Professor Martin Wilkins

Faculty of Medicine, National Heart & Lung Institute

Professor of Clinical Pharmacology

Contact

+44 (0)20 3313 6101m.wilkins Website

Assistant

Mrs Elizabeth O'Brien +44 (0)20 3313 6101

Location

NIHR Imperial Clinical Research FacilityICTEM buildingHammersmith Campus

Summary

Martin R. Wilkins is Professor of Clinical Pharmacology at Imperial College London. He is the Director of the British Heart Foundation Imperial College Centre of Research Excellence and Director of the National Institute for Health and Care Research (NIHR) Imperial Clinical Research Facility at Hammersmith Hospital.

His BHF-funded Travelling Fellowship to St Louis USA in 1987 provided the platform for his subsequent career in cardiovascular research. For the past 30 years he has led a bench-to-bedside programme investigating the molecular basis of pulmonary hypertension and evaluating new treatments. His work, supported throughout by the British Heart Foundation, has contributed to the development of two new classes of drug for pulmonary hypertension, namely phosphodiesterase inhibitors and soluble guanylate cyclase stimulators. His current work uses genetics, proteomics and metabolomics to define disease pathways in patients with pulmonary arterial hypertension with the aim of identifying novel druggable targets and personalised medicines. He is developing a treatment based on inhibition of zinc transport and leading a study evaluating the place of Imatinib in the management of pulmonary arterial hypertension using a novel trial design.

He was elected to the UK Academy of Medical Sciences in 2015. In 2023 he was awarded a Doctor of Science degree (DSc) from Imperial College and an honorary fellowship from the Faculty of Pharmaceutical Medicine. He is Past-President of the Pulmonary Vascular Research Institute, a global network of experts in the field (http://www.pvrinstitute.org).

Selected Publications

Journal Articles

Tai Y-Y, Yu Q, Tang Y, et al.Tai Y-Y, Yu Q, Tang Y, Sun W, Kelly NJ, Okawa S, Zhao J, Schwantes-An T-H, Lacoux C, Torrino S, Al Aaraj Y, El Khoury W, Negi V, Liu M, Corey CG, Belmonte F, Vargas SO, Schwartz B, Bhat B, Chau BN, Karnes JH, Satoh T, Barndt RJ, Wu H, Parikh VN, Wang J, Zhang Y, McNamara D, Li G, Speyer G, Wang B, Shiva S, Kaufman B, Kim S, Gomez D, Mari B, Cho MH, Boueiz A, Pauciulo MW, Southgate L, Trembath RC, Sitbon O, Humbert M, Graf S, Morrell NW, Rhodes CJ, Wilkins MR, Nouraie M, Nichols WC, Desai AA, Bertero T, Chan SY close, 2024, Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension., Sci Transl Med, Vol:16

Ulrich A, Wu Y, Draisma H, et al.Ulrich A, Wu Y, Draisma H, Wharton J, Swietlik EM, Cebola I, Vasilaki E, Balkhiyarova Z, Jarvelin M-R, Auvinen J, Herzig K-H, Coghlan JG, Lordan J, Church C, Howard LS, Pepke-Zaba J, Toshner M, Wort SJ, Kiely DG, Condliffe R, Lawrie A, Gräf S, Morrell NW, Wilkins MR, Prokopenko I, Rhodes CJ close, 2024, Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension., Nat Commun, Vol:15

Chen C-N, Hajji N, Yeh F-C, et al.Chen C-N, Hajji N, Yeh F-C, Rahman S, Ali S, Wharton J, Baxan N, Zhao L, Xie C-Y, Chen Y-G, Frid MG, Chelladurai P, Pullamsetti SS, Stenmark KR, Wilkins MR, Zhao L close, 2023, Restoration of Foxp31 Regulatory T Cells by HDAC-Dependent Epigenetic Modulation Plays a Pivotal Role in Resolving Pulmonary Arterial Hypertension Pathology, American Journal of Respiratory and Critical Care Medicine, Vol:208, ISSN:1073-449X, Pages:879-895

Shah M, Inacio M, Lu C, et al.Shah M, Inacio M, Lu C, Schiratti P-R, Zheng S, Clement A, Simoes Monteiro de Marvao A, Bai W, King A, Ware J, Wilkins M, Mielke J, Elci E, Kryukov I, McGurk K, Bender C, Freitag D, O'Regan D close, 2023, Environmental and genetic predictors of human cardiovascular ageing, Nature Communications, Vol:14, ISSN:2041-1723, Pages:1-15

Guignabert C, Savale L, Boucly A, et al.Guignabert C, Savale L, Boucly A, Thuillet R, Tu L, Ottaviani M, Rhodes CJ, De Groote P, Prevot G, Bergot E, Bourdin A, Howard LS, Fadel E, Beurnier A, Roche A, Jevnikar M, Jais X, Montani D, Wilkins MR, Sitbon O, Humbert M close, 2023, Serum and Pulmonary Expression Profiles of the Activin Signaling System in Pulmonary Arterial Hypertension, Circulation, Vol:147, ISSN:0009-7322, Pages:1809-1822

Walters R, Vasilaki E, Aman J, et al.Walters R, Vasilaki E, Aman J, Chen C-N, Wu Y, Liang OD, Ashek A, Dubois O, Zhao L, Sabrin F, Cebola I, Ferrer J, Morrell NW, Klinger JR, Wilkins MR, Zhao L, Rhodes CJ close, 2023, <i>SOX17</i> Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension, Circulation, Vol:147, ISSN:0009-7322, Pages:1606-1621

Boucly A, Tu L, Guignabert C, et al.Boucly A, Tu L, Guignabert C, Rhodes C, De Groote P, Prevot G, Bergot E, Bourdin A, Beurnier A, Roche A, Jevnikar M, Jais X, Montani D, Wilkins MR, Humbert M, Sitbon O, Savale L close, 2023, Cytokines as prognostic biomarkers in pulmonary arterial hypertension, European Respiratory Journal, Vol:61, ISSN:0903-1936

Alzaydi M, Abdul Salam V, Whitwell H, et al.Alzaydi M, Abdul Salam V, Whitwell H, Russomanno G, Glynos A, Capece D, Szabadkai G, Wilkins M, Wojciak Stothard B, Wojciak-Stothard B close, 2023, Intracellular chloride channels regulate endothelial metabolic reprogramming in pulmonary arterial hypertension, American Journal of Respiratory Cell and Molecular Biology, Vol:63, ISSN:1044-1549, Pages:103-115

Wilkins MR, 2022, Pulmonary Hypertension Dissecting a Complex Phenotype, Journal of the American College of Cardiology, Vol:80, ISSN:0735-1097, Pages:719-721

Rhodes C, Wharton J, Swietlik E, et al.Rhodes C, Wharton J, Swietlik E, Harbaum L, Girerd B, Coghlan G, Lordan J, Church C, Pepke-Zaba J, Toshner M, Wort SJ, Kiely D, Condliffe R, Lawrie A, Graf S, Montani D, Boucly A, Sitbon O, Humbert M, Howard LS, Morrell NW, Wilkins MR close, 2022, Using the plasma proteome for risk stratifying patients with pulmonary arterial hypertension, American Journal of Respiratory and Critical Care Medicine, Vol:205, ISSN:1073-449X, Pages:1102-1111

Thanaj M, Mielke J, McGurk K, et al.Thanaj M, Mielke J, McGurk K, Bai W, Savioli N, Simoes Monteiro de Marvao A, Meyer H, Zeng L, Sohler F, Lumbers T, Wilkins M, Ware J, Bender C, Rueckert D, MacNamara A, Freitag D, O'Regan D close, 2022, Genetic and environmental determinants of diastolic heart function, Nature Cardiovascular Research, Vol:1, ISSN:2731-0590, Pages:361-371

Harbaum L, Rhodes CJ, Wharton J, et al.Harbaum L, Rhodes CJ, Wharton J, Lawrie A, Karnes JH, Desai AA, Nichols WC, Humbert M, Montani D, Girerd B, Sitbon O, Boehm M, Novoyatleva T, Schermuly RT, Ghofrani HA, Toshner M, Kiely DG, Howard LS, Swietlik EM, Gräf S, Pietzner M, Morrell NW, Wilkins MR close, 2022, Mining the plasma proteome for insights into the molecular pathology of pulmonary arterial hypertension., American Journal of Respiratory and Critical Care Medicine, Vol:205, ISSN:1073-449X, Pages:1-12

Kariotis S, Jammeh E, Swietlik EM, et al.Kariotis S, Jammeh E, Swietlik EM, Pickworth JA, Rhodes CJ, Otero P, Wharton J, Iremonger J, Dunning MJ, Pandya D, Mascarenhas TS, Errington N, Thompson AAR, Romanoski CE, Rischard F, Garcia JGN, Yuan JX-J, An T-HS, Desai AA, Coghlan G, Lordan J, Corris PA, Howard LS, Condliffe R, Kiely DG, Church C, Pepke-Zaba J, Toshner M, Wort S, Graf S, Morrell NW, Wilkins MR, Lawrie A, Wang D, Bleda M, Bleda M, Hadinnapola C, Haimel M, Auckland K, Tilly T, Martin JM, Yates K, Treacy CM, Day M, Greenhalgh A, Shipley D, Peacock AJ, Irvine V, Kennedy F, Moledina S, MacDonald L, Tamvaki E, Barnes A, Cookson V, Chentouf L, Ali S, Othman S, Ranganathan L, Gibbs JSR, DaCosta R, Pinguel J, Dormand N, Parker A, Stokes D, Ghedia D, Tan Y, Ngcozana T, Wanjiku I, Polwarth G, Mackenzie Ross RV, Suntharalingam J, Grover M, Kirby A, Grove A, White K, Seatter A, Creaser-Myers A, Walker S, Roney S, Elliot CA, Charalampopoulos A, Sabroe I, Hameed A, Armstrong I, Hamilton N, Rothman AMK, Swift AJ, Wild JM, Soubrier F, Eyries M, Humbert M, Montani D, Girerd B, Scelsi L, Ghio S, Gall H, Ghofrani A, Bogaard HJ, Noordegraaf AV, Houweling AC, Veld AHI, Schotte G close, 2021, Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood, Nature Communications, Vol:12, ISSN:2041-1723, Pages:1-14

Toshner M, Church C, Harbaum L, et al.Toshner M, Church C, Harbaum L, Rhodes C, Villar Moreschi SS, Liley J, Jones R, Arora A, Batai K, Desai AA, Coghlan JG, Gibbs JSR, Gor D, Gräf S, Harlow L, Hernandez-Sanchez J, Howard LS, Humbert M, Karnes J, Kiely DG, Kittles R, Knightbridge E, Lam B, Lutz KA, Nichols WC, Pauciulo MW, Pepke-Zaba J, Suntharalingam J, Soubrier F, Trembath RC, Schwantes-An T-HL, Wort SJ, Wilkins M, Gaine S, Morrell NW, Corris PA close, 2021, Mendelian randomisation and experimental medicine approaches to IL-6 as a drug target in PAH, European Respiratory Journal, Vol:59, ISSN:0903-1936, Pages:1-11

Wilkins MR, 2021, Personalized medicine for pulmonary hypertension: the future management of pulmonary hypertension requires a new taxonomy, Clinics in Chest Medicine, Vol:42, ISSN:0272-5231, Pages:207-216

Bai W, Suzuki H, Huang J, et al.Bai W, Suzuki H, Huang J, Francis C, Wang S, Tarroni G, Guitton F, Aung N, Fung K, Petersen SE, Piechnik SK, Neubauer S, Evangelou E, Dehghan A, O'Regan DP, Wilkins MR, Guo Y, Matthews PM, Rueckert D close, 2020, A population-based phenome-wide association study of cardiac and aortic structure and function, Nature Medicine, Vol:26, ISSN:1078-8956, Pages:1654-1662

Rhodes C, Otero-Núñez P, Wharton J, et al.Rhodes C, Otero-Núñez P, Wharton J, Swietlik E, Kariotis S, Harbaum L, Dunning M, Elinoff J, Errington N, Roger T, Iremonger J, Coghlan G, Corris P, Howard L, Kiely D, Church C, Pepke-Zaba J, Toshner M, Stephen W, Desai A, Humbert M, Nichols W, Southgate L, Tregouet D-A, Trembath R, Prokopenko I, Graf S, Morrell N, Wang D, Lawrie A, Wilkins M close, 2020, Whole blood RNA profiles associated with pulmonary arterial hypertension and clinical outcome, American Journal of Respiratory and Critical Care Medicine, Vol:202, ISSN:1073-449X, Pages:586-594

Turro E, Astle WJ, Megy K, et al.Turro E, Astle WJ, Megy K, Graef S, Greene D, Shamardina O, Allen HL, Sanchis-Juan A, Frontini M, Thys C, Stephens J, Mapeta R, Burren OS, Downes K, Haimel M, Tuna S, Deevi SVV, Aitman TJ, Bennett DL, Calleja P, Carss K, Caulfield MJ, Chinnery PF, Dixon PH, Gale DP, James R, Koziell A, Laffan MA, Levine AP, Maher ER, Markus HS, Morales J, Morrell NW, Mumford AD, Ormondroyd E, Rankin S, Rendon A, Richardson S, Roberts I, Roy NBA, Saleem MA, Smith KGC, Stark H, Tan RYY, Themistocleous AC, Thrasher AJ, Watkins H, Webster AR, Wilkins MR, Williamson C, Whitworth J, Humphray S, Bentley DR, Kingston N, Walker N, Bradley JR, Ashford S, Penkett CJ, Freson K, Stirrups KE, Raymond FL, Ouwehand WH close, 2020, Whole-genome sequencing of patients with rare diseases in a national health system, Nature, Vol:583, ISSN:0028-0836, Pages:96-102

Rhodes CJ, Batai K, Bleda M, et al.Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B, Arora A, Knight J, Hanscombe KB, Karnes JH, Kaakinen M, Gall H, Ulrich A, Harbaum L, Cebola I, Ferrer J, Lutz K, Swietlik EM, Ahmad F, Amouyel P, Archer SL, Argula R, Austin ED, Badesch D, Bakshi S, Barnett C, Benza R, Bhatt N, Bogaard HJ, Burger CD, Chakinala M, Church C, Coghlan JG, Condliffe R, Corris PA, Danesino C, Debette S, Elliott CG, Elwing J, Eyries M, Fortin T, Franke A, Frantz RP, Frost A, Garcia JGN, Ghio S, Ghofrani H-A, Gibbs JSR, Harley J, He H, Hill NS, Hirsch R, Houweling AC, Howard LS, Ivy D, Kiely DG, Klinger J, Kovacs G, Lahm T, Laudes M, Machado RD, Ross RVM, Marsolo K, Martin LJ, Moledina S, Montani D, Nathan SD, Newnham M, Olschewski A, Olschewski H, Oudiz RJ, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Rehman Z, Robbins I, Roden DM, Rosenzweig EB, Saydain G, Scelsi L, Schilz R, Seeger W, Shaffer CM, Simms RW, Simon M, Sitbon O, Suntharalingam J, Tang H, Tchourbanov AY, Thenappan T, Torres F, Toshner MR, Treacy CM, Noordegraaf AV, Waisfisz Q, Walsworth AK, Walter RE, Wharton J, White RJ, Wilt J, Wort SJ, Yung D, Lawrie A, Humbert M, Soubrier F, Trégouët D-A, Prokopenko I, Kittles R, Gräf S, Nichols WC, Trembath RC, Desai AA, Morrell NW, Wilkins MR, UK NIHR BioResource Rare Diseases Consortium, UK PAH Cohort Study Consortium, US PAH Biobank Consortium close, 2019, Genetic determinants of risk in pulmonary arterial hypertension: international case-control studies and meta-analysis, Lancet Respiratory Medicine, Vol:7, ISSN:2213-2600, Pages:227-238

Gräf S, Haimel M, Bleda M, et al.Gräf S, Haimel M, Bleda M, Hadinnapola C, Southgate L, Li W, Hodgson J, Liu B, Salmon RM, Southwood M, Machado RD, Martin JM, Treacy CM, Yates K, Daugherty LC, Shamardina O, Whitehorn D, Holden S, Aldred M, Bogaard HJ, Church C, Coghlan G, Condliffe R, Corris PA, Danesino C, Eyries M, Gall H, Ghio S, Ghofrani H-A, Gibbs JSR, Girerd B, Houweling AC, Howard L, Humbert M, Kiely DG, Kovacs G, MacKenzie Ross RV, Moledina S, Montani D, Newnham M, Olschewski A, Olschewski H, Peacock AJ, Pepke-Zaba J, Prokopenko I, Rhodes CJ, Scelsi L, Seeger W, Soubrier F, Stein DF, Suntharalingam J, Swietlik EM, Toshner MR, van Heel DA, Vonk Noordegraaf A, Waisfisz Q, Wharton J, Wort SJ, Ouwehand WH, Soranzo N, Lawrie A, Upton PD, Wilkins MR, Trembath RC, Morrell NW close, 2018, Identification of rare sequence variation underlying heritable pulmonary arterial hypertension, Nature Communications, Vol:9, ISSN:2041-1723, Pages:1-16

Hadinnapola C, Bleda M, Haimel M, et al.Hadinnapola C, Bleda M, Haimel M, Screaton N, Swift AJ, Dorfmüller P, Preston SD, Southwood M, Hernandez-Sanchez J, Martin J, Treacy C, Yates K, Bogaard H, Church C, Coghlan G, Condliffe R, Corris PA, Gibbs SR, Girerd B, Holden S, Humbert M, Kiely DG, Lawrie A, Machado RD, MacKenzie Ross R, Moledina S, Montani D, Newnham M, Peacock AJ, Pepke-Zaba J, Rayner-Matthews PJ, Shamardina O, Soubrier F, Southgate L, Suntharalingam J, Toshner MR, Trembath RC, Vonk Noordegraaf A, Wilkins MR, Wort SJ, Wharton J, Gräf S, Morrell NW, NIHR BioResource - Rare Diseases Consortium & UK National Cohort Study of Idiopathic and Heritable PAH close, 2017, Phenotypic characterisation of EIF2AK4 mutation carriers in a large cohort of patients diagnosed clinically with pulmonary arterial hypertension, Circulation, Vol:136, ISSN:0009-7322, Pages:2022-2033

Michelakis ED, Gurtu V, Webster L, et al.Michelakis ED, Gurtu V, Webster L, Barnes G, Watson G, Howard L, Cupitt J, Paterson I, Thompson RB, Chow K, O'Regan DP, Zhao L, Wharton J, Kiely DG, Kinnaird A, Boukouris AE, White C, Nagendran J, Freed DH, Wort SJ, Gibbs JSR, Wilkins MR close, 2017, Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients, Science Translational Medicine, Vol:9, ISSN:1946-6234, Pages:1-13

Wilkins MR, 2017, Apoptosis signal-regulating kinase 1 inhibition in pulmonary hypertension: too much to ASK?, American Journal of Respiratory and Critical Care Medicine, Vol:197, ISSN:1073-449X, Pages:286-288

Rhodes CJ, Wharton J, Ghataorhe P, et al.Rhodes CJ, Wharton J, Ghataorhe P, Watson G, Girerd B, Howard LS, Gibbs JSR, Condliffe R, Elliot CA, Kiely DG, Simonneau G, Montani D, Sitbon O, Gall H, Schermuly RT, Ghofrani HA, Lawrie A, Humbert M, Wilkins MR close, 2017, Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study, Lancet Respiratory Medicine, Vol:5, ISSN:2213-2600, Pages:717-726

Rhodes CJ, Ghataorhe P, Wharton J, et al.Rhodes CJ, Ghataorhe P, Wharton J, Rue-Albrecht KC, Hadinnapola C, Watson G, Bleda M, Haimel M, Coghlan G, Corris PA, Howard LS, Kiely DG, Peacock AJ, Pepke-Zaba J, Toshner MR, Wort SJ, Gibbs SR, Lawrie A, Graf S, Morrell NW, Wilkins MR close, 2017, Plasma metabolomics implicate modified transfer RNAs and altered bioenergetics in the outcome of pulmonary arterial hypertension, Circulation, Vol:135, ISSN:0009-7322, Pages:460-475

Zhao L, Oliver E, Maratou K, et al.Zhao L, Oliver E, Maratou K, Atanur SS, Dubois OD, Cotroneo E, Chen CN, Wang L, Arce C, Chabosseau PL, Ponsa-Cobas J, Frid MG, Moyon B, Webster Z, Aldashev A, Ferrer J, Rutter GA, Stenmark KR, Aitman TJ, Wilkins MR close, 2015, The zinc transporter, ZIP12, regulates the pulmonary vascular response to chronic hypoxia, Nature, Vol:524, ISSN:0028-0836, Pages:356-360

Wilkins MR, Ghofrani H-A, Weissmann N, et al.Wilkins MR, Ghofrani H-A, Weissmann N, Aldashev A, Zhao L close, 2015, Pathophysiology and Treatment of High-Altitude Pulmonary Vascular Disease, Circulation, Vol:131, ISSN:0009-7322, Pages:582-590

Wilkins MR, Aldashev AA, Wharton J, et al.Wilkins MR, Aldashev AA, Wharton J, Rhodes CJ, Vandrovcova J, Kasperaviciute D, Bhosle SG, Mueller M, Geschka S, Rison S, Kojonazarov B, Morrell NW, Neidhardt I, Surmeli NB, Aitman TJ, Stasch J-P, Behrends S, Marletta MA close, 2014, α1-A680T Variant in GUCY1A3 as a Candidate Conferring Protection From Pulmonary Hypertension Among Kyrgyz Highlanders, Circulation-Cardiovascular Genetics, Vol:7, ISSN:1942-325X, Pages:920-U505

Wojciak-Stothard B, Abdul-Salam VB, Lao KH, et al.Wojciak-Stothard B, Abdul-Salam VB, Lao KH, Tsang H, Irwin DC, Lisk C, Loomis Z, Stenmark KR, Edwards JC, Yuspa SH, Howard LS, Edwards RJ, Rhodes CJ, Gibbs JSR, Wharton J, Zhao L, Wilkins MR close, 2014, Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension, Circulation, Vol:129, ISSN:0009-7322, Pages:1770-1780

Ghofrani HA, D'Armini AM, Grimminger F, et al.Ghofrani HA, D'Armini AM, Grimminger F, Hoeper MM, Jansa P, Kim NH, Mayer E, Simonneau G, Wilkins MR, Fritsch A, Neuser D, Weimann G, Wang C; CHEST-1 Study Group. close, 2013, Riociguat for the treatment of chronic thromboembolic pulmonary hypertension., New England Journal of Medicine

Open Access Link

Zhao L, Ashek A, Wang L, et al.Zhao L, Ashek A, Wang L, Fang W, Dabral S, Dubois O, Cupitt J, Pullamsetti SS, Cotroneo E, Jones H, Tomasi G, Nguyen GD, Aboagye EO, El-Bahrawy MA, Barnes G, Howard LS, Gibbs SR, Gsell W, He JG, and Wilkins MR close, 2013, Heterogeneity in lung 18FDG uptake in PAH: potential of dynamic 18FDG-PET with kinetic analysis as a bridging biomarker for pulmonary remodeling targeted treatments, Circulation

Rhodes CJ, Wharton J, Boon RA, et al.Rhodes CJ, Wharton J, Boon RA, Roexe T, Tsang H, Wojciak-Stothard B, Chakrabarti A, Howard LS, Gibbs JS, Lawrie A, Condliffe R, Elliot CA, Kiely DG, Huson L, Ghofrani HA, Tiede H, Schermuly R, Zeiher AM, Dimmeler S, Wilkins MR close, 2013, Reduced microRNA-150 is associated with poor survival in pulmonary arterial hypertension., American Journal of Respiratory and Critical Care Medicine, Vol:187, Pages:294-302

Zhao L, Chen C-N, Hajji N, et al.Zhao L, Chen C-N, Hajji N, Oliver E, Cotroneo E, Wharton J, Wang D, Li M, McKinsey TA, Stenmark KR, Wilkins MR close, 2012, Histone Deacetylation Inhibition in Pulmonary Hypertension Therapeutic Potential of Valproic Acid and Suberoylanilide Hydroxamic Acid, Circulation, Vol:126, ISSN:0009-7322, Pages:455-+

Wojciak-Stothard B, Zhao L, Oliver E, et al.Wojciak-Stothard B, Zhao L, Oliver E, Dubois O, Wu Y, Kardassis D, Vasilaki E, Huang M, Mitchell JA, Louise H, Prendergast GC, Wilkins MR close, 2012, Role of RhoB in the Regulation of Pulmonary Endothelial and Smooth Muscle Cell Responses to Hypoxia, Circulation Research, Vol:110, ISSN:0009-7330, Pages:1423-+

Rhodes CJ, Wharton J, Howard L, et al.Rhodes CJ, Wharton J, Howard L, Gibbs JSR, Vonk-Noordegraaf A, Wilkins MR close, 2011, Iron deficiency in pulmonary arterial hypertension: a potential therapeutic target, European Respiratory Journal, Vol:38, ISSN:0903-1936, Pages:1453-1460

Schermuly RT, Ghofrani HA, Wilkins MR, et al.Schermuly RT, Ghofrani HA, Wilkins MR, Grimminger F close, 2011, Mechanisms of disease: pulmonary arterial hypertension, Nature Reviews Cardiology, Vol:8, ISSN:1759-5002, Pages:443-455

Rhodes CJ, Howard LS, Busbridge M, et al.Rhodes CJ, Howard LS, Busbridge M, Ashby D, Kondili E, Gibbs JSR, Wharton J, Wilkins MR close, 2011, Iron Deficiency and Raised Hepcidin in Idiopathic Pulmonary Arterial Hypertension Clinical Prevalence, Outcomes, and Mechanistic Insights, Journal of the American College of Cardiology, Vol:58, ISSN:0735-1097, Pages:300-309

Rhodes CJ, Wharton J, Howard LS, et al.Rhodes CJ, Wharton J, Howard LS, Gibbs JSR, Wilkins MR close, 2011, Red cell distribution width outperforms other potential circulating biomarkers in predicting survival in idiopathic pulmonary arterial hypertension, Heart, Vol:97, ISSN:1355-6037, Pages:1054-1060

Abdul-Salam VB, Wharton J, Cupitt J, et al.Abdul-Salam VB, Wharton J, Cupitt J, Berryman M, Edwards RJ, Wilkins MR close, 2010, Proteomic Analysis of Lung Tissues From Patients With Pulmonary Arterial Hypertension, Circulation, Vol:122, ISSN:0009-7322, Pages:2058-U282

Wilkins MR, Ali O, Bradlow W, et al.Wilkins MR, Ali O, Bradlow W, Wharton J, Taegtmeyer A, Rhodes CJ, Ghofrani HA, Howard L, Nihoyannopoulos P, Mohiaddin RH, Gibbs JSR close, 2010, Simvastatin as a Treatment for Pulmonary Hypertension Trial, American Journal of Respiratory and Critical Care Medicine, Vol:181, ISSN:1073-449X, Pages:1106-1113

Archer SL, Weir EK, Wilkins MR, 2010, Basic Science of Pulmonary Arterial Hypertension for Clinicians New Concepts and Experimental Therapies, Circulation, Vol:121, ISSN:0009-7322, Pages:2045-U175

Michelakis ED, Wilkins MR, Rabinovitch M, 2008, Emerging concepts and translational priorities in pulmonary arterial hypertension, Circulation, Vol:118, ISSN:0009-7322, Pages:1486-1495

Nickel N, Kempf T, Tapken H, et al.Nickel N, Kempf T, Tapken H, Tongers J, Laenger F, Lehmann U, Golpon H, Olsson K, Wilkins MR, Gibbs JSR, Hoeper MM, Wollert KC close, 2008, Growth differentiation factor-15 in idiopathic pulmonary arterial hypertension, American Journal of Respiratory and Critical Care Medicine, Vol:178, ISSN:1073-449X, Pages:534-541

Wilkins MR, Wharton J, Grimminger F, et al.Wilkins MR, Wharton J, Grimminger F, Ghofrani HA close, 2008, Phosphodiesterase inhibitors for the treatment of pulmonary hypertension, European Respiratory Journal, Vol:32, ISSN:0903-1936, Pages:198-209

Aldashev AA, Kojonazarov BK, Amatov TA, et al.Aldashev AA, Kojonazarov BK, Amatov TA, Sooronbaev TM, Mirrakhimov MM, Morrell NW, Wharton J, Wilkins MR close, 2005, Phosphodiesterase type 5 and high altitude pulmonary hypertension, Thorax, Vol:60, ISSN:0040-6376, Pages:683-687

Wharton J, Strange JW, Moller GMO, et al.Wharton J, Strange JW, Moller GMO, Growcott EJ, Ren XH, Franklyn AP, Phillips SC, Wilkins MR close, 2005, Antiproliferative effects of phosphodiesterase type 5 inhibition in human pulmonary artery cells, American Journal of Respiratory and Critical Care Medicine, Vol:172, ISSN:1073-449X, Pages:105-113

Paul GA, Gibbs JSR, Boobis AR, et al.Paul GA, Gibbs JSR, Boobis AR, Abbas A, Wilkins MR close, 2005, Bosentan decreases the plasma concentration of sildenafil when coprescribed in pulmonary hypertension, British Journal of Clinical Pharmacology, Vol:60, ISSN:0306-5251, Pages:107-112

Wilkins MR, Paul GA, Strange JW, et al.Wilkins MR, Paul GA, Strange JW, Tunariu N, Gin-Sing W, Banya WA, Westwood MA, Stefanidis A, Ng LL, Pennell DJ, Mohiaddin RH, Nihoyannopoulos P, Gibbs JSR close, 2005, Sildenafil versus endothelin receptor antagonist for pulmonary hypertension (SERAPH) study, American Journal of Respiratory and Critical Care Medicine, Vol:171, ISSN:1073-449X, Pages:1292-1297

Khoo JP, Zhao L, Alp NJ, et al.Khoo JP, Zhao L, Alp NJ, Bendall JK, Nicoli T, Rockett K, Wilkins MR, Channon KM close, 2005, Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension, Circulation, Vol:111, ISSN:0009-7322, Pages:2126-2133

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