Imperial College London
Portrait Picture

Professor Martin Wilkins

Faculty of Medicine, National Heart & Lung Institute

Professor of Clinical Pharmacology
 
 
 
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Contact

 

+44 (0)20 3313 6101m.wilkins Website

 
 
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Assistant

 

Mrs Elizabeth O'Brien +44 (0)20 3313 6101

 
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Location

 

NIHR Imperial Clinical Research FacilityICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Brash:2018:10.1016/j.jacbts.2018.01.013,
author = {Brash, L and Barnes, GD and Brewis, MJ and Church, AC and Gibbs, SJ and Howard, LSGE and Jayasekera, G and Johnson, MK and McGlinchey, N and Onorato, J and Simpson, J and Stirrat, C and Thomson, S and Watson, G and Wilkins, MR and Xu, C and Welsh, DJ and Newby, DE and Peacock, AJ},
doi = {10.1016/j.jacbts.2018.01.013},
journal = {JACC: Basic to Translational Science},
pages = {176--186},
title = {Short-term hemodynamic effects of apelin in patients with pulmonary arterial hypertension},
url = {http://dx.doi.org/10.1016/j.jacbts.2018.01.013},
volume = {3},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Apelin agonism causes systemic vasodilatation and increased cardiac contractility in humans, and improves pulmonary arterial hypertension (PAH) in animal models. Here, the authors examined the short-term pulmonary hemodynamic effects of systemic apelin infusion in patients with PAH. In a double-blind randomized crossover study, 19 patients with PAH received intravenous (Pyr 1 )apelin-13 and matched saline placebo during invasive right heart catheterization. (Pyr 1 )apelin-13 infusion caused a reduction in pulmonary vascular resistance and increased cardiac output. This effect was accentuated in the subgroup of patients receiving concomitant phosphodiesterase type 5 inhibition. Apelin agonism is a novel potential therapeutic target for PAH. (Effects of Apelin on the Lung Circulation in Pulmonary Hypertension; NCT01457170)
AU  - Brash,L
AU  - Barnes,GD
AU  - Brewis,MJ
AU  - Church,AC
AU  - Gibbs,SJ
AU  - Howard,LSGE
AU  - Jayasekera,G
AU  - Johnson,MK
AU  - McGlinchey,N
AU  - Onorato,J
AU  - Simpson,J
AU  - Stirrat,C
AU  - Thomson,S
AU  - Watson,G
AU  - Wilkins,MR
AU  - Xu,C
AU  - Welsh,DJ
AU  - Newby,DE
AU  - Peacock,AJ
DO  - 10.1016/j.jacbts.2018.01.013
EP  - 186
PY  - 2018///
SN  - 2452-302X
SP  - 176
TI  - Short-term hemodynamic effects of apelin in patients with pulmonary arterial hypertension
T2  - JACC: Basic to Translational Science
UR  - http://dx.doi.org/10.1016/j.jacbts.2018.01.013
UR  - http://hdl.handle.net/10044/1/58195
VL  - 3
ER  -
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