Imperial College London

Professor Martin Wilkins

Faculty of MedicineDepartment of Medicine

Head of the Department of Medicine
 
 
 
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Contact

 

+44 (0)20 3313 2049m.wilkins

 
 
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Location

 

NIHR / Wellcome Trust Clinical Research FacilityICTEM buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

180 results found

Baliga RS, Zhao L, Madhani M, Lopez-Torondel B, Visintin C, Selwood D, Wilkins MR, MacAllister RJ, Hobbs AJet al., 2008, Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 178, Pages: 861-869, ISSN: 1073-449X

JOURNAL ARTICLE

Diller G-P, van Eijl S, Okonko DO, Howard LS, Ali O, Thum T, Wort SJ, Bedard E, Gibbs JSR, Bauersachs J, Hobbs AJ, Wilkins MR, Gatzoulis MA, Wharton Jet al., 2008, Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension, CIRCULATION, Vol: 117, Pages: 3020-3030, ISSN: 0009-7322

JOURNAL ARTICLE

Michelakis ED, Wilkins MR, Rabinovitch M, 2008, Emerging concepts and translational priorities in pulmonary arterial hypertension, CIRCULATION, Vol: 118, Pages: 1486-1495, ISSN: 0009-7322

JOURNAL ARTICLE

Nickel N, Kempf T, Tapken H, Tongers J, Laenger F, Lehmann U, Golpon H, Olsson K, Wilkins MR, Gibbs JSR, Hoeper MM, Wollert KCet al., 2008, Growth differentiation factor-15 in idiopathic pulmonary arterial hypertension, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 178, Pages: 534-541, ISSN: 1073-449X

JOURNAL ARTICLE

Wilkins MR, Wharton J, Grimminger F, Ghofrani HAet al., 2008, Phosphodiesterase inhibitors for the treatment of pulmonary hypertension, EUROPEAN RESPIRATORY JOURNAL, Vol: 32, Pages: 198-209, ISSN: 0903-1936

JOURNAL ARTICLE

Ali O, Wharton J, Simon J, Gibbs R, Howard L, Wilkins MRet al., 2007, Emerging therapies for pulmonary arterial hypertension, EXPERT OPINION ON INVESTIGATIONAL DRUGS, Vol: 16, Pages: 803-818, ISSN: 1354-3784

JOURNAL ARTICLE

Bogle R, Wilkins M, 2007, Treating acute myocardial infarction: something in the wind?, LANCET, Vol: 370, Pages: 1461-1462, ISSN: 0140-6736

JOURNAL ARTICLE

Kojonazarov BK, Imanov BZ, Amatov TA, Mirrakhimov MM, Naeije R, Wilkins MR, Aldashev AAet al., 2007, Noninvasive and invasive evaluation of pulmonary arterial pressure in highlanders, EUROPEAN RESPIRATORY JOURNAL, Vol: 29, Pages: 352-356, ISSN: 0903-1936

JOURNAL ARTICLE

Kojonazarov BK, Mirrakhimov MM, Morrell NW, Wilkins MR, Aldashev AAet al., 2007, Sildenafil and hypoxic pulmonary hypertension, NATO Advanced Research Workshop on Problems of High Altitude Medicine and Biology, Publisher: SPRINGER, Pages: 133-+, ISSN: 1874-6489

CONFERENCE PAPER

Zhao L, Bahaa F, Wilkins M, 2007, Tetrarydrobiopterin and pulmonary hypertension, PROBLEMS OF HIGH ALTITUDE MEDICINE AND BIOLOGY, Pages: 69-+, ISSN: 1874-6489

JOURNAL ARTICLE

Abdul-Salam VB, Paul GA, Ali JO, Gibbs SR, Rahman D, Taylor GW, Wilkins MR, Edwards RJet al., 2006, Identification of plasma protein biomarkers associated with idiopathic pulmonary arterial hypertension, PROTEOMICS, Vol: 6, Pages: 2286-2294, ISSN: 1615-9853

JOURNAL ARTICLE

Ali O, Growcott E, Wharton J, Wilkins Met al., 2006, Statins modulate the growth of human pulmonary smooth muscle cells through the mevalonate pathway, Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, Publisher: B M J PUBLISHING GROUP, Pages: A14-A15, ISSN: 1355-6037

CONFERENCE PAPER

Machado RD, Koehler R, Glissmeyer E, Veal C, Suntharalingam J, Kim M, Carlquist J, Town M, Elliott CG, Hoeper M, Fijalkowska A, Kurzyna M, Thomson JR, Gibbs SR, Wilkins MR, Seeger W, Morrell NW, Gruenig E, Trembath RC, Janssen Bet al., 2006, Genetic association of the serotonin transporter in pulmonary arterial hypertension, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 173, Pages: 793-797, ISSN: 1073-449X

JOURNAL ARTICLE

Aldashev AA, Kojonazarov BK, Amatov TA, Sooronbaev TM, Mirrakhimov MM, Morrell NW, Wharton J, Wilkins MRet al., 2005, Phosphodiesterase type 5 and high altitude pulmonary hypertension, THORAX, Vol: 60, Pages: 683-687, ISSN: 0040-6376

JOURNAL ARTICLE

Khoo JP, Zhao L, Alp NJ, Bendall JK, Nicoli T, Rockett K, Wilkins MR, Channon KMet al., 2005, Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension, CIRCULATION, Vol: 111, Pages: 2126-2133, ISSN: 0009-7322

JOURNAL ARTICLE

Paul GA, Gibbs JSR, Boobis AR, Abbas A, Wilkins MRet al., 2005, Bosentan decreases the plasma concentration of sildenafil when coprescribed in pulmonary hypertension, BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 60, Pages: 107-112, ISSN: 0306-5251

JOURNAL ARTICLE

Phillips PG, Long L, Wilkins MR, Morrell NWet al., 2005, cAMP phosphodiesterase inhibitors potentiate effects of prostacyclin analogs in hypoxic pulmonary vascular remodeling, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol: 288, Pages: L103-L115, ISSN: 1040-0605

JOURNAL ARTICLE

Wharton J, Strange JW, Moller GMO, Growcott EJ, Ren XH, Franklyn AP, Phillips SC, Wilkins MRet al., 2005, Antiproliferative effects of phosphodiesterase type 5 inhibition in human pulmonary artery cells, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 172, Pages: 105-113, ISSN: 1073-449X

JOURNAL ARTICLE

Wilkins MR, Paul GA, Strange JW, Tunariu N, Gin-Sing W, Banya WA, Westwood MA, Stefanidis A, Ng LL, Pennell DJ, Mohiaddin RH, Nihoyannopoulos P, Gibbs JSRet al., 2005, Sildenafil versus endothelin receptor antagonist for pulmonary hypertension (SERAPH) study, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 171, Pages: 1292-1297, ISSN: 1073-449X

JOURNAL ARTICLE

Wilkins MR, 2004, Selective or nonselective endothelin receptor blockade in pulmonary arterial hypertension, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 169, Pages: 433-434, ISSN: 1073-449X

JOURNAL ARTICLE

Gibbs JSR, Wharton J, Wilkins MR, 2003, Pulmonary arterial hypertension and the vasoconstrictive factor: is there still a role for vasodilator testing?, EUROPEAN HEART JOURNAL, Vol: 24, Pages: 297-298, ISSN: 0195-668X

JOURNAL ARTICLE

Sebkhi A, Strange JW, Phillips SC, Wharton J, Wilkins MRet al., 2003, Phosphodiesterase type 5 as a target for the treatment of hypoxia-induced pulmonary hypertension, CIRCULATION, Vol: 107, Pages: 3230-3235, ISSN: 0009-7322

JOURNAL ARTICLE

Zhao L, Mason NA, Strange JW, Walker H, Wilkins MRet al., 2003, Beneficial effects of phosphodiesterase 5 inhibition in pulmonary hypertension are influenced by natriuretic peptide activity, CIRCULATION, Vol: 107, Pages: 234-237, ISSN: 0009-7322

JOURNAL ARTICLE

Aldashev AA, Sarybaev AS, Sydykov AS, Kalmyrzaev BB, Kim EV, Mamanova LB, Maripov R, Kojonazarov BK, Mirrakhimov MM, Wilkins MR, Morrell NWet al., 2002, Characterization of high-altitude pulmonary hypertension in the Kyrgyz: Association with angiotensin-converting enzyme genotype, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 166, Pages: 1396-1402, ISSN: 1073-449X

JOURNAL ARTICLE

King L, Wilkins MR, 2002, Natriuretic peptide receptors and the heart, HEART, Vol: 87, Pages: 314-315, ISSN: 1355-6037

JOURNAL ARTICLE

Strange JW, Wharton J, Phillips PG, Wilkins MRet al., 2002, Recent insights into the pathogenesis and therapeutics of pulmonary hypertension, CLINICAL SCIENCE, Vol: 102, Pages: 253-268, ISSN: 0143-5221

JOURNAL ARTICLE

Wilkins MR, Aldashev A, Morrell NW, 2002, Nitric oxide, phosphodiesterase inhibition, and adaption to hypoxic conditions, LANCET, Vol: 359, Pages: 1539-1540, ISSN: 0140-6736

JOURNAL ARTICLE

Wilkins MR, Møller GMO, Ren X, Wharton Jet al., 2002, Developments in therapeutics for pulmonary arterial hypertension., Minerva Cardioangiol, Vol: 50, Pages: 175-187, ISSN: 0026-4725

For many years, the management of pulmonary hypertension has been frustrated by an inadequate understanding of its pathology and limited therapeutic options, but this is changing rapidly. Recently, novel insight into the pathogenesis of primary pulmonary hypertension (PPH) has been provided by the demonstration of mutations in BMPR2 and ALK-1 genes in a significant number of patients with the condition. These genes encode members of the TGF-b receptor superfamily and their integrity is important in the maintenance of normal pulmonary vascular structure and function. At the same time, there has been a major advance in the treatment of the condition due to development of 2 orally active pharmacological agents, bosentan and sildenafil, which demonstrate some selectivity for the pulmonary vasculature. This review examines how the management of PPH and severe pulmonary hypertension in associated diseases has changed and looks at exciting future developments.

JOURNAL ARTICLE

Jourdan KB, Mason NA, Long L, Philips PG, Wilkins MR, Morrell NWet al., 2001, Characterization of adenylyl cyclase isoforms in rat peripheral pulmonary arteries, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol: 280, Pages: L1359-L1369, ISSN: 1040-0605

JOURNAL ARTICLE

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