR expression and innate immune function ex vivo. CONCLUSION: Immunosuppressive CD14+HLA-DR- M-MDSCs are expanded in patients with ACLF. They were depicted by suppressing T cell function, attenuated antimicrobial innate immune responses, linked to secondary infection, disease severity and prognosis. TLR-3 agonism reversed M-MDSC expansi

JOURNAL ARTICLE

Dhanda A, Atkinson S, Thursz M, 2017, Variation in the use of corticosteroids for the treatment of acute severe alcoholic hepatitis in the post-STOPAH era: results of a UK national survey, International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S345-S346, ISSN: 0168-8278

CONFERENCE PAPER

Dhar A, Mullish BH, Thursz MR, 2017, Anticoagulation in chronic liver disease, JOURNAL OF HEPATOLOGY, Vol: 66, Pages: 1313-1326, ISSN: 0168-8278

JOURNAL ARTICLE

Elsharkawy A, Fouad R, El Akel W, El Raziky M, Hassany M, Shiha G, Said M, Motawea I, El Demerdash T, Seif S, Gaballah A, El Shazly Y, Makhlouf MAM, Waked I, Abdelaziz AO, Yosry A, El Serafy M, Thursz M, Doss W, Esmat Get al., 2017, Sofosbuvir-based treatment regimens: real life results of 14 409 chronic HCV genotype 4 patients in Egypt, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 45, Pages: 681-687, ISSN: 0269-2813

JOURNAL ARTICLE

Forlano R, Manousou P, Mullish B, Olaoke A, Khelifa MZ, Giannakeas N, Tzallas A, Tsipouras MG, Yee M, Taylor-Robinson SD, Lloyd J, Goldin RD, Thursz MR, Khan SAet al., 2017, Assessment of non invasive markers of fibrosis against collagen quantitation and NASH-CRN scoring in liver biopsies of NAFLD patients, 68th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Publisher: WILEY, Pages: 334A-334A, ISSN: 0270-9139

CONFERENCE PAPER

Forlano R, Maurice J, Angkathunyakul N, Goldin E, Yee M, Serviddio G, Giannakeas N, Tzallas AT, Tsipouras MG, Goldin RD, Thursz M, Manousou Pet al., 2017, Development and validation of an automated system for assessment of liver steatosis and fibrosis in routine histological images in patients with Non-Alcoholic Fatty Liver Disease, International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S589-S590, ISSN: 0168-8278

CONFERENCE PAPER

Forlano R, Maurice J, Mullish BH, Angkathunyakul N, Goldin E, Serviddio G, Yee M, Giannakeas N, Tzallas AT, Tsipouras MG, Khan S, Taylor-Robinson S, Goldin RD, Thursz M, Manousou Pet al., 2017, The severity of steatosis does not influence liver stiffness measurements in patients with Non-Alcoholic Fatty Liver Disease, International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S586-S587, ISSN: 0168-8278

CONFERENCE PAPER

Forlano R, Mullish BH, Angkathunyakul N, Goldin E, Yee M, Serviddio G, Giannakeas N, Tzallas AT, Tsipouras MG, Rui F, Khan S, Taylor-Robinson S, Goldin RD, Thursz MR, Manosou Pet al., 2017, PWE-094 The severity of steatosis does not influence liver stiffness measurements in patients with non-alcoholic fatty liver disease, British Society of Gastroenterology Annual Meeting, Publisher: BMJ Publishing Group, Pages: A174-A174, ISSN: 1468-3288

CONFERENCE PAPER

Forlano R, Mullish BH, Maurice J, Angkathunyakul N, Goldin E, Yee M, Serviddio G, Giannakeas N, Tzallas AT, Rui F, Goldin R, Thursz M, Manousou Pet al., 2017, PWE-093 Development and validation of an automated system for assessment of liver steatosis and fibrosis in routine: histological images in patients with non-alcoholic fatty liver disease, British Society of Gastroenterology Annual Meeting, Publisher: BMJ Publishing Group, Pages: A173-A174, ISSN: 1468-3288

CONFERENCE PAPER

Forrest E, Storey N, Rohit S, Shawcross D, McCune A, Gleeson D, Hood S, Wright M, Dillon J, Fraser A, Patch D, Richardson P, Masson S, Austin A, Ryan J, Atkinson S, Ryder S, Thursz M, Allison M, Hayes Pet al., 2017, Baseline neutrophil to lymphocyte ratio can identify favourable corticosteroid response in alcoholic hepatitis, International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S99-S99, ISSN: 0168-8278

CONFERENCE PAPER

Howell J, Atkinson S, PInato DJ, Knapp S, Ward C, Minisini R, Burlone M, Leutner M, Pirisi M, Khan S, Odenthal M, Thursz M, Sharma Ret al., 2017, Identification of actionable mutations in circulating cell-free tumour DNA as a prognostic biomarker in hepatocellular carcinoma, International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S449-S449, ISSN: 0168-8278

CONFERENCE PAPER

Howell JA, Khan SA, Knapp S, Thursz MR, Sharma Ret al., 2017, The clinical role of circulating free tumor DNA in gastrointestinal malignancy, TRANSLATIONAL RESEARCH, Vol: 183, Pages: 137-154, ISSN: 1931-5244

JOURNAL ARTICLE

Khamri W, Abeles RD, Hou TZ, Anderson AE, El-Masry A, Triantafyllou E, Bernsmeier C, Larsen FS, Singanayagam A, Kudo N, Possamai LA, Lebosse F, Auzinger G, Bernal W, Willars C, Weston CJ, Lombardi G, Wendon J, Thursz M, Antoniades CGet al., 2017, Increased Expression of Cytotoxic T-Lymphocyte-Associated Protein 4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure, GASTROENTEROLOGY, Vol: 153, Pages: 263-+, ISSN: 0016-5085

JOURNAL ARTICLE

Kumar A, Gangadharan B, Cobbold J, Thursz M, Zitzmann Net al., 2017, Absolute quantitation of disease protein biomarkers in a single LC-MS acquisition using apolipoprotein F as an example, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322

JOURNAL ARTICLE

Lazarus JV, Wiktor S, Colombo M, Thursz Met al., 2017, Micro-elimination - A path to global elimination of hepatitis C, JOURNAL OF HEPATOLOGY, Vol: 67, Pages: 665-666, ISSN: 0168-8278

JOURNAL ARTICLE

Lebosse F, Kumar N, Pop O, Nathwani R, Singanayagam A, Mukherjee S, Hou TZ, Quaglia A, Zoulim F, Wendon J, Thursz M, Dhar A, Khamri W, Antoniades CGet al., 2017, A novel population of immunosuppressive CD8 T cells is expanded in patients with decompensated liver disease, International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S146-S146, ISSN: 0168-8278

CONFERENCE PAPER

Lemoine M, Thursz M, Mallet V, Shimakawa Yet al., 2017, Diagnostic accuracy of the gamma-glutamyl transpeptidase to platelet ratio (GPR) using transient elastography as a reference, GUT, Vol: 66, Pages: 195-+, ISSN: 0017-5749

JOURNAL ARTICLE

Lemoine M, Thursz MR, 2017, Battlefield against hepatitis B infection and HCC in Africa, JOURNAL OF HEPATOLOGY, Vol: 66, Pages: 645-654, ISSN: 0168-8278

JOURNAL ARTICLE

Maurice J, Judge R, Baldry M, Hubbard J, Cooke G, Lemoine M, Thursz M, Nelson M, Garvey Let al., 2017, NAFLD in HIV is associated with age and metabolic factors but not HIV-specific parameters in a prospectively characterised cohort, Publisher: WILEY, Pages: 41-42, ISSN: 1464-2662

CONFERENCE PAPER

Maurice JB, Patel A, Scott AJ, Patel K, Thursz M, Lemoine Met al., 2017, Prevalence and risk factors of nonalcoholic fatty liver disease in HIV-monoinfection, AIDS, Vol: 31, Pages: 1621-1632, ISSN: 0269-9370

JOURNAL ARTICLE

McEwan P, Selvapatt N, Brown A, Thursz M, Bennett H, Webster S, Kalsekar A, Yuan Y, Brenner M, Gordon Jet al., 2017, A clinician's guide to the cost and health benefits of hepatitis C cure assessed from the individual patient perspective, EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, Vol: 29, Pages: 208-214, ISSN: 0954-691X

JOURNAL ARTICLE

Mohamed Z, Mbwambo J, Rwegasha J, Shimakawa Y, Bhagani S, Chevaliez S, Makani J, Taylor-Robinson S, Thursz M, Lemoine Met al., 2017, High prevalence of chronic hepatitis C in injecting drug users in Tanzania, East Africa: a neglected burden of disease, International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S416-S416, ISSN: 0168-8278

CONFERENCE PAPER

Mohamed Z, Mbwambo J, Shimakawa Y, Poiteau L, Chevaliez S, Pawlotsky J-M, Rwegasha J, Bhagani S, Taylor-Robinson SD, Makani J, Thursz MR, Lemoine Met al., 2017, Clinical utility of HCV core antigen detection and quantification using serum samples and dried blood spots in people who inject drugs in Dar-es-Salaam, Tanzania, JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, Vol: 20, ISSN: 1758-2652

JOURNAL ARTICLE

Mukherjee S, Pop O, Triantafyllou E, Khamri W, Curbishley S, Thursz M, Adams D, Antoniades Cet al., 2017, Role of expression of the tumour-associated macrophage receptor, MERTK, in hepatocellular carcinoma, Spring Meeting on Clinician Scientists in Training, Publisher: ELSEVIER SCIENCE INC, Pages: 72-72, ISSN: 0140-6736

CONFERENCE PAPER

Mullish B, Forlano R, Yee M, Giannakeas N, Goldin RD, Taylor-Robinson SD, Khan SA, Thursz MR, Manousou Pet al., 2017, Development of an algorithm for the prediction of cardiovascular events in patients with NAFLD: the role of mean platelet volume, 68th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Publisher: WILEY, Pages: 1175A-1176A, ISSN: 0270-9139

CONFERENCE PAPER

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