Publications
183 results found
Stovell MG, Ruetten PPR, Tozer DJ, et al., 2024, Characterizing diffusion from microdialysis catheters in the human brain: a magnetic resonance imaging study with gadobutrol., J Neurotrauma
Cerebral microdialysis (CMD) catheters allow continuous monitoring of patients' cerebral metabolism in severe traumatic brain injury (TBI). The catheters consist of a terminal semi-permeable membrane that is inserted into the brain's interstitium to allow perfusion fluid to equalize with the surrounding cerebral extracellular environment before being recovered through a central non-porous channel. However, it is unclear how far recovered fluid and suspended metabolites have diffused from within the brain, and therefore what volume or region of brain tissue the analyses of metabolism represent. We assessed diffusion of the small magnetic resonance (MR)-detectible molecule gadobutrol from microdialysis catheters in six subjects (complete data five subjects, incomplete data one subject) who had sustained a severe TBI. Diffusion pattern and distance in cerebral white matter were assessed using T1 (time for MR spin-lattice relaxation) maps at 1 mm isotropic resolution in a 3 Tesla MR scanner. Gadobutrol at 10 mmol/L diffused from cerebral microdialysis catheters in a uniform spheroidal (ellipsoid of revolution) pattern around the catheters' semipermeable membranes, and across grey matter-white matter boundaries. Evidence of gadobutrol diffusion was found up to a mean of 13.4 ± 0.5 mm (mean ± s.d.) from catheters, but with a steep concentration drop off so that ≤ 50 % of maximum concentration was achieved at ≈ 4 mm, and ≤ 10 % of maximum was found beyond ≈ 7 mm from the catheters. There was little variation between subjects. The relaxivity of gadobutrol in human cerebral white matter was estimated to be 1.61 ± 0.38 L.mmol-1s-1 (mean ± s.d.); assuming gadobutrol remained extracellular thereby occupying 20 % of total tissue volume (interstitium), and concentration equilibrium with perfusion fluid was achieved immediately adjacent to catheters after 24 hours of perfusion. No statistically significant change was found in the conce
Williams IJM, Navaratnam AV, Wilson M, et al., 2023, Endoscopic Endonasal Repair and Reconstruction of Traumatic Anterior Skull Base Defects, CASE REPORTS IN OTOLARYNGOLOGY, Vol: 2023, ISSN: 2090-6765
Wilson MH, Ashworth E, Hutchinson PJ, 2022, A proposed novel traumatic brain injury classification system - an overview and inter-rater reliability validation on behalf of the Society of British Neurological Surgeons, BRITISH JOURNAL OF NEUROSURGERY, Vol: 36, Pages: 633-638, ISSN: 0268-8697
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- Citations: 2
Arkell P, Wilson R, Antcliffe DB, et al., 2022, A pilot observational study of CSF vancomycin therapeutic drug monitoring during the treatment of nosocomial ventriculitis., Journal of Infection, ISSN: 0163-4453
Graham NSN, Zimmerman KA, Moro F, et al., 2021, Axonal marker neurofilament light predicts long-term outcomes and progressive neurodegeneration after traumatic brain injury, Science Translational Medicine, Vol: 13, Pages: 1-15, ISSN: 1946-6234
Axonal injury is a key determinant of long-term outcomes after traumatic brain injury (TBI) but has been difficult to measure clinically. Fluid biomarker assays can now sensitively quantify neuronal proteins in blood. Axonal components such as neurofilament light (NfL) potentially provide a diagnostic measure of injury. In the multicenter BIO-AX-TBI study of moderate-severe TBI, we investigated relationships between fluid biomarkers, advanced neuroimaging, and clinical outcomes. Cerebral microdialysis was used to assess biomarker concentrations in brain extracellular fluid aligned with plasma measurement. An experimental injury model was used to validate biomarkers against histopathology. Plasma NfL increased after TBI, peaking at 10 days to 6 weeks but remaining abnormal at 1 year. Concentrations were around 10 times higher early after TBI than in controls (patients with extracranial injuries). NfL concentrations correlated with diffusion MRI measures of axonal injury and predicted white matter neurodegeneration. Plasma TAU predicted early gray matter atrophy. NfL was the strongest predictor of functional outcomes at 1 year. Cerebral microdialysis showed that NfL concentrations in plasma and brain extracellular fluid were highly correlated. An experimental injury model confirmed a dose-response relationship of histopathologically defined axonal injury to plasma NfL. In conclusion, plasma NfL provides a sensitive and clinically meaningful measure of axonal injury produced by TBI. This reflects the extent of underlying damage, validated using advanced MRI, cerebral microdialysis, and an experimental model. The results support the incorporation of NfL sampling subacutely after injury into clinical practice to assist with the diagnosis of axonal injury and to improve prognostication.
Mahmood A, Needham K, Shakur-Still H, et al., 2021, Effect of tranexamic acid on intracranial haemorrhage and infarction in patients with traumatic brain injury: a pre-planned substudy in a sample of CRASH-3 trial patients, EMERGENCY MEDICINE JOURNAL, Vol: 38, Pages: 270-278, ISSN: 1472-0205
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- Citations: 7
Mahmood A, Needham K, Shakur-Still H, et al., 2021, Tranexamic acid in traumatic brain injury: an explanatory study nested within the CRASH-3 trial, EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY, Vol: 47, Pages: 261-268, ISSN: 1863-9933
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- Citations: 11
Calzolari E, Chepisheva M, Smith RM, et al., 2021, Vestibular agnosia in traumatic brain injury and its link to imbalance, Brain, Vol: 144, Pages: 128-143, ISSN: 0006-8950
Vestibular dysfunction, causing dizziness and imbalance, is a common yet poorly understoodfeature in traumatic brain injury patients. Damage to the inner ear, nerve, brainstem, cerebellumand cerebral hemispheres may all affect vestibular functioning, hence, a multi-level assessment– from reflex to perception – is required. In a previous report, postural instability was thecommonest neurological feature in ambulating acute traumatic brain injury patients. We alsofrequently observe, during ward assessment of acute traumatic brain injury patients withcommon inner ear conditions and a related vigorous vestibular-ocular reflex nystagmus, a lossof vertigo sensation, suggesting a “vestibular agnosia”. Vestibular agnosia patients were alsomore unbalanced, however the link between vestibular agnosia and imbalance was confoundedby the presence of inner ear conditions. We investigated the brain mechanisms of imbalance inacute traumatic brain injury, its link with vestibular agnosia, and potential clinical impact, byprospective laboratory assessment of vestibular function, from reflex to perception, in patientswith preserved peripheral vestibular function. Assessment included vestibular-reflex function;vestibular-perception by participants’ report of their passive yaw rotations in the dark;objective balance via posturography; subjective symptoms via questionnaires; and structuralneuroimaging. We prospectively screened 918 acute admissions, assessed 146 and recruited37. Compared to 37 matched controls, patients showed elevated vestibular-perceptualthresholds (patients 12.92°/s vs. 3.87°/s) but normal vestibular-ocular reflex thresholds(patients 2.52°/s vs. 1.78°/s). Patients with elevated vestibular-perceptual thresholds (3standard deviations above controls’ average), were designated as having vestibular agnosia,and displayed worse posturography than non-vestibular-agnosia patients, despite no differencein vestibular symptom sc
Dixon L, 2020, Cerebral microhaemorrhage in COVID-19: A critical illness related phenomenon?, Stroke and Vascular Neurology, Vol: 5, Pages: 315-322, ISSN: 2059-8696
BackgroundCerebral microhaemorrhages are increasingly being recognised as a complication of COVID-19. This observational retrospective study aims to further investigate the potential pathophysiology through assessing the pattern of microhaemorrhage and clinical characteristics of patients with COVID-19 and microhaemorrhage. By comparing to similar patterns of microhaemorrhage in other non-COVID-19 disease this study aims to propose possible common pathogenic mechanisms. MethodsA retrospective observational case series was performed identifying all patients with COVID-19 complicated by cerebral microhaemorrhage on MRI. The distribution and number of microhaemorrhages were recorded using the microbleed anatomical scale (MARS) and patients baseline characteristics and salient test results were also recorded. ResultsCerebral microhaemorrhages were noted to have a predilection for the corpus callosum, the juxtacortical white matter and brainstem. All patients had a preceding period of critical illness with respiratory failure and severe hypoxia necessitating intubation and mechanical ventilation. DiscussionThis study demonstrates a pattern of cerebral microhaemorrhage which is similar to the pattern reported in patients with non-COVID-19 related critical illness and other causes of severe hypoxia. This raises questions regarding whether microhaemorrhage occurs from endothelial dysfunction due the direct effect of SARS-CoV-2 infection or from the secondary effects of critical illness and hypoxia.
Kolias AG, Horner D, Menon DK, et al., 2020, Tranexamic acid for traumatic brain injury, LANCET, Vol: 396, Pages: 163-164, ISSN: 0140-6736
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- Citations: 1
McBride R, Ski CF, Thompson DR, et al., 2020, Championing survival: connecting the unknown network of responders to address out-of-hospital cardiac arrest, SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE, Vol: 28, ISSN: 1757-7241
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- Citations: 3
Harris L, Hateley S, Tsang KT, et al., 2020, Impact of anti-epileptic drug choice on discharge in acute traumatic brain injury patients, Journal of Neurology, Vol: 267, Pages: 1774-1779, ISSN: 0340-5354
BackgroundAnti-epileptic drug (AED) prophylaxis in the first-seven days post-traumatic brain injury (TBI) is known to reduce seizure frequency acutely. AED efficacy is equivalent; therefore, choice of AED may rest with their side-effects. We hypothesise that AEDs that impair balance will prolong recovery, shown by a longer hospital stay. We compared length of hospital stay (and reported dizziness) in TBI patients receiving the commonest AEDs used in our TBI patients, Phenytoin (which may cause imbalance), and Levetiracetam (which does not affect balance).MethodA retrospective observational study was performed on TBI patients admitted to a Major Trauma Unit between October 2013 and June 2018. 100 of 278 patients treated with phenytoin or levetiracetam monotherapy for seizure prophylaxis were included. The inclusion criteria of admission Glasgow Coma Score of 14 or more and length of stay less than 3 weeks minimised confounding variables such as non-ambulant patients. Length of hospital stay and incidence of dizziness were assessed.ResultsThe length of hospital stay was longer for patients on Phenytoin versus Levetiracetam, i.e., 10.74 vs. 7.58 days (p = 0.015; unpaired, two-sided t test). Dizziness reported by patients on phenytoin was 24% and levetiracetam was 8% (p = 0.018; Chi-squared test).ConclusionIn this cohort, using Phenytoin for acute TBI, seizure prophylaxis was associated with longer length of stay and more dizziness compared to Levetiracetam. Given their equivalent AED efficacy in acute TBI seizure prophylaxis, our data suggest that Levetiracetam is preferable to Phenytoin for early seizure prophylaxis in TBI. This requires evaluation in larger, prospective studies.
Dekker MCJ, Wilson MH, Howlett WP, 2019, Mountain neurology, PRACTICAL NEUROLOGY, Vol: 19, Pages: 404-411, ISSN: 1474-7758
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- Citations: 3
Kontojannis V, Hostettler I, Brogan RJ, et al., 2019, Detection of intracranial hematomas in the emergency department using near infrared spectroscopy., Brain Inj, Vol: 33, Pages: 875-883
Hypothesis: Traumatic brain injury (TBI) is one of the most important causes of morbidity and mortality in our society. The development of near infrared technology for the detection of intracranial hematomas may assist earlier diagnosis of TBI. This in turn may enable earlier targeted treatments minimizing the harm and subsequent social and economic effects of TBI. Methods: A handheld, noninvasive Near Infrared Spectroscopy device, Infrascanner 2000, (Infrascan Inc., Philadelphia, PA, USA) was used in a major trauma center to screen for traumatic intracranial hematomas. The Infrascanner was used successfully in 205 patients on their arrival in the emergency department prior to CT head. Results: In the whole cohort, sensitivity was 75%, specificity was 50.43%, with negative predictive value 72.84%, and positive predictive value 53.23%. In 45 patients, where the volume of blood was >3.5mL, the sensitivity was 89.36%, specificity 48.73% with negative predictive value 93.9% and positive predictive value 34.15%. Conclusions: The Infrascanner has a relatively high specificity and negative predictive value; therefore, it could in association with the Neurological examination, help in the triage of the trauma patient with potential brain injury. Further investigation is necessary to determine the use of Infrascanner 2000 as a diagnostic method in TBI.
Marcus HJ, Paine H, Sargeant M, et al., 2019, Vestibular dysfunction in acute traumatic brain injury, Journal of Neurology, Vol: 266, Pages: 2430-2433, ISSN: 0340-5354
Traumatic brain injury (TBI) is the commonest cause of disability in under-40-year-olds. Vestibular features of dizziness (illusory self-motion) or imbalance which affects 50% of TBI patients at 5 years, increases unemployment threefold in TBI survivors. Unfortunately, vestibular diagnoses are cryptogenic in 25% of chronic TBI cases, impeding therapy. We hypothesized that chronic adaptive brain mechanisms uncouple vestibular symptoms from signs. This predicts a masking of vestibular diagnoses chronically but not acutely. Hence, defining the spectrum of vestibular diagnoses in acute TBI should clarify vestibular diagnoses in chronic TBI. There are, however, no relevant acute TBI data. Of 111 Major Trauma Ward adult admissions screened (median 38-years-old), 96 patients (87%) had subjective dizziness (illusory self-motion) and/or objective imbalance were referred to the senior author (BMS). Symptoms included: feeling unbalanced (58%), headache (50%) and dizziness (40%). In the 47 cases assessed by BMS, gait ataxia was the commonest sign (62%) with half of these cases denying imbalance when asked. Diagnoses included BPPV (38%), acute peripheral unilateral vestibular loss (19%), and migraine phenotype headache (34%), another potential source of vestibular symptoms. In acute TBI, vestibular signs are common, with gait ataxia being the most frequent one. However, patients underreport symptoms. The uncoupling of symptoms from signs likely arises from TBI affecting perceptual mechanisms. Hence, the cryptogenic nature of vestibular symptoms in TBI (acute or chronic) relates to a complex interaction between injury (to peripheral and central vestibular structures and perceptual mechanisms) and brain-adaptation, emphasizing the need for acute prospective, mechanistic studies.
Christopher E, Poon MTC, Glancz LJ, et al., 2019, Outcomes following surgery in subgroups of comatose and very elderly patients with chronic subdural hematoma, NEUROSURGICAL REVIEW, Vol: 42, Pages: 427-431, ISSN: 0344-5607
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- Citations: 23
ter Avest E, Lambert E, de Coverly R, et al., 2019, Live video footage from scene to aid helicopter emergency medical service dispatch: a feasibility study, SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE, Vol: 27, ISSN: 1757-7241
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- Citations: 22
Hostettler IC, Murahari S, Raza MH, et al., 2018, Case report on the spontaneous resolution of a traumatic intracranial acute subdural haematoma: evaluation of the guidelines, ACTA NEUROCHIRURGICA, Vol: 160, Pages: 1311-1314, ISSN: 0001-6268
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- Citations: 1
Smith CM, Wilson MH, Perkins GD, 2018, Reply to: Letter by Derkenne et al. regarding the article, 'The use of trained volunteers in the response to out-of-hospital cardiac arrest - The GoodSAM experience.', RESUSCITATION, Vol: 125, Pages: E4-E4, ISSN: 0300-9572
Wilson MH, Hargens AR, Imray CH, 2018, Effects of Spaceflight on Astronaut Brain Structure, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 378, Pages: 581-581, ISSN: 0028-4793
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- Citations: 4
Harvey D, Butler J, Groves J, et al., 2018, Management of perceived devastating brain injury after hospital admission: a consensus statement from stakeholder professional organizations, BRITISH JOURNAL OF ANAESTHESIA, Vol: 120, Pages: 138-145, ISSN: 0007-0912
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- Citations: 53
Smith CM, Wilson MH, Ghorbangholi A, et al., 2017, The use of trained volunteers in the response to out-of-hospital cardiac arrest - the GoodSAM experience, RESUSCITATION, Vol: 121, Pages: 123-126, ISSN: 0300-9572
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- Citations: 73
Veljanoski D, Grier G, Wilson MH, 2017, Counting the Cost of Cervical Collars, PREHOSPITAL AND DISASTER MEDICINE, Vol: 32, Pages: 701-702, ISSN: 1049-023X
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- Citations: 1
Smith CM, Keung SNLC, Khan MO, et al., 2017, Barriers and facilitators to public access defibrillation in out-of-hospital cardiac arrest: a systematic review, EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES, Vol: 3, Pages: 264-273, ISSN: 2058-5225
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- Citations: 62
Wilson MH, Forbes AE, Schutzer-Weissmann J, et al., 2017, Head injury patterns in helmeted and non-helmeted cyclists admitted to a London Major Trauma Centre with serious head injury., PLoS ONE, Vol: 12, ISSN: 1932-6203
BackgroundCycle use across London and the UK has increased considerably over the last 10 years. With this there has been an increased interest in cycle safety and injury prevention. Head injuries are an important cause of mortality and morbidity in cyclists. This study aimed to ascertain the frequency of different head injury types in cyclists and whether wearing a bicycle helmet affords protection against specific types of head injury.MethodsA retrospective observational study of all cyclists older than 16 years admitted to a London Major Trauma Centre between 1st January 2011 and 31st December 2015 was completed. A cohort of patients who had serious head injury was identified (n = 129). Of these, data on helmet use was available for 97. Comparison was made between type of injury frequency in helmeted and non-helmeted cyclists within this group of patients who suffered serious head injury.ResultsHelmet use was shown to be protective against intracranial injury in general (OR 0.2, CI 0.07–0.55, p = 0.002). A protective effect against subdural haematoma was demonstrated (OR 0.14, CI 0.03–0.72, p = 0.02). Wearing a helmet was also protective against skull fractures (OR 0.12, CI 0.04–0.39, p<0.0001) but not any other specific extracranial injuries. This suggests that bicycle helmets are protective against those injuries caused by direct impact to the head. Further research is required to clarify their role against injuries caused by shearing forces.ConclusionsIn a largely urban environment, the use of cycle helmets appears to be protective for certain types of serious intra and extracranial head injuries. This may help to inform future helmet design.
Griva K, Stygall J, Wilson MH, et al., 2017, Caudwell Xtreme Everest: A prospective study of the effects of environmental hypoxia on cognitive functioning, PLOS ONE, Vol: 12, ISSN: 1932-6203
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- Citations: 22
Hutchinson PJ, Kolias AG, Timofeev IS, et al., 2017, Trial of decompressive craniectomy for traumatic intracranial hypertension, Journal of Neurosurgical Anesthesiology, Vol: 29, Pages: 175-176, ISSN: 0898-4921
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- Citations: 2
Wilson M, 2017, GoodSAM - how digital networks can revolutionise care in life-threatening emergencies, PERSPECTIVES IN PUBLIC HEALTH, Vol: 137, Pages: 23-24, ISSN: 1757-9139
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- Citations: 4
Brogan RJ, Kontojannis V, Garara B, et al., 2017, Near-infrared spectroscopy (NIRS) to detect traumatic intracranial haematoma: A systematic review and meta-analysis, BRAIN INJURY, Vol: 31, Pages: 581-588, ISSN: 0269-9052
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- Citations: 22
Wilson MH, 2016, Traumatic brain injury: an underappreciated public health issue, LANCET PUBLIC HEALTH, Vol: 1, Pages: E44-E44, ISSN: 2468-2667
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- Citations: 15
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