Imperial College London

ProfessorMarkThursz

Faculty of MedicineDepartment of Surgery & Cancer

Professor of Hepatology
 
 
 
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Contact

 

+44 (0)20 3312 1903m.thursz

 
 
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Assistant

 

Ms Dawn Campbell +44 (0)20 3312 6454

 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

395 results found

Atkinson SR, McQuillin A, Morgan MY, Thursz MRet al., 2018, People who survive an episode of severe alcoholic hepatitis should be advised to maintain total abstinence from alcohol., Hepatology, Vol: 67, Pages: 2479-2480

JOURNAL ARTICLE

Atkinson SR, Way MJ, McQuillin A, Morgan MY, Thursz MRet al., 2018, Reply to: "The PNPLA3 SNP rs738409:G allele is associated with increased liver disease-associated mortality but reduced overall mortality in a population-based cohort'', JOURNAL OF HEPATOLOGY, Vol: 68, Pages: 860-862, ISSN: 0168-8278

JOURNAL ARTICLE

Bernsmeier C, Triantafyllou E, Brenig R, Lebosse FJ, Singanayagam A, Patel VC, Pop OT, Khamri W, Nathwani R, Tidswell R, Weston CJ, Adams DH, Thursz MR, Wendon JA, Antoniades CGet al., 2018, CD14(+) CD15(-) HLA-DR- myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure, GUT, Vol: 67, Pages: 1155-1167, ISSN: 0017-5749

JOURNAL ARTICLE

Cobbold JFL, Atkinson S, Marchesi JR, Smith A, Wai SN, Stove J, Shojaee-Moradie F, Jackson N, Umpleby AM, Fitzpatrick J, Thomas EL, Bell JD, Holmes E, Taylor-Robinson SD, Goldin RD, Yee MS, Anstee QM, Thursz MRet al., 2018, Rifaximin in non-alcoholic steatohepatitis: An open-label pilot study, International Liver Congress / 48th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: WILEY, Pages: 69-77, ISSN: 1386-6346

CONFERENCE PAPER

Forlano R, Mullish BH, Katertsidis N, Giannakeas N, Tzallas A, Tsipouras M, Yee M, Taylor-Robinson S, Thursz M, Manousou Pet al., 2018, SAT-476 A mobile application for the management and follow-up of patients with Non-Alcoholic Fatty Liver Disease, International Liver Congress 2018, Paris, France

POSTER

Forlano R, Mullish BH, Katertsidis N, Giannakeas N, Tzallas A, Tsipouras M, Yee M, Taylor-Robinson S, Thursz M, Manousou Pet al., 2018, SAT-476 A mobile application for the management and follow-up ofpatients with Non-Alcoholic Fatty Liver Disease, International Liver Congress 2018, Publisher: Elsevier, Pages: S819-S819, ISSN: 0168-8278

CONFERENCE PAPER

Forrest EH, Atkinson SR, Richardson P, Masson S, Ryder S, Thursz MR, Allison Met al., 2018, Application of prognostic scores in the STOPAH trial: Discriminant function is no longer the optimal scoring system in alcoholic hepatitis, JOURNAL OF HEPATOLOGY, Vol: 68, Pages: 511-518, ISSN: 0168-8278

JOURNAL ARTICLE

Forrest EH, Atkinson SR, Richardson P, Masson S, Ryder S, Thursz MR, Allison Met al., 2018, Reply to: "The long-term prognosis of alcoholic hepatitis is poor and independent of disease severity for patients surviving an acute episode'', JOURNAL OF HEPATOLOGY, Vol: 68, Pages: 1332-1332, ISSN: 0168-8278

JOURNAL ARTICLE

Louvet A, Thursz MR, Kim DJ, Labreuche J, Atkinson S, Sidhu SS, O'Grady JG, Akriviadis E, Sinakos E, Carithers RL, Ramond M-J, Maddrey WC, Morgan TR, Duhamel A, Mathurin Pet al., 2018, Corticosteroids Reduce Risk of Death Within 28 Days for Patients With Severe Alcoholic Hepatitis, Compared With Pentoxifylline or Placebo-a Meta-analysis of Individual Data., Gastroenterology

BACKGROUND & AIMS: We performed a meta-analysis of individual patient data from 11 randomized controlled trials comparing corticosteroids, pentoxifylline, or their combination in patients with severe alcoholic hepatitis. We compared the effects of the treatments on survival for 28 days or 6 months, and response to treatment based on the Lille model. METHODS: We searched PubMed for randomized controlled trials of pharmacologic therapy for severe alcoholic hepatitis. Our final analysis comprised 11 studies, of 2111 patients. We performed four meta-analyses of the effects of corticosteroids vs. placebo or control, corticosteroids vs. pentoxifylline, corticosteroids and pentoxifylline vs. corticosteroids and placebo or control, and pentoxifylline vs. placebo. In each meta-analysis, the effect of treatment on the primary outcome (overall survival at 28 days, defined as the period from the first day of assigned treatment to 28 days) was estimated using a Cox proportional hazards regression model, stratified by trial. RESULTS: Corticosteroid treatment significantly decreased risk of death within 28 days compared to controls (hazard ratio [HR], 0.64; 95% CI, 0.48-0.86) or to pentoxifylline (HR, 0.64; 95% CI, 0.43-0.95). In multiple imputation and complete case analyses, the effect of corticosteroids compared to controls remained significant. When we compared corticosteroids vs. pentoxifylline, the corticosteroid effect remained significant in the complete case analysis (HR, 0.66; P=.04) but not in multiple-imputation analysis (HR, 0.71; P=.08). There was no difference in 28-day mortality when patients were given a combination of corticosteroids and pentoxifylline vs. corticosteroids alone or between patients given pentoxifylline vs. control. In our analysis of secondary outcomes, we found no significant differences in 6-month mortality when any treatments or controls were compared. Corticosteroids were significantly associated with increased response to therapy compared

JOURNAL ARTICLE

Ortega-Prieto AM, Skelton JK, Wai SN, Large E, Lussignol M, Vizcay-Barrena G, Hughes D, Fleck RA, Thursz M, Catanese MT, Dorner Met al., 2018, 3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection, NATURE COMMUNICATIONS, Vol: 9, ISSN: 2041-1723

JOURNAL ARTICLE

Triantafyllou E, Pop OT, Possamai LA, Wilhelm A, Liaskou E, Singanayagam A, Bernsmeier C, Khamri W, Petts G, Dargue R, Davies SP, Tickle J, Yuksel M, Patel VC, Abeles RD, Stamataki Z, Curbishley SM, Ma Y, Wilson ID, Coen M, Woollard KJ, Quaglia A, Wendon J, Thursz MR, Adams DH, Weston CJ, Antoniades CGet al., 2018, MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure, GUT, Vol: 67, Pages: 333-347, ISSN: 0017-5749

JOURNAL ARTICLE

Atkinson S, Spivak I, Cabezas J, Bataller R, Trautwein C, Thursz MR, Strnad Pet al., 2017, Low serum transferrin indicates short-term mortality in severe alcoholic hepatitis, International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S117-S117, ISSN: 0168-8278

CONFERENCE PAPER

Atkinson SR, Forlano R, Manousou P, Grove J, Aithal G, McQuillin A, Quaglia A, Thursz MR, Goldin R, Morgan MYet al., 2017, CARRIAGE OF RS738409 IN PNPLA3 IS POSITIVELY ASSOCIATED WITH THE SEVERITY OF HISTOLOGICAL DAMAGE IN PATIENTS WITH ALCOHOLIC HEPATITIS, Publisher: OXFORD UNIV PRESS, ISSN: 0735-0414

CONFERENCE PAPER

Atkinson SR, Maurice J, Vergis N, Forrest E, Thursz MRet al., 2017, Serum procalcitonin correlates with baseline renal function and predicts mortality in severe alcoholic hepatitis, International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S117-S117, ISSN: 0168-8278

CONFERENCE PAPER

Atkinson SR, Vergis N, Louvet A, Thursz MRet al., 2017, Universal screening of acute medical admissions for excess alcohol consumption: What's the misuse?, JOURNAL OF HEPATOLOGY, Vol: 67, Pages: 448-450, ISSN: 0168-8278

JOURNAL ARTICLE

Atkinson SR, Way MJ, McQuillin A, Morgan MY, Thursz MRet al., 2017, Homozygosity for rs738409:G in PNPLA3 is associated with increased mortality following an episode of severe alcoholic hepatitis, JOURNAL OF HEPATOLOGY, Vol: 67, Pages: 120-127, ISSN: 0168-8278

JOURNAL ARTICLE

Atkinson SR, Way MJ, McQuillin A, Morgan MY, Thursz MRet al., 2017, Drinking behaviour and rs738409:G in PNPLA3 are associated with slower recovery of liver function following severe alcoholic hepatitis, International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S116-S117, ISSN: 0168-8278

CONFERENCE PAPER

Dhanda A, Atkinson S, Thursz M, 2017, Variation in the use of corticosteroids for the treatment of acute severe alcoholic hepatitis in the post-STOPAH era: results of a UK national survey, International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S345-S346, ISSN: 0168-8278

CONFERENCE PAPER

Dhar A, Mullish BH, Thursz MR, 2017, Anticoagulation in chronic liver disease, JOURNAL OF HEPATOLOGY, Vol: 66, Pages: 1313-1326, ISSN: 0168-8278

JOURNAL ARTICLE

Elsharkawy A, Fouad R, El Akel W, El Raziky M, Hassany M, Shiha G, Said M, Motawea I, El Demerdash T, Seif S, Gaballah A, El Shazly Y, Makhlouf MAM, Waked I, Abdelaziz AO, Yosry A, El Serafy M, Thursz M, Doss W, Esmat Get al., 2017, Sofosbuvir-based treatment regimens: real life results of 14 409 chronic HCV genotype 4 patients in Egypt, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 45, Pages: 681-687, ISSN: 0269-2813

JOURNAL ARTICLE

Forlano R, Manousou P, Mullish B, Olaoke A, Khelifa MZ, Giannakeas N, Tzallas A, Tsipouras MG, Yee M, Taylor-Robinson SD, Lloyd J, Goldin RD, Thursz MR, Khan SAet al., 2017, Assessment of non invasive markers of fibrosis against collagen quantitation and NASH-CRN scoring in liver biopsies of NAFLD patients, 68th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Publisher: WILEY, Pages: 334A-334A, ISSN: 0270-9139

CONFERENCE PAPER

Forlano R, Maurice J, Angkathunyakul N, Goldin E, Yee M, Serviddio G, Giannakeas N, Tzallas AT, Tsipouras MG, Goldin RD, Thursz M, Manousou Pet al., 2017, Development and validation of an automated system for assessment of liver steatosis and fibrosis in routine histological images in patients with Non-Alcoholic Fatty Liver Disease, International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S589-S590, ISSN: 0168-8278

CONFERENCE PAPER

Forlano R, Maurice J, Mullish BH, Angkathunyakul N, Goldin E, Serviddio G, Yee M, Giannakeas N, Tzallas AT, Tsipouras MG, Khan S, Taylor-Robinson S, Goldin RD, Thursz M, Manousou Pet al., 2017, The severity of steatosis does not influence liver stiffness measurements in patients with Non-Alcoholic Fatty Liver Disease, International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S586-S587, ISSN: 0168-8278

CONFERENCE PAPER

Forlano R, Mullish BH, Angkathunyakul N, Goldin E, Yee M, Serviddio G, Giannakeas N, Tzallas AT, Tsipouras MG, Rui F, Khan S, Taylor-Robinson S, Goldin RD, Thursz M, Manousou Pet al., 2017, THE SEVERITY OF STEATOSIS DOES NOT INFLUENCE LIVER STIFFNESS MEASUREMENTS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE, Annual General Meeting of the British-Society-of-Gastroenterology (BSG), Publisher: BMJ PUBLISHING GROUP, Pages: A174-A174, ISSN: 0017-5749

CONFERENCE PAPER

Forlano R, Mullish BH, Maurice J, Angkathunyakul N, Goldin E, Yee M, Serviddio G, Giannakeas N, Tzallas AT, Tsipouras MG, Rui F, Goldin RD, Thursz M, Manousou Pet al., 2017, DEVELOPMENTAND VALIDATION OF AN AUTOMATED SYSTEM FOR ASSESSMENT OF LIVER STEATOSIS AND FIBROSIS IN ROUTINE: HISTOLOGICAL IMAGES IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE, Annual General Meeting of the British-Society-of-Gastroenterology (BSG), Publisher: BMJ PUBLISHING GROUP, Pages: A173-A174, ISSN: 0017-5749

CONFERENCE PAPER

Forrest E, Storey N, Rohit S, Shawcross D, McCune A, Gleeson D, Hood S, Wright M, Dillon J, Fraser A, Patch D, Richardson P, Masson S, Austin A, Ryan J, Atkinson S, Ryder S, Thursz M, Allison M, Hayes Pet al., 2017, Baseline neutrophil to lymphocyte ratio can identify favourable corticosteroid response in alcoholic hepatitis, International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S99-S99, ISSN: 0168-8278

CONFERENCE PAPER

Hamesch K, Atkinson SR, Spivak I, Gueldiken N, Cabezas J, Argemi J, Bataller R, Trautwein C, Thursz MR, Strnad Pet al., 2017, Transferrin Is Downregulated in Alcoholic Hepatitis and Predicts Short-term Survival, 68th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Publisher: WILEY, Pages: 63A-64A, ISSN: 0270-9139

CONFERENCE PAPER

Howell J, Atkinson S, PInato DJ, Knapp S, Ward C, Minisini R, Burlone M, Leutner M, Pirisi M, Khan S, Odenthal M, Thursz M, Sharma Ret al., 2017, Identification of actionable mutations in circulating cell-free tumour DNA as a prognostic biomarker in hepatocellular carcinoma, International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S449-S449, ISSN: 0168-8278

CONFERENCE PAPER

Howell JA, Khan SA, Knapp S, Thursz MR, Sharma Ret al., 2017, The clinical role of circulating free tumor DNA in gastrointestinal malignancy, TRANSLATIONAL RESEARCH, Vol: 183, Pages: 137-154, ISSN: 1931-5244

JOURNAL ARTICLE

Khamri W, Abeles RD, Hou TZ, Anderson AE, El-Masry A, Triantafyllou E, Bernsmeier C, Larsen FS, Singanayagam A, Kudo N, Possamai LA, Lebosse F, Auzinger G, Bernal W, Willars C, Weston CJ, Lombardi G, Wendon J, Thursz M, Antoniades CGet al., 2017, Increased Expression of Cytotoxic T-Lymphocyte-Associated Protein 4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure, GASTROENTEROLOGY, Vol: 153, Pages: 263-+, ISSN: 0016-5085

JOURNAL ARTICLE

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