176 results found
Ligueros M, Unwin RJ, Wilkins MR, et al., 1992, A comparison of the effects of the selective a-blocker terazosin with the selective b1-blocker atenolol on blood pressure control, serum lipids and exercise performance in mild-to-moderate hypertension, Clinical Autonomic Research, Vol: 2, Pages: 373-381
WILKINS MR, NEEDLEMAN P, 1992, EFFECT OF PHARMACOLOGICAL MANIPULATION OF ENDOGENOUS ATRIOPEPTIN ACTIVITY ON RENAL-FUNCTION, AMERICAN JOURNAL OF PHYSIOLOGY, Vol: 262, Pages: F161-F167, ISSN: 0002-9513
WILKINS MR, SETTLE SL, KIRK JE, et al., 1992, RESPONSE TO ATRIAL NATURIURETIC PEPTIDE, ENDOPEPTIDASE 24.11 INHIBITOR AND C-ANP RECEPTOR LIGAND IN THE RAT, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 107, Pages: 50-57, ISSN: 0007-1188
Wilkins MR, Needleman P, 1992, Effect of pharmacological manipulation of endogenous atriopeptin activity on renal function., Am J Physiol, Vol: 262, Pages: F161-F167, ISSN: 0002-9513
Atrial stretch causes the release of atriopeptin (AP, ANF) from preformed vesicular storage sites. The circulating hormone acts on unique receptor sites (containing guanylate cyclase) to release guanosine 3',5'-cyclic monophosphate (cGMP) that mediates the natriuresis and vasodilation and probably the suppression of renin, aldosterone, and vasopressin. The biological effects of atriopeptin are transient because of the rapid inactivation of the circulating hormone (by neutral endopeptidase or clearance receptors) or the second messenger (by cGMP-phosphodiesterase). Heart failure due to chronic cardiac volume overload [aortovenocaval (A-V) fistula] exhibits markedly elevated circulating AP blood levels and urinary cGMP levels, accompanied by induction of ventricular AP gene and protein expression and release. Pharmacological manipulation of endogenous AP, either by inhibiting cGMP phosphodiesterase (i.e., mediator prolongation) or neutral endopeptidase (i.e., prolongation of hormone half-life) in A-V fistula animals results in profound natriuresis and diuresis without hypotension. These pharmacological maneuvers bypass the suppressed renal response to exogenous AP seen in heart failure and provide a rational therapeutic strategy based on our understanding of the underlying physiological and pathological mechanisms.
GREENWALD JE, NEEDLEMAN P, WILKINS MR, et al., 1991, RENAL SYNTHESIS OF ATRIOPEPTIN-LIKE PROTEIN IN PHYSIOLOGY AND PATHOPHYSIOLOGY, AMERICAN JOURNAL OF PHYSIOLOGY, Vol: 260, Pages: F602-F607, ISSN: 0002-9513
Greenwald JE, Needleman P, Wilkins MR, et al., 1991, Renal atriopeptin synthesis in rats in physiology and pathophysiology, American Journal of Physiology, Vol: 260, Pages: 602-607
Greenwald JE, Needleman P, Wilkins MR, et al., 1991, Renal synthesis of atriopeptin-like protein in physiology and pathophysiology., Am J Physiol, Vol: 260, Pages: F602-F607, ISSN: 0002-9513
Atriopeptin is synthesized in mammalian atria as a 126-amino acid (14 kDa) prohormone, but it is secreted and circulates as a 28-amino acid (2.5 kDa) peptide. We have demonstrated the synthesis and secretion of an atriopeptin-like peptide in neonatal and adult rat kidney cell cultures. In this study, we evaluated the site of renal synthesis of this protein and its expression in normal rats and rats made nephrotic with puromycin aminonucleoside. The major form of atriopeptin in normal kidneys comigrated with an apparent molecular mass of 2.5 kDa assessed by gel filtration chromatography. However, the major form of this atriopeptin-like protein in nephrotic kidneys was determined to have an apparent molecular mass similar to the heart prohormone. No atriopeptin prohormone was detected in the plasma of nephrotic rats. Localization of this renal atriopeptin-like protein was accomplished by immunocytochemistry of rat kidney frozen sections. Using an antibody generated against either the COOH-terminal or NH3-terminal region of the cardiac atriopeptin prohormone, we detected specific immunostaining in the distal cortical nephron of the nephrotic kidney. This is the first report of the anatomic localization of a renal atriopeptin-like protein and its upregulation in nephrosis.
Ligueros M, Unwin R, Wilkins M, 1991, Selective alpha 1-adrenoreceptor blockers in the treatment of hypertension: should we be using them more?, Clin Auton Res, Vol: 1, Pages: 251-258, ISSN: 0959-9851
It has become apparent in recent years that in the treatment of essential hypertension, reduction of blood pressure alone is not sufficient to reduce significantly the morbidity and mortality from ischaemic heart disease. Since the emergence of a multifactorial approach to the prevention of cardiovascular disease, the potential interaction between antihypertensive therapy and metabolic factors, such as control of blood glucose and lipid levels, has become an important consideration. Abnormal function of the sympathetic nervous system may contribute to both the initiation, or maintenance, of hypertension and the associated metabolic disturbances. The new generation of selective alpha 1-adrenoreceptor blockers, besides lowering blood pressure, appear to have favourable effects on lipid and glucose metabolism. The use of these drugs and their place in the treatment of hypertension are discussed.
YAN Q, SETTLE SL, WILKINS MR, 1991, HYPOTENSION INDUCED BY INTRAVASCULAR ADMINISTRATION OF NERVE GROWTH-FACTOR IN THE RAT, CLINICAL SCIENCE, Vol: 80, Pages: 565-569, ISSN: 0143-5221
GREENWALD JE, NEEDLEMAN P, WILKINS M, et al., 1990, RENAL SYNTHESIS OF ATRIOPEPTIN IN PHYSIOLOGY AND PATHO-PHYSIOLOGY, Publisher: BLACKWELL SCIENCE INC, Pages: 339-339, ISSN: 0085-2538
TOKI Y, ITO T, SHIONO S, et al., 1990, ALTERNATIVE MECHANISMS FOR ATRIOPEPTIN PROHORMONE PROCESSING BY ISOLATED PERFUSED RAT HEARTS, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 254, Pages: 228-235, ISSN: 0022-3565
WILKINS MR, SETTLE SL, NEEDLEMAN P, 1990, AUGMENTATION OF THE NATRIURETIC ACTIVITY OF EXOGENOUS AND ENDOGENOUS ATRIOPEPTIN IN RATS BY INHIBITION OF GUANOSINE 3',5'-CYCLIC-MONOPHOSPHATE DEGRADATION, JOURNAL OF CLINICAL INVESTIGATION, Vol: 85, Pages: 1274-1279, ISSN: 0021-9738
WILKINS MR, SETTLE SL, STOCKMANN PT, et al., 1990, MAXIMIZING THE NATRIURETIC EFFECT OF ENDOGENOUS ATRIOPEPTIN IN A RAT MODEL OF HEART-FAILURE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 87, Pages: 6465-6469, ISSN: 0027-8424
LEWIS HM, RATCLIFFE WA, STOTT RAW, et al., 1989, DEVELOPMENT AND VALIDATION OF A 2-SITE IMMUNORADIOMETRIC ASSAY FOR HUMAN ATRIAL NATRIURETIC FACTOR IN UNEXTRACTED PLASMA, CLINICAL CHEMISTRY, Vol: 35, Pages: 953-957, ISSN: 0009-9147
LEWIS HM, WILKINS MR, KENDALL MJ, et al., 1989, CARBIDOPA DOES NOT AFFECT THE RENAL RESPONSE TO ATRIAL NATRIURETIC FACTOR IN MAN, CLINICAL SCIENCE, Vol: 77, Pages: 281-285, ISSN: 0143-5221
Lewis H, Wilkins M, Selwyn B, et al., 1989, Relationship between ANP, cyclic GMP and tissue kallikrein following saline infusion in healthy volunteers., Adv Exp Med Biol, Vol: 247A, Pages: 281-286, ISSN: 0065-2598
Infusion of saline in healthy volunteers produced a significant rise in plasma atrial natriuretic peptide, which was accompanied by the urinary excretion of cyclic GMP and sodium. Although the time-course of cyclic GMP excretion almost mirrored that of plasma ANP, that of sodium showed sustained phase, indicating involvement of additional humoral regulators. ANP did not stimulate the excretion of enzymic or immunoreactive tissue kallikrein.
Lewis HM, Wilkins MR, Kendall MJ, et al., 1989, Carbidopa does not affect the renal response to atrial natriuretic factor in man, Clinical Science, Vol: 73, Pages: 281-285
WILKINS MR, STOTT RAW, LEWIS HM, 1989, ATRIAL NATRIURETIC FACTOR, ANNALS OF CLINICAL BIOCHEMISTRY, Vol: 26, Pages: 115-118, ISSN: 0004-5632
LEWIS HM, WILKINS MR, SELWYN BM, et al., 1988, URINARY GUANOSINE 3'-5'-CYCLIC MONOPHOSPHATE BUT NOT TISSUE KALLIKREIN FOLLOWS THE PLASMA ATRIAL NATRIURETIC FACTOR RESPONSE TO ACUTE VOLUME EXPANSION WITH SALINE, CLINICAL SCIENCE, Vol: 75, Pages: 489-494, ISSN: 0143-5221
WILKINS MR, GAMMAGE MD, LEWIS HM, et al., 1988, EFFECT OF LOWER BODY POSITIVE PRESSURE ON BLOOD-PRESSURE, PLASMA ATRIAL NATRIURETIC FACTOR CONCENTRATION, AND SODIUM AND WATER-EXCRETION IN HEALTHY-VOLUNTEERS AND CARDIAC TRANSPLANT RECIPIENTS, CARDIOVASCULAR RESEARCH, Vol: 22, Pages: 231-235, ISSN: 0008-6363
BEERAHEE M, WILKINS MR, JACK DB, et al., 1987, 12 HOUR (TROUGH) PLASMA NIFEDIPINE CONCENTRATIONS DURING CHRONIC TREATMENT WITH NIFEDIPINE-RETARD, EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 32, Pages: 347-349, ISSN: 0031-6970
Beerahee M, Wilkins MR, Jack DB, et al., 1987, Twelve hour (tough) plasma nifedipine concentrations during chronic treatment with nifedipine retard, European Journal of Clinical Pharmacology, Vol: 32, Pages: 347-349
SMITH SR, KENDALL MJ, LOBO J, et al., 1987, RANITIDINE AND CIMETIDINE - DRUG-INTERACTIONS WITH SINGLE DOSE AND STEADY-STATE NIFEDIPINE ADMINISTRATION, BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 23, Pages: 311-315, ISSN: 0306-5251
SMITH SR, WILKINS MR, JACK DB, et al., 1987, PHARMACOKINETIC INTERACTIONS BETWEEN FELODIPINE AND METOPROLOL, EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 31, Pages: 575-578, ISSN: 0031-6970
WILKINS MR, GAMMAGE MD, LEWIS HM, et al., 1987, RAISED CONCENTRATIONS OF PLASMA ATRIAL NATRIURETIC PEPTIDES IN CARDIAC TRANSPLANT RECIPIENTS, BRITISH MEDICAL JOURNAL, Vol: 294, Pages: 122-122, ISSN: 0959-8138
WILKINS MR, LEWIS HM, WEST MJ, et al., 1987, CAPTOPRIL REDUCES THE RENAL RESPONSE TO INTRAVENOUS ATRIAL NATRIURETIC PEPTIDE IN NORMOTENSIVES, JOURNAL OF HUMAN HYPERTENSION, Vol: 1, Pages: 47-51, ISSN: 0950-9240
JENNINGS PE, WILKINS MR, WEST MJ, et al., 1986, SODIUM-TRANSPORT ACROSS ERYTHROCYTE-MEMBRANES IN DIABETES-MELLITUS, DIABETES RESEARCH CLINICAL AND EXPERIMENTAL, Vol: 3, Pages: 407-410, ISSN: 0265-5985
KENDALL MJ, LOBO J, WILKINS MR, 1986, RANITIDINE, CIMETIDINE AND NIFEDIPINE - A PHARMACOKINETIC INTERACTION STUDY, GASTROENTEROLOGY, Vol: 90, Pages: 1490-1490, ISSN: 0016-5085
WILKINS MR, GAMMAGE MD, TAN LB, et al., 1986, EFFECT OF LOWER-BODY POSITIVE PRESSURE ON ATRIAL DIMENSION AND PLASMA ATRIAL-NATRIURETIC-PEPTIDE CONCENTRATION, JOURNAL OF HYPERTENSION, Vol: 4, Pages: S500-S502, ISSN: 0263-6352
WILKINS MR, GOVE RI, ROBERTS SD, et al., 1986, BEHCETS-DISEASE PRESENTING AS BENIGN INTRACRANIAL HYPERTENSION, POSTGRADUATE MEDICAL JOURNAL, Vol: 62, Pages: 39-41, ISSN: 0032-5473
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