Publications
241 results found
Rhodes CJ, Wharton J, Howard L, et al., 2011, Iron deficiency in pulmonary arterial hypertension: a potential therapeutic target, EUROPEAN RESPIRATORY JOURNAL, Vol: 38, Pages: 1453-1460, ISSN: 0903-1936
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- Citations: 75
Nasim MT, Ogo T, Ahmed M, et al., 2011, Molecular genetic characterization of SMAD signaling molecules in pulmonary arterial hypertension, HUMAN MUTATION, Vol: 32, Pages: 1385-1389, ISSN: 1059-7794
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- Citations: 119
Zhai Z, Murphy K, Tighe H, et al., 2011, Differences in Ventilatory Inefficiency Between Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension, CHEST, Vol: 140, Pages: 1284-1291, ISSN: 0012-3692
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- Citations: 75
Schermuly RT, Ghofrani HA, Wilkins MR, et al., 2011, Mechanisms of disease: pulmonary arterial hypertension, Nature Reviews Cardiology, Vol: 8, Pages: 443-455, ISSN: 1759-5002
Our understanding of, and approach to, pulmonary arterial hypertension has undergone a paradigm shift in the past decade. Once a condition thought to be dominated by increased vasoconstrictor tone and thrombosis, pulmonary arterial hypertension is now seen as a vasculopathy in which structural changes driven by excessive vascular cell growth and inflammation, with recruitment and infiltration of circulating cells, play a major role. Perturbations of a number of molecular mechanisms have been described, including pathways involving growth factors, cytokines, metabolic signaling, elastases, and proteases, that may underlie the pathogenesis of the disease. Elucidating their contribution to the pathophysiology of pulmonary arterial hypertension could offer new drug targets. The role of progenitor cells in vascular repair is also under active investigation. The right ventricular response to increased pressure load is recognized as critical to survival and the molecular mechanisms involved are attracting increasing interest. The challenge now is to integrate this new knowledge and explore how it can be used to categorize patients by molecular phenotype and tailor treatment more effectively.
Rhodes CJ, Howard LS, Busbridge M, et al., 2011, Iron Deficiency and Raised Hepcidin in Idiopathic Pulmonary Arterial Hypertension Clinical Prevalence, Outcomes, and Mechanistic Insights, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 58, Pages: 300-309, ISSN: 0735-1097
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- Citations: 181
Rhodes CJ, Wharton J, Howard LS, et al., 2011, Red cell distribution width outperforms other potential circulating biomarkers in predicting survival in idiopathic pulmonary arterial hypertension, HEART, Vol: 97, Pages: 1054-1060, ISSN: 1355-6037
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- Citations: 145
Zhao L, Zhai Z, Wharton J, et al., 2011, Phosphodiesterase inhibitors in the treatment of pulmonary hypertension, Textbook of pulmonary vascular disease, Editors: Yuan, Garcia, Hales, Rich, Archer, West, Publisher: Springer, Pages: 1477-1486
Abdul-Salam VB, Wharton J, Cupitt J, et al., 2010, Proteomic Analysis of Lung Tissues From Patients With Pulmonary Arterial Hypertension, CIRCULATION, Vol: 122, Pages: 2058-U282, ISSN: 0009-7322
Wilkins MR, Ali O, Bradlow W, et al., 2010, Simvastatin as a Treatment for Pulmonary Hypertension Trial, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 181, Pages: 1106-1113, ISSN: 1073-449X
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- Citations: 99
Archer SL, Weir EK, Wilkins MR, 2010, Basic Science of Pulmonary Arterial Hypertension for Clinicians New Concepts and Experimental Therapies, CIRCULATION, Vol: 121, Pages: 2045-U175, ISSN: 0009-7322
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- Citations: 382
Wilkins MR, Wharton J, Zhao L, 2010, What animal models tell us about treatments of pulmonary hypertension, Pulmonary arterial hypertension, Editors: Antel, Hesselink, Schermuly, Pages: 57-69
Zhao L, Sebkhi A, Ali O, et al., 2009, Simvastatin and sildenafil combine to attenuate pulmonary hypertension, EUROPEAN RESPIRATORY JOURNAL, Vol: 34, Pages: 948-957, ISSN: 0903-1936
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- Citations: 43
Rhodes CJ, Davidson A, Gibbs JSR, et al., 2009, Therapeutic targets in pulmonary arterial hypertension, PHARMACOLOGY & THERAPEUTICS, Vol: 121, Pages: 69-88, ISSN: 0163-7258
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- Citations: 71
Baliga RS, Zhao L, Madhani M, et al., 2008, Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 178, Pages: 861-869, ISSN: 1073-449X
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- Citations: 48
Michelakis ED, Wilkins MR, Rabinovitch M, 2008, Emerging concepts and translational priorities in pulmonary arterial hypertension, CIRCULATION, Vol: 118, Pages: 1486-1495, ISSN: 0009-7322
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- Citations: 114
Nickel N, Kempf T, Tapken H, et al., 2008, Growth differentiation factor-15 in idiopathic pulmonary arterial hypertension, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 178, Pages: 534-541, ISSN: 1073-449X
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- Citations: 111
Wilkins MR, Wharton J, Grimminger F, et al., 2008, Phosphodiesterase inhibitors for the treatment of pulmonary hypertension, EUROPEAN RESPIRATORY JOURNAL, Vol: 32, Pages: 198-209, ISSN: 0903-1936
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- Citations: 119
Diller G-P, van Eijl S, Okonko DO, et al., 2008, Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension, CIRCULATION, Vol: 117, Pages: 3020-3030, ISSN: 0009-7322
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- Citations: 171
Gibbs JSR, 2008, Consensus statement on the management of pulmonary hypertension in clinical practice in the UK and Ireland, HEART, Vol: 94, ISSN: 1355-6037
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- Citations: 7
Bogle R, Wilkins M, 2007, Treating acute myocardial infarction: something in the wind?, LANCET, Vol: 370, Pages: 1461-1462, ISSN: 0140-6736
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- Citations: 2
Ali O, Wharton J, Simon J, et al., 2007, Emerging therapies for pulmonary arterial hypertension, EXPERT OPINION ON INVESTIGATIONAL DRUGS, Vol: 16, Pages: 803-818, ISSN: 1354-3784
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- Citations: 12
Kojonazarov BK, Imanov BZ, Amatov TA, et al., 2007, Noninvasive and invasive evaluation of pulmonary arterial pressure in highlanders, EUROPEAN RESPIRATORY JOURNAL, Vol: 29, Pages: 352-356, ISSN: 0903-1936
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- Citations: 24
Zhao L, Bahaa F, Wilkins M, 2007, Tetrarydrobiopterin and pulmonary hypertension, PROBLEMS OF HIGH ALTITUDE MEDICINE AND BIOLOGY, Pages: 69-+, ISSN: 1874-6489
Machado RD, Koehler R, Glissmeyer E, et al., 2006, Genetic association of the serotonin transporter in pulmonary arterial hypertension, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 173, Pages: 793-797, ISSN: 1073-449X
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- Citations: 65
Abdul-Salam VB, Paul GA, Ali JO, et al., 2006, Identification of plasma protein biomarkers associated with idiopathic pulmonary arterial hypertension, PROTEOMICS, Vol: 6, Pages: 2286-2294, ISSN: 1615-9853
Aldashev AA, Kojonazarov BK, Amatov TA, et al., 2005, Phosphodiesterase type 5 and high altitude pulmonary hypertension, THORAX, Vol: 60, Pages: 683-687, ISSN: 0040-6376
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- Citations: 74
Wharton J, Strange JW, Moller GMO, et al., 2005, Antiproliferative effects of phosphodiesterase type 5 inhibition in human pulmonary artery cells, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 172, Pages: 105-113, ISSN: 1073-449X
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- Citations: 272
Paul GA, Gibbs JSR, Boobis AR, et al., 2005, Bosentan decreases the plasma concentration of sildenafil when coprescribed in pulmonary hypertension, BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 60, Pages: 107-112, ISSN: 0306-5251
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- Citations: 174
Wilkins MR, Paul GA, Strange JW, et al., 2005, Sildenafil versus endothelin receptor antagonist for pulmonary hypertension (SERAPH) study, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 171, Pages: 1292-1297, ISSN: 1073-449X
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- Citations: 288
Khoo JP, Zhao L, Alp NJ, et al., 2005, Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension, CIRCULATION, Vol: 111, Pages: 2126-2133, ISSN: 0009-7322
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- Citations: 122
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