Imperial College London

Professor Martin Wilkins

Faculty of MedicineDepartment of Medicine

Head of the Department of Medicine
 
 
 
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Contact

 

+44 (0)20 3313 2049m.wilkins

 
 
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Location

 

NIHR / Wellcome Trust Clinical Research FacilityICTEM buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

180 results found

CLESHAM GJ, KENNEDY A, LAVENDER JP, DOLLERY CT, WILKINS MRet al., 1993, METAIODOBENZYLGUANIDINE (METAIODOBENZYLGUANIDINE) SCANNING IN THE DIAGNOSIS OF PHEOCHROMOCYTOMA, JOURNAL OF HUMAN HYPERTENSION, Vol: 7, Pages: 353-356, ISSN: 0950-9240

JOURNAL ARTICLE

Clesham CJ, Kennedy A, Lavender JP, Dollery CT, Wilkins MRet al., 1993, Meta-iodobenzylguanidine (MIBG) scanning in the diagnosis of phaeochromocytoma., J Hum Hypertens, Vol: 7, Pages: 353-356, ISSN: 0950-9240

During the period 1984-90, meta-iodobenzylguanidine (MIBG) scans were performed in 23 patients with suspected phaeochromocytoma seen at the Hammersmith Hospital. Sixteen patients had a histologically proven phaeochromocytoma and in 14 of these patients the tumour was demonstrated by abnormal uptake of MIBG. Seven patients did not have a phaeochromocytoma and in all of these the MIBG scan was negative. These findings gave the procedure a sensitivity of 87.5% with a specificity of 100%; positive and negative predictive values were 100% and 77.7%, respectively. MIBG scanning is an extremely valuable technique in the management of patients with suspected phaeochromocytoma but is best employed to localise a tumour which has been confirmed biochemically.

JOURNAL ARTICLE

Kirk JE, Wilkins MR, 1993, Effect of endopeptidase-24.11 inhibition and atrial natriuretic peptide clearance receptor ligand on the response to rat brain natriuretic peptide in the conscious rat, British Journal of Pharmacology, Vol: 110, Pages: 350-354

JOURNAL ARTICLE

Ligueros M, Unwin R, Wilkins MR, Humphreys J, Coles SJ, Cleland Jet al., 1992, A comparison of the effects of the selective peripheral alpha 1-blocker terazosin with the selective beta 1-blocker atenolol on blood pressure, exercise performance and the lipid profile in mild-to-moderate essential hypertension., Clin Auton Res, Vol: 2, Pages: 373-381, ISSN: 0959-9851

The effects of six weeks of treatment with the selective peripheral alpha 1-adrenoceptor blocker terazosin, or the selective beta 1-adrenoceptor blocker atenolol on blood pressure, exercise performance and blood lipid profile were compared in a single-blind, randomized, crossover study of 17 patients with mild-to-moderate essential hypertension. Although both drugs significantly reduced blood pressure at rest, atenolol caused a larger fall in supine blood pressure (11/11 and 7.5/7.0 mmHg, atenolol and terazosin, respectively; p < 0.001). Both treatments controlled the pressor response to exercise, although a greater reduction in diastolic blood pressure was observed at the end of exercise on terazosin (74.0 +/- 5.7 and 91.6 +/- 4.0 mmHg, terazosin and atenolol, respectively; p < 0.01). Alpha 1-blocker therapy was not associated with any measurable improvement or deterioration in cardiopulmonary performance and exercise duration. Unlike atenolol, terazosin therapy had the potentially beneficial effect of reducing serum total cholesterol levels and increasing the high-density lipoprotein-cholesterol/low-density lipoprotein-cholesterol ratio.

JOURNAL ARTICLE

Ligueros M, Unwin RJ, Wilkins MR, Humphreys J, Coles SJ, JGF Cet al., 1992, A comparison of the effects of the selective a-blocker terazosin with the selective b1-blocker atenolol on blood pressure control, serum lipids and exercise performance in mild-to-moderate hypertension, Clinical Autonomic Research, Vol: 2, Pages: 373-381

JOURNAL ARTICLE

WILKINS MR, NEEDLEMAN P, 1992, EFFECT OF PHARMACOLOGICAL MANIPULATION OF ENDOGENOUS ATRIOPEPTIN ACTIVITY ON RENAL-FUNCTION, AMERICAN JOURNAL OF PHYSIOLOGY, Vol: 262, Pages: F161-F167, ISSN: 0002-9513

JOURNAL ARTICLE

WILKINS MR, SETTLE SL, KIRK JE, TAYLOR SA, MOORE KP, UNWIN RJet al., 1992, RESPONSE TO ATRIAL NATURIURETIC PEPTIDE, ENDOPEPTIDASE 24.11 INHIBITOR AND C-ANP RECEPTOR LIGAND IN THE RAT, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 107, Pages: 50-57, ISSN: 0007-1188

JOURNAL ARTICLE

Wilkins MR, Needleman P, 1992, Effect of pharmacological manipulation of endogenous atriopeptin activity on renal function., Am J Physiol, Vol: 262, Pages: F161-F167, ISSN: 0002-9513

Atrial stretch causes the release of atriopeptin (AP, ANF) from preformed vesicular storage sites. The circulating hormone acts on unique receptor sites (containing guanylate cyclase) to release guanosine 3',5'-cyclic monophosphate (cGMP) that mediates the natriuresis and vasodilation and probably the suppression of renin, aldosterone, and vasopressin. The biological effects of atriopeptin are transient because of the rapid inactivation of the circulating hormone (by neutral endopeptidase or clearance receptors) or the second messenger (by cGMP-phosphodiesterase). Heart failure due to chronic cardiac volume overload [aortovenocaval (A-V) fistula] exhibits markedly elevated circulating AP blood levels and urinary cGMP levels, accompanied by induction of ventricular AP gene and protein expression and release. Pharmacological manipulation of endogenous AP, either by inhibiting cGMP phosphodiesterase (i.e., mediator prolongation) or neutral endopeptidase (i.e., prolongation of hormone half-life) in A-V fistula animals results in profound natriuresis and diuresis without hypotension. These pharmacological maneuvers bypass the suppressed renal response to exogenous AP seen in heart failure and provide a rational therapeutic strategy based on our understanding of the underlying physiological and pathological mechanisms.

JOURNAL ARTICLE

GREENWALD JE, NEEDLEMAN P, WILKINS MR, SCHREINER GFet al., 1991, RENAL SYNTHESIS OF ATRIOPEPTIN-LIKE PROTEIN IN PHYSIOLOGY AND PATHOPHYSIOLOGY, AMERICAN JOURNAL OF PHYSIOLOGY, Vol: 260, Pages: F602-F607, ISSN: 0002-9513

JOURNAL ARTICLE

Greenwald JE, Needleman P, Wilkins MR, Schreiner GFet al., 1991, Renal atriopeptin synthesis in rats in physiology and pathophysiology, American Journal of Physiology, Vol: 260, Pages: 602-607

JOURNAL ARTICLE

Greenwald JE, Needleman P, Wilkins MR, Schreiner GFet al., 1991, Renal synthesis of atriopeptin-like protein in physiology and pathophysiology., Am J Physiol, Vol: 260, Pages: F602-F607, ISSN: 0002-9513

Atriopeptin is synthesized in mammalian atria as a 126-amino acid (14 kDa) prohormone, but it is secreted and circulates as a 28-amino acid (2.5 kDa) peptide. We have demonstrated the synthesis and secretion of an atriopeptin-like peptide in neonatal and adult rat kidney cell cultures. In this study, we evaluated the site of renal synthesis of this protein and its expression in normal rats and rats made nephrotic with puromycin aminonucleoside. The major form of atriopeptin in normal kidneys comigrated with an apparent molecular mass of 2.5 kDa assessed by gel filtration chromatography. However, the major form of this atriopeptin-like protein in nephrotic kidneys was determined to have an apparent molecular mass similar to the heart prohormone. No atriopeptin prohormone was detected in the plasma of nephrotic rats. Localization of this renal atriopeptin-like protein was accomplished by immunocytochemistry of rat kidney frozen sections. Using an antibody generated against either the COOH-terminal or NH3-terminal region of the cardiac atriopeptin prohormone, we detected specific immunostaining in the distal cortical nephron of the nephrotic kidney. This is the first report of the anatomic localization of a renal atriopeptin-like protein and its upregulation in nephrosis.

JOURNAL ARTICLE

Ligueros M, Unwin R, Wilkins M, 1991, Selective alpha 1-adrenoreceptor blockers in the treatment of hypertension: should we be using them more?, Clin Auton Res, Vol: 1, Pages: 251-258, ISSN: 0959-9851

It has become apparent in recent years that in the treatment of essential hypertension, reduction of blood pressure alone is not sufficient to reduce significantly the morbidity and mortality from ischaemic heart disease. Since the emergence of a multifactorial approach to the prevention of cardiovascular disease, the potential interaction between antihypertensive therapy and metabolic factors, such as control of blood glucose and lipid levels, has become an important consideration. Abnormal function of the sympathetic nervous system may contribute to both the initiation, or maintenance, of hypertension and the associated metabolic disturbances. The new generation of selective alpha 1-adrenoreceptor blockers, besides lowering blood pressure, appear to have favourable effects on lipid and glucose metabolism. The use of these drugs and their place in the treatment of hypertension are discussed.

JOURNAL ARTICLE

YAN Q, SETTLE SL, WILKINS MR, 1991, HYPOTENSION INDUCED BY INTRAVASCULAR ADMINISTRATION OF NERVE GROWTH-FACTOR IN THE RAT, CLINICAL SCIENCE, Vol: 80, Pages: 565-569, ISSN: 0143-5221

JOURNAL ARTICLE

GREENWALD JE, NEEDLEMAN P, WILKINS M, SCHREINER GFet al., 1990, RENAL SYNTHESIS OF ATRIOPEPTIN IN PHYSIOLOGY AND PATHO-PHYSIOLOGY, Publisher: BLACKWELL SCIENCE INC, Pages: 339-339, ISSN: 0085-2538

CONFERENCE PAPER

TOKI Y, ITO T, SHIONO S, SIEGEL NR, GIERSE JK, WILKINS MR, NEEDLEMAN Pet al., 1990, ALTERNATIVE MECHANISMS FOR ATRIOPEPTIN PROHORMONE PROCESSING BY ISOLATED PERFUSED RAT HEARTS, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 254, Pages: 228-235, ISSN: 0022-3565

JOURNAL ARTICLE

WILKINS MR, SETTLE SL, NEEDLEMAN P, 1990, AUGMENTATION OF THE NATRIURETIC ACTIVITY OF EXOGENOUS AND ENDOGENOUS ATRIOPEPTIN IN RATS BY INHIBITION OF GUANOSINE 3',5'-CYCLIC-MONOPHOSPHATE DEGRADATION, JOURNAL OF CLINICAL INVESTIGATION, Vol: 85, Pages: 1274-1279, ISSN: 0021-9738

JOURNAL ARTICLE

WILKINS MR, SETTLE SL, STOCKMANN PT, NEEDLEMAN Pet al., 1990, MAXIMIZING THE NATRIURETIC EFFECT OF ENDOGENOUS ATRIOPEPTIN IN A RAT MODEL OF HEART-FAILURE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 87, Pages: 6465-6469, ISSN: 0027-8424

JOURNAL ARTICLE

LEWIS HM, RATCLIFFE WA, STOTT RAW, WILKINS MR, BAYLIS PHet al., 1989, DEVELOPMENT AND VALIDATION OF A 2-SITE IMMUNORADIOMETRIC ASSAY FOR HUMAN ATRIAL NATRIURETIC FACTOR IN UNEXTRACTED PLASMA, CLINICAL CHEMISTRY, Vol: 35, Pages: 953-957, ISSN: 0009-9147

JOURNAL ARTICLE

LEWIS HM, WILKINS MR, KENDALL MJ, LEE MRet al., 1989, CARBIDOPA DOES NOT AFFECT THE RENAL RESPONSE TO ATRIAL NATRIURETIC FACTOR IN MAN, CLINICAL SCIENCE, Vol: 77, Pages: 281-285, ISSN: 0143-5221

JOURNAL ARTICLE

Lewis H, Wilkins M, Selwyn B, Yelland U, Griffith M, Bhoola KDet al., 1989, Relationship between ANP, cyclic GMP and tissue kallikrein following saline infusion in healthy volunteers., Adv Exp Med Biol, Vol: 247A, Pages: 281-286, ISSN: 0065-2598

Infusion of saline in healthy volunteers produced a significant rise in plasma atrial natriuretic peptide, which was accompanied by the urinary excretion of cyclic GMP and sodium. Although the time-course of cyclic GMP excretion almost mirrored that of plasma ANP, that of sodium showed sustained phase, indicating involvement of additional humoral regulators. ANP did not stimulate the excretion of enzymic or immunoreactive tissue kallikrein.

JOURNAL ARTICLE

Lewis HM, Wilkins MR, Kendall MJ, Lee MRet al., 1989, Carbidopa does not affect the renal response to atrial natriuretic factor in man, Clinical Science, Vol: 73, Pages: 281-285

JOURNAL ARTICLE

WILKINS MR, STOTT RAW, LEWIS HM, 1989, ATRIAL NATRIURETIC FACTOR, ANNALS OF CLINICAL BIOCHEMISTRY, Vol: 26, Pages: 115-118, ISSN: 0004-5632

JOURNAL ARTICLE

LEWIS HM, WILKINS MR, SELWYN BM, YELLAND UJ, GRIFFITH ME, BHOOLA KDet al., 1988, URINARY GUANOSINE 3'-5'-CYCLIC MONOPHOSPHATE BUT NOT TISSUE KALLIKREIN FOLLOWS THE PLASMA ATRIAL NATRIURETIC FACTOR RESPONSE TO ACUTE VOLUME EXPANSION WITH SALINE, CLINICAL SCIENCE, Vol: 75, Pages: 489-494, ISSN: 0143-5221

JOURNAL ARTICLE

WILKINS MR, GAMMAGE MD, LEWIS HM, TAN LB, WEISSBERG PLet al., 1988, EFFECT OF LOWER BODY POSITIVE PRESSURE ON BLOOD-PRESSURE, PLASMA ATRIAL NATRIURETIC FACTOR CONCENTRATION, AND SODIUM AND WATER-EXCRETION IN HEALTHY-VOLUNTEERS AND CARDIAC TRANSPLANT RECIPIENTS, CARDIOVASCULAR RESEARCH, Vol: 22, Pages: 231-235, ISSN: 0008-6363

JOURNAL ARTICLE

BEERAHEE M, WILKINS MR, JACK DB, BEEVERS DG, KENDALL MJet al., 1987, 12 HOUR (TROUGH) PLASMA NIFEDIPINE CONCENTRATIONS DURING CHRONIC TREATMENT WITH NIFEDIPINE-RETARD, EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 32, Pages: 347-349, ISSN: 0031-6970

JOURNAL ARTICLE

Beerahee M, Wilkins MR, Jack DB, Beevers DG, Kendall MJet al., 1987, Twelve hour (tough) plasma nifedipine concentrations during chronic treatment with nifedipine retard, European Journal of Clinical Pharmacology, Vol: 32, Pages: 347-349

JOURNAL ARTICLE

SMITH SR, KENDALL MJ, LOBO J, BEERAHEE A, JACK DB, WILKINS MRet al., 1987, RANITIDINE AND CIMETIDINE - DRUG-INTERACTIONS WITH SINGLE DOSE AND STEADY-STATE NIFEDIPINE ADMINISTRATION, BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 23, Pages: 311-315, ISSN: 0306-5251

JOURNAL ARTICLE

SMITH SR, WILKINS MR, JACK DB, KENDALL MJ, LAUGHER Set al., 1987, PHARMACOKINETIC INTERACTIONS BETWEEN FELODIPINE AND METOPROLOL, EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 31, Pages: 575-578, ISSN: 0031-6970

JOURNAL ARTICLE

WILKINS MR, GAMMAGE MD, LEWIS HM, TAN LBet al., 1987, RAISED CONCENTRATIONS OF PLASMA ATRIAL NATRIURETIC PEPTIDES IN CARDIAC TRANSPLANT RECIPIENTS, BRITISH MEDICAL JOURNAL, Vol: 294, Pages: 122-122, ISSN: 0959-8138

JOURNAL ARTICLE

WILKINS MR, LEWIS HM, WEST MJ, KENDALL MJ, LOTE CJet al., 1987, CAPTOPRIL REDUCES THE RENAL RESPONSE TO INTRAVENOUS ATRIAL NATRIURETIC PEPTIDE IN NORMOTENSIVES, JOURNAL OF HUMAN HYPERTENSION, Vol: 1, Pages: 47-51, ISSN: 0950-9240

JOURNAL ARTICLE

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