Imperial College London
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Professor Mireille B Toledano

Faculty of Medicine, School of Public Health

Mohn Chair; Population Child Health & Director-Mohn Centre
 
 
 
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Contact

 

m.toledano Website

 
 
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Location

 

525Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kogevinas:2016:10.1097/EDE.0000000000000544,
author = {Kogevinas, M and Bustamante, M and Gracia-Lavedán, E and Ballester, F and Cordier, S and Costet, N and Espinosa, A and Grazuleviciene, R and Danileviciute, A and Ibarluzea, J and Karadanelli, M and Krasner, S and Patelarou, E and Stephanou, E and Tardón, A and Toledano, MB and Wright, J and Villanueva, CM and Nieuwenhuijsen, M},
doi = {10.1097/EDE.0000000000000544},
journal = {Epidemiology},
pages = {903--911},
title = {Drinking water disinfection byproducts, genetic polymorphisms, and birth outcomes in a European mother-child cohort study},
url = {http://dx.doi.org/10.1097/EDE.0000000000000544},
volume = {27},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: We examined the association between exposure during pregnancy to trihalomethanes, the most common water disinfection by-products, and birth outcomes in a European cohort study (HiWate). We took into account exposure through different water uses, measures of water toxicity, and genetic susceptibility. METHODS: We enrolled 14,005 mothers (2002-2010) and their children from France, Greece, Lithuania, Spain, and the UK. Information on lifestyle- and water-related activities were recorded. We ascertained residential concentrations of trihalomethanes through regulatory records and ad hoc sampling campaigns and estimated route-specific trihalomethane uptake by trimester and for whole pregnancy. We examined single nucleotide polymorphisms and copy number variants in disinfection by-product metabolizing genes in nested case-control studies. RESULTS: Average levels of trihalomethanes ranged from around 10μg/L to above the regulatory limits in the EU of 100 μg/L between centers. There was no association between birth weight and total trihalomethane exposure during pregnancy (beta= 2.2 g in birth weight per 10μg/L of THM, 95%CI -3.3, 7.6). Birthweight was not associated with exposure through different routes or with specific trihalomethane species. Exposure to trihalomethanes was not associated with low birth weight (OR per 10μg/L=1.02, 95%CI 0.95, 1.10), small-for-gestational age (OR=0.99, 0.94, 1.03) and preterm births (OR= 0.98, 0.9, 1.05). We found no gene-environment interactions for mother or child polymorphisms in relation to preterm birth or small-for-gestational age. CONCLUSIONS: In this large European study we found no association between birth outcomes and trihalomethane exposures during pregnancy in the total population or in potentially genetically susceptible subgroups.
AU  - Kogevinas,M
AU  - Bustamante,M
AU  - Gracia-Lavedán,E
AU  - Ballester,F
AU  - Cordier,S
AU  - Costet,N
AU  - Espinosa,A
AU  - Grazuleviciene,R
AU  - Danileviciute,A
AU  - Ibarluzea,J
AU  - Karadanelli,M
AU  - Krasner,S
AU  - Patelarou,E
AU  - Stephanou,E
AU  - Tardón,A
AU  - Toledano,MB
AU  - Wright,J
AU  - Villanueva,CM
AU  - Nieuwenhuijsen,M
DO  - 10.1097/EDE.0000000000000544
EP  - 911
PY  - 2016///
SN  - 1044-3983
SP  - 903
TI  - Drinking water disinfection byproducts, genetic polymorphisms, and birth outcomes in a European mother-child cohort study
T2  - Epidemiology
UR  - http://dx.doi.org/10.1097/EDE.0000000000000544
UR  - http://hdl.handle.net/10044/1/39456
VL  - 27
ER  -
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