Imperial College London

Professor Martin Wilkins

Faculty of MedicineDepartment of Medicine

Head of the Department of Medicine
 
 
 
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Contact

 

+44 (0)20 3313 2049m.wilkins

 
 
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Location

 

NIHR / Wellcome Trust Clinical Research FacilityICTEM buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

180 results found

Grieve AP, Chow S-C, Curram J, Dawe S, Harnisch LO, Henig NR, Hung HMJ, Ivy DD, Kawut SM, Rahbar MH, Xiao S, Wilkins MRet al., 2013, Advancing clinical trial design in pulmonary hypertension, PULMONARY CIRCULATION, Vol: 3, Pages: 217-225, ISSN: 2045-8932

JOURNAL ARTICLE

Hoeper MM, Bogaard HJ, Condliffe R, Frantz R, Khanna D, Kurzyna M, Langleben D, Manes A, Satoh T, Torres F, Wilkins MR, Badesch DBet al., 2013, Definitions and Diagnosis of Pulmonary Hypertension, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 62, Pages: D42-D50, ISSN: 0735-1097

JOURNAL ARTICLE

Howard LSGE, Watson GMJ, Wharton J, Rhodes CJ, Chan K, Khengar R, Robbins PA, Kiely DG, Condliffe R, Elliott CA, Pepke-Zaba J, Sheares K, Morrell NW, Davies R, Ashby D, Gibbs JSR, Wilkins MRet al., 2013, Supplementation of iron in pulmonary hypertension: Rationale and design of a phase II clinical trial in idiopathic pulmonary arterial hypertension, PULMONARY CIRCULATION, Vol: 3, Pages: 100-107, ISSN: 2045-8932

JOURNAL ARTICLE

Rhodes CJ, Wharton J, Boon RA, Roexe T, Tsang H, Wojciak-Stothard B, Chakrabarti A, Howard LS, Gibbs JSR, Lawrie A, Condliffes R, Elliot CA, Kielys DG, Huson L, Ghofrani HA, Tiede H, Schermuly R, Zeihers AM, Dimmeler S, Wilkins MRet al., 2013, Reduced MicroRNA-150 Is Associated with Poor Survival in Pulmonary Arterial Hypertension, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, Pages: 294-302, ISSN: 1073-449X

JOURNAL ARTICLE

Rhodes CJ, Wharton J, Wilkins MR, 2013, Pulmonary hypertension: Biomarkers, Pages: 77-103, ISBN: 9783642386633

Physicians look to biomarkers to inform the management of pulmonary hypertension (PH) at all stages, from assessing susceptibility through screening, diagnosis, and risk stratification to drug selection and monitoring. PH is a heterogeneous disorder and currently there are no accepted blood biomarkers specific to any manifestation of the condition. Brain natriuretic peptide and its N-terminal peptide have been most widely studied. Other candidate prognostic biomarkers in patients with pulmonary arterial hypertension (PAH) include growth and differentiation factor-15, red cell distribution width, uric acid, creatinine, inflammatory markers such as interleukin-6, angiopoietins, and microRNAs. Combining the measurement of biomarkers reflecting different components of the pathology with other modalities may enable better molecular characterisation of PH subtypes and permit improved targeting of therapeutic strategies and disease monitoring. © Springer-Verlag Berlin Heidelberg 2013.

BOOK CHAPTER

Watson G, Oliver E, Zhao L, Wilkins MRet al., 2013, Pulmonary hypertension: Old targets revisited (Statins, PPARs, Beta-Blockers), Handbook of Experimental Pharmacology, Vol: 218, Pages: 531-548, ISSN: 0171-2004

Pulmonary arterial hypertension is a therapeutic challenge. Despite progress in recent years with three drug classes-prostanoids, endothelin receptor antagonists and phosphodiesterase type 5 inhibitors-long-term patient survival remains poor. Importantly, the introduction and commercial success of these new treatments has been accompanied by growing interest in the pathology of pulmonary hypertension. This, in turn, has stimulated a re-evaluation of the molecular factors driving the structural remodelling of pulmonary arterioles and the opportunities to preserve right ventricular function in pulmonary hypertension. Academics with restricted access to new chemicals have turned to existing drugs to investigate new ideas. It is in this context that the role of statins, peroxisome proliferator-activated receptors (PPARs) and beta-blockers are of interest as potential treatments for pulmonary hypertension. © Springer-Verlag Berlin Heidelberg 2013.

JOURNAL ARTICLE

Wilkins MR, 2013, Developing treatments for pulmonary arterial hypertension, PULMONARY CIRCULATION, Vol: 3, Pages: 156-159, ISSN: 2045-8932

JOURNAL ARTICLE

Wilkins MR, Wharton J, Gladwin MT, 2013, Update in Pulmonary Vascular Diseases 2012, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 188, Pages: 23-28, ISSN: 1073-449X

JOURNAL ARTICLE

Zhao L, Ashek A, Wang L, Fang W, Dabral S, Dubois O, Cupitt J, Pullamsetti SS, Cotroneo E, Jones H, Tomasi G, Quang-De N, Aboagye EO, El-Bahrawy MA, Barnes G, Howard LS, Gibbs JSR, Gsell W, He J-G, Wilkins MRet al., 2013, Heterogeneity in Lung (18)FDG Uptake in Pulmonary Arterial Hypertension Potential of Dynamic (18)FDG Positron Emission Tomography With Kinetic Analysis as a Bridging Biomarker for Pulmonary Vascular Remodeling Targeted Treatments, CIRCULATION, Vol: 128, Pages: 1214-1224, ISSN: 0009-7322

JOURNAL ARTICLE

Zhao L, Chen C-N, Hajji N, Oliver E, Cotroneo E, Wharton J, Wilkins MR, Wang D, Li M, Stenmark KR, McKinsey TA, Buttrick Pet al., 2013, Response to Letter Regarding Article, "Histone Deacetylation Inhibition in Pulmonary Hypertension: Therapeutic Potential of Valproic Acid and Suberoylanilide Hydroxamic Acid", CIRCULATION, Vol: 127, Pages: E540-E540, ISSN: 0009-7322

JOURNAL ARTICLE

Wojciak-Stothard B, Zhao L, Oliver E, Dubois O, Wu Y, Kardassis D, Vasilaki E, Huang M, Mitchell JA, Louise H, Prendergast GC, Wilkins MRet al., 2012, Role of RhoB in the Regulation of Pulmonary Endothelial and Smooth Muscle Cell Responses to Hypoxia, CIRCULATION RESEARCH, Vol: 110, Pages: 1423-+, ISSN: 0009-7330

JOURNAL ARTICLE

Zeng W-J, Xiong C-M, Zhao L, Shan G-L, Liu Z-H, Xue F, Gu Q, Ni X-H, Zhao Z-H, Cheng X-S, Wilkins MR, He J-Get al., 2012, Atorvastatin in Pulmonary Arterial Hypertension (APATH) study, EUROPEAN RESPIRATORY JOURNAL, Vol: 40, Pages: 67-74, ISSN: 0903-1936

JOURNAL ARTICLE

Zhao L, Chen C-N, Hajji N, Oliver E, Cotroneo E, Wharton J, Wang D, Li M, McKinsey TA, Stenmark KR, Wilkins MRet al., 2012, Histone Deacetylation Inhibition in Pulmonary Hypertension Therapeutic Potential of Valproic Acid and Suberoylanilide Hydroxamic Acid, CIRCULATION, Vol: 126, Pages: 455-+, ISSN: 0009-7322

JOURNAL ARTICLE

Nasim MT, Ogo T, Ahmed M, Randall R, Chowdhury HM, Snape KM, Bradshaw TY, Southgate L, Lee GJ, Jackson I, Lord GM, Gibbs JSR, Wilkins MR, Ohta-Ogo K, Nakamura K, Girerd B, Coulet F, Soubrier F, Humbert M, Morrell NW, Trembath RC, Machado RDet al., 2011, Molecular genetic characterization of SMAD signaling molecules in pulmonary arterial hypertension, HUMAN MUTATION, Vol: 32, Pages: 1385-1389, ISSN: 1059-7794

JOURNAL ARTICLE

Rhodes CJ, Howard LS, Busbridge M, Ashby D, Kondili E, Gibbs JSR, Wharton J, Wilkins MRet al., 2011, Iron Deficiency and Raised Hepcidin in Idiopathic Pulmonary Arterial Hypertension Clinical Prevalence, Outcomes, and Mechanistic Insights, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 58, Pages: 300-309, ISSN: 0735-1097

JOURNAL ARTICLE

Rhodes CJ, Wharton J, Howard L, Gibbs JSR, Vonk-Noordegraaf A, Wilkins MRet al., 2011, Iron deficiency in pulmonary arterial hypertension: a potential therapeutic target, EUROPEAN RESPIRATORY JOURNAL, Vol: 38, Pages: 1453-1460, ISSN: 0903-1936

JOURNAL ARTICLE

Rhodes CJ, Wharton J, Howard LS, Gibbs JSR, Wilkins MRet al., 2011, Red cell distribution width outperforms other potential circulating biomarkers in predicting survival in idiopathic pulmonary arterial hypertension, HEART, Vol: 97, Pages: 1054-1060, ISSN: 1355-6037

JOURNAL ARTICLE

Schermuly RT, Ghofrani HA, Wilkins MR, Grimminger Fet al., 2011, Mechanisms of disease: pulmonary arterial hypertension, NATURE REVIEWS CARDIOLOGY, Vol: 8, Pages: 443-455, ISSN: 1759-5002

JOURNAL ARTICLE

Zhai Z, Murphy K, Tighe H, Wang C, Wilkins MR, Gibbs JSR, Howard LSet al., 2011, Differences in Ventilatory Inefficiency Between Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension, CHEST, Vol: 140, Pages: 1284-1291, ISSN: 0012-3692

JOURNAL ARTICLE

Zhao L, Zhai Z, Wharton J, Wilkins MRet al., 2011, Phosphodiesterase inhibitors in the treatment of pulmonary hypertension, Textbook of pulmonary vascular disease, Editors: Yuan, Garcia, Hales, Rich, Archer, West, Publisher: Springer, Pages: 1477-1486

BOOK CHAPTER

Abdul-Salam VB, Wharton J, Cupitt J, Berryman M, Edwards RJ, Wilkins MRet al., 2010, Proteomic Analysis of Lung Tissues From Patients With Pulmonary Arterial Hypertension, CIRCULATION, Vol: 122, Pages: 2058-U282, ISSN: 0009-7322

JOURNAL ARTICLE

Archer SL, Weir EK, Wilkins MR, 2010, Basic Science of Pulmonary Arterial Hypertension for Clinicians New Concepts and Experimental Therapies, CIRCULATION, Vol: 121, Pages: 2045-U175, ISSN: 0009-7322

JOURNAL ARTICLE

Wilkins M, 2010, Pulmonary Hypertension in 6 Lessons, Publisher: KARGER, Pages: 13-14, ISSN: 0008-6312

CONFERENCE PAPER

Wilkins MR, Ali O, Bradlow W, Wharton J, Taegtmeyer A, Rhodes CJ, Ghofrani HA, Howard L, Nihoyannopoulos P, Mohiaddin RH, Gibbs JSRet al., 2010, Simvastatin as a Treatment for Pulmonary Hypertension Trial, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 181, Pages: 1106-1113, ISSN: 1073-449X

JOURNAL ARTICLE

Wilkins MR, Wharton J, Zhao L, 2010, What animal models tell us about treatments of pulmonary hypertension, Pulmonary arterial hypertension, Editors: Antel, Hesselink, Schermuly, Pages: 57-69

BOOK CHAPTER

Wilkins MR, Wharton J, Zhao L, 2010, What Animal Models Tell Us about Treatments for Pulmonary Hypertension, 10th Solvay Pharmaceuticals Conference on Pulmonary Arterial Hypertension (PAH), Publisher: IOS PRESS, Pages: 57-69, ISSN: 1566-7685

CONFERENCE PAPER

Zhai Z, Murphy K, Tighe H, Wang C, Wilkins M, Gibbs S, Howard LSet al., 2010, VENTILATORY EFFICIENCY IN PULMONARY ARTERIAL HYPERTENSION AND CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION: PHYSIOLOGICAL DIFFERENCES AND IMPLICATIONS FOR DISEASE-SPECIFIC END-POINTS, British-Thoracic-Society-Winter-Meeting 2010, Publisher: B M J PUBLISHING GROUP, Pages: A45-A46, ISSN: 0040-6376

CONFERENCE PAPER

Rhodes CJ, Davidson A, Gibbs JSR, Wharton J, Wilkins MRet al., 2009, Therapeutic targets in pulmonary arterial hypertension, PHARMACOLOGY & THERAPEUTICS, Vol: 121, Pages: 69-88, ISSN: 0163-7258

JOURNAL ARTICLE

Wilkins M, 2009, Assessing the Effects of Novel Treatments for Pulmonary Arterial Hypertension on Pulmonary Vascular and Cardiac Remodeling, Publisher: KARGER, Pages: 126-126, ISSN: 0008-6312

CONFERENCE PAPER

Zhao L, Sebkhi A, Ali O, Wojciak-Stothard B, Mamanova L, Yang Q, Wharton J, Wilkins MRet al., 2009, Simvastatin and sildenafil combine to attenuate pulmonary hypertension, EUROPEAN RESPIRATORY JOURNAL, Vol: 34, Pages: 948-957, ISSN: 0903-1936

JOURNAL ARTICLE

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