Imperial College London
Portrait Picture

Professor Martin Wilkins

Faculty of Medicine, National Heart & Lung Institute

Professor of Clinical Pharmacology
 
 
 
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Contact

 

+44 (0)20 3313 6101m.wilkins Website

 
 
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Assistant

 

Mrs Elizabeth O'Brien +44 (0)20 3313 6101

 
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Location

 

NIHR Imperial Clinical Research FacilityICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Shah:2023:10.1038/s41467-023-40566-6,
author = {Shah, M and Inacio, M and Lu, C and Schiratti, P-R and Zheng, S and Clement, A and Simoes, Monteiro de Marvao A and Bai, W and King, A and Ware, J and Wilkins, M and Mielke, J and Elci, E and Kryukov, I and McGurk, K and Bender, C and Freitag, D and O'Regan, D},
doi = {10.1038/s41467-023-40566-6},
journal = {Nature Communications},
pages = {1--15},
title = {Environmental and genetic predictors of human cardiovascular ageing},
url = {http://dx.doi.org/10.1038/s41467-023-40566-6},
volume = {14},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cardiovascular ageing is a process that begins early in life and leads to a progressive change instructure and decline in function due to accumulated damage across diverse cell types, tissues andorgans contributing to multi-morbidity. Damaging biophysical, metabolic and immunological factors exceed endogenous repair mechanisms resulting in a pro-fibrotic state, cellular senescence andend-organ damage, however the genetic architecture of cardiovascular ageing is not known. Herewe use machine learning approaches to quantify cardiovascular age from image-derived traits ofvascular function, cardiac motion and myocardial fibrosis, as well as conduction traits from electrocardiograms, in 39,559 participants of UK Biobank. Cardiovascular ageing is found to be significantly associated with common or rare variants in genes regulating sarcomere homeostasis, myocardial immunomodulation, and tissue responses to biophysical stress. Ageing is accelerated bycardiometabolic risk factors and we also identify prescribed medications that are potential modifiersof ageing. Through large-scale modelling of ageing across multiple traits our results reveal insightsinto the mechanisms driving premature cardiovascular ageing and reveal potential molecular targetsto attenuate age-related processes.
AU  - Shah,M
AU  - Inacio,M
AU  - Lu,C
AU  - Schiratti,P-R
AU  - Zheng,S
AU  - Clement,A
AU  - Simoes,Monteiro de Marvao A
AU  - Bai,W
AU  - King,A
AU  - Ware,J
AU  - Wilkins,M
AU  - Mielke,J
AU  - Elci,E
AU  - Kryukov,I
AU  - McGurk,K
AU  - Bender,C
AU  - Freitag,D
AU  - O'Regan,D
DO  - 10.1038/s41467-023-40566-6
EP  - 15
PY  - 2023///
SN  - 2041-1723
SP  - 1
TI  - Environmental and genetic predictors of human cardiovascular ageing
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-023-40566-6
UR  - https://www.nature.com/articles/s41467-023-40566-6
UR  - http://hdl.handle.net/10044/1/105738
VL  - 14
ER  -
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