Imperial College London

Professor SirMagdiYacoub

Faculty of MedicineNational Heart & Lung Institute

Professor of Cardiothoracic Surgery
 
 
 
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Contact

 

+44 (0)1895 828 893m.yacoub

 
 
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Location

 

Heart Science Centre, HarefieldHarefield HospitalHarefield Hospital

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Summary

 

Publications

Publication Type
Year
to

1456 results found

Dokainish H, Teo K, Zhu J, Roy A, AlHabib KF, ElSayed A, Palileo-Villaneuva L, Lopez-Jaramillo P, Karaye K, Yusoff K, Orlandini A, Sliwa K, Mondo C, Lanas F, Prabhakaran D, Badr A, Elmaghawry M, Damasceno A, Tibazarwa K, Belley-Cote E, Balasubramanian K, Islam S, Yacoub MH, Huffman MD, Harkness K, Grinvalds A, McKelvie R, Bangdiwala SI, Yusuf Set al., 2017, Global mortality variations in patients with heart failure: results from the International Congestive Heart Failure (INTER-CHF) prospective cohort study, LANCET GLOBAL HEALTH, Vol: 5, Pages: E665-E672, ISSN: 2214-109X

JOURNAL ARTICLE

El-Sherbiny I, Khalil I, Ali I, Yacoub Met al., 2017, Updates on smart polymeric carrier systems for protein delivery, DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, Vol: 43, Pages: 1567-1583, ISSN: 0363-9045

JOURNAL ARTICLE

El-Sherbiny IM, Elbaz NM, Sedki M, Elgammal A, Yacoub MHet al., 2017, Magnetic nanoparticles-based drug and gene delivery systems for the treatment of pulmonary diseases, NANOMEDICINE, Vol: 12, Pages: 387-402, ISSN: 1743-5889

JOURNAL ARTICLE

Gemechu T, Mahmoud H, Parry EHO, Phillips DIW, Yacoub MHet al., 2017, Community-based prevalence study of rheumatic heart disease in rural Ethiopia, EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, Vol: 24, Pages: 717-723, ISSN: 2047-4873

JOURNAL ARTICLE

Hassan M, Wagdy K, Kharabish A, Selwanos PP, Nabil A, Elguindy A, ElFaramawy A, Elmahdy MF, Mahmoud H, Yacoub MHet al., 2017, Validation of Noninvasive Measurement of Cardiac Output Using Inert Gas Rebreathing in a Cohort of Patients With Heart Failure and Reduced Ejection Fraction, CIRCULATION-HEART FAILURE, Vol: 10, ISSN: 1941-3289

JOURNAL ARTICLE

Jakovljevic DG, Yacoub MH, Schueler S, MacGowan GA, Velicki L, Seferovic PM, Hothi S, Tzeng B-H, Brodie DA, Birks E, Tan L-Bet al., 2017, Left Ventricular Assist Device as a Bridge to Recovery for Patients With Advanced Heart Failure, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 69, Pages: 1924-1933, ISSN: 0735-1097

JOURNAL ARTICLE

Krishnamoorthy N, Tseng Y-T, Gajendrarao P, Sarathchandra P, McCormack A, Carubelli I, Sohier J, Latif N, Chester AH, Yacoub MHet al., 2017, A Strategy to Enhance Secretion of Extracellular Matrix Components by Stem Cells: Relevance to Tissue Engineering., Tissue Eng Part A

The ability of cells to secrete extracellular matrix proteins is an important property in the repair, replacement, and regeneration of living tissue. Cells that populate tissue-engineered constructs need to be able to emulate these functions. The motifs, KTTKS or palmitoyl-KTTKS (peptide amphiphile), have been shown to stimulate production of collagen and fibronectin in differentiated cells. Molecular modeling was used to design different forms of active peptide motifs to enhance the efficacy of peptides to increase collagen and fibronectin production using terminals KTTKS/SKTTK/SKTTKS connected by various hydrophobic linkers, V4A3/V4A2/A4G3. Molecular dynamic simulations showed SKTTKS-V4A3-SKTTKS (P3), with palindromic (SKTTKS) motifs and SKTTK-V4A2-KTTKS (P5), maintained structural integrity and favorable surface electrostatic distributions that are required for functionality. In vitro studies showed that peptides, P3 and P5, showed low toxicity to human adipose-derived stem cells (hADSCs) and significantly increased the production of collagen and fibronectin in a concentration-dependent manner compared with the original active peptide motif. The 4-day treatment showed that stem cell markers of hADSCs remained stable with P3. The molecular design of novel peptides is a promising strategy for the development of intelligent biomaterials to guide stem cell function for tissue engineering applications.

JOURNAL ARTICLE

Mohamed NA, Davies RP, Lickiss PD, Ahmetaj-Shala B, Reed DM, Gashaw HH, Saleem H, Freeman GR, George PM, Wort SJ, Morales-Cano D, Barreira B, Tetley TD, Chester AH, Yacoub MH, Kirkby NS, Moreno L, Mitchell JAet al., 2017, Chemical and biological assessment of metal organic frameworks (MOFs) in pulmonary cells and in an acute in vivo model: relevance to pulmonary arterial hypertension therapy, PULMONARY CIRCULATION, Vol: 7, Pages: 643-653, ISSN: 2045-8932

JOURNAL ARTICLE

Porras AM, van Engeland NCA, Marchbanks E, McCormack A, Bouten CVC, Yacoub MH, Latif N, Masters KSet al., 2017, Robust Generation of Quiescent Porcine Valvular Interstitial Cell Cultures, JOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol: 6, ISSN: 2047-9980

JOURNAL ARTICLE

Salhiyyah K, Sarathchandra P, Latif N, Yacoub MH, Chester AHet al., 2017, Hypoxia-mediated regulation of the secretory properties of mitral valve interstitial cells, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 313, Pages: H14-H23, ISSN: 0363-6135

JOURNAL ARTICLE

Soliman AB, Haikal RR, Abugable AA, Hassan MH, Karakalos SG, Pellechia PJ, Hassan HH, Yacoub MH, Alkordi MHet al., 2017, Tailoring the Oxygen Reduction Activity of Hemoglobin through Immobilization within Microporous Organic Polymer-Graphene Composite, ACS APPLIED MATERIALS & INTERFACES, Vol: 9, Pages: 27918-27926, ISSN: 1944-8244

JOURNAL ARTICLE

Yacoub MH, 2017, RESPONSE: Trainees in Regional Centers of Excellence in the Developing World A Win-Win for Global Cardiology, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 69, Pages: 2463-2464, ISSN: 0735-1097

JOURNAL ARTICLE

Yacoub MH, Afifi A, Saad H, Aguib H, ElGuindy Aet al., 2017, Current state of the art and future of myectomy, ANNALS OF CARDIOTHORACIC SURGERY, Vol: 6, Pages: 307-317, ISSN: 2225-319X

JOURNAL ARTICLE

van Engeland NCA, Bertazzo S, Sarathchandra P, McCormack A, Bouten CVC, Yacoub MH, Chester AH, Latif Net al., 2017, Aortic calcified particles modulate valvular endothelial and interstitial cells, CARDIOVASCULAR PATHOLOGY, Vol: 28, Pages: 36-45, ISSN: 1054-8807

JOURNAL ARTICLE

Dokainish H, Teo K, Zhu J, Roy A, AlHabib KF, ElSayed A, Palileo-Villaneuva L, Lopez-Jaramillo P, Karaye K, Yusoff K, Orlandini A, Sliwa K, Mondo C, Lanas F, Prabhakaran D, Badr A, Elmaghawry M, Damasceno A, Tibazarwa K, Belley-Cote E, Balasubramanian K, Yacoub MH, Huffman MD, Harkness K, Grinvalds A, McKelvie R, Yusuf Set al., 2016, Heart Failure in Africa, Asia, the Middle East and South America: The INTER-CHF study, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 204, Pages: 133-141, ISSN: 0167-5273

JOURNAL ARTICLE

El-Hamamsy I, Yacoub MH, 2016, Towards More Personalized Surgical Indications for Thoracic Aortic Dilatation: Are We There Yet?, CANADIAN JOURNAL OF CARDIOLOGY, Vol: 32, Pages: 4-7, ISSN: 0828-282X

JOURNAL ARTICLE

Kaniewska-Bednarczuk E, Mielcarek M, Chester AH, Slominska EM, Yacoub MH, Smolenski RTet al., 2016, Oxidized low-density lipoproteins enhance expression and activity of CD39 and CD73 in the human aortic valve endothelium, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, Vol: 35, Pages: 713-719, ISSN: 1525-7770

JOURNAL ARTICLE

Kutryb-Zajac B, Yuen AHY, Khalpey Z, Zukowska P, Slominska EM, Taylor PM, Goldstein S, Heacox AE, Lavitrano M, Chester AH, Yacoub MH, Smolenski RTet al., 2016, Nucleotide Catabolism on the Surface of Aortic Valve Xenografts; Effects of Different Decellularization Strategies, JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 9, Pages: 119-126, ISSN: 1937-5387

JOURNAL ARTICLE

Lee S-L, Aguib H, Chapron J, Bahmanyar R, Borghi A, Murphy O, McLeod C, ElGuindy A, Yacoub Met al., 2016, Spatial Orientation and Morphology of the Pulmonary Artery: Relevance to Optimising Design and Positioning of a Continuous Pressure Monitoring Device, JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 9, Pages: 239-248, ISSN: 1937-5387

JOURNAL ARTICLE

Mohamed NA, Ahmetaj-Shala B, Duluc L, Mackenzie LS, Kirkby NS, Reed DM, Lickiss PD, Davies RP, Freeman GR, Wojciak-Stothard B, Chester AH, El-Sherbiny IM, Mitchell JA, Yacoub MHet al., 2016, A New NO-Releasing Nanoformulation for the Treatment of Pulmonary Arterial Hypertension, JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 9, Pages: 162-164, ISSN: 1937-5387

JOURNAL ARTICLE

Mongkoldhumrongkul N, Latif N, Yacoub MH, Chester AHet al., 2016, Effect of Side-Specific Valvular Shear Stress on the Content of Extracellular Matrix in Aortic Valves., Cardiovasc Eng Technol

Responses of valve endothelial cells (VECs) to shear stresses are important for the regulation of valve durability. However, the effect of flow patterns subjected to VECs on the opposite surfaces of the valves on the production of extracellular matrix (ECM) has not yet been investigated. This study aims to investigate the response of side-specific flow patterns, in terms of ECM synthesis and/or degradation in porcine aortic valves. Aortic and ventricular sides of aortic valve leaflets were exposed to oscillatory and laminar flow generated by a Cone-and-Plate machine for 48 h. The amount of collagen, GAGs and elastin was quantified and compared to samples collected from the same leaflets without exposing to flow. The results demonstrated that flow is important to maintain the amount of GAGs and elastin in the valve, as compared to the effect of static conditions. Particularly, the laminar waveform plays a crucial role on the modulation of elastin in side-independent manner. Furthermore, the ability of oscillatory flow on the aortic surface to increase the amount of collagen and GAGs cannot be replicated by exposure of an identical flow pattern on the ventricular side of the valve. Side-specific responses to the particular patterns of flow are important to the regulation of ECM components. Such understanding is imperative to the creation of tissue-engineered heart valves that must be created from the "appropriate" cells that can replicate the functions of the native VECs to regulate the different constituents of ECM.

JOURNAL ARTICLE

Mongkoldhumrongkul N, Yacoub MH, Chester AH, 2016, Valve Endothelial Cells - Not Just Any Old Endothelial Cells, CURRENT VASCULAR PHARMACOLOGY, Vol: 14, Pages: 146-154, ISSN: 1570-1611

JOURNAL ARTICLE

Torii R, Parker KH, Yacoub MH, 2016, Importance of Stress Mapping of Aortic Wall in Aortic Valve Disease, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 67, Pages: 1755-1756, ISSN: 0735-1097

JOURNAL ARTICLE

Allouba MH, ElGuindy AM, Krishnamoorthy N, Yacoub MH, Aguib YEet al., 2015, NaNog: A pluripotency homeobox (master) molecule., Glob Cardiol Sci Pract, Vol: 2015, ISSN: 2305-7823

One of the most intriguing aspects of cell biology is the state of pluripotency, where the cell is capable of self-renewal for as many times as deemed "necessary", then at a specified time can differentiate into any type of cell. This fundamental process is required during organogenesis in foetal life and importantly during tissue repair in health and disease. Pluripotency is very tightly regulated, as any dysregulation can result in congenital defects, inability to repair damage, or cancer. Fuelled by the relatively recent interest in stem cell biology and tissue regeneration, the molecules implicated in regulating pluripotency have been the subject of extensive research. One of the important molecules involved in pluripotency, is NaNog, the subject of this article.

JOURNAL ARTICLE

Backhaus J, Yacoub L, Kambaris A, Wright G, Yacoub MHet al., 2015, The Burundi Heart Centre: From concept to design., Glob Cardiol Sci Pract, Vol: 2015, ISSN: 2305-7823

Burundi is one of the world's poorest nations, which is also reflected in its relative lack of cardiac facilities, particularly those catering to young children and adults. The authors discuss current efforts to build "The Burundi Heart Centre" to help address this challenge. In particular, they highlight how the project can act as a case study for a sustainable architecture that involves local people and uses locally available materials in a contemporary and innovative way.

JOURNAL ARTICLE

Balbaa A, ElGuindy A, Pericak D, Yacoub MH, Schwalm JDet al., 2015, An evaluation of secondary prophylaxis for rheumatic heart disease in rural Egypt., Glob Cardiol Sci Pract, Vol: 2015, ISSN: 2305-7823

BACKGROUND: Although essentially disappeared from the industrialized world, rheumatic heart disease (RHD) is still prevalent in developing countries, with 300,000 new cases identified each year. In Aswan, Egypt, RHD affects about 2.3% of children with over 90% of the cases being subclinical. Secondary prophylaxis has proved to be an effective method of preventing the progression of RHD. However, its efficacy is limited by low patient adherence. A systematic, generalizable tool is necessary to outline, and ultimately address these barriers. METHODS: A 43-item semi-structured questionnaire was developed based on the three domains outlined by Fishbein (capability, intention, and health care barriers). A preliminary evaluation of the barriers to RHD prophylaxis use in Aswan, Egypt was carried out as a pilot study using this tool. Participants were local school children diagnosed with RHD or flagged as high-risk (as per a set of echocardiographic criteria developed by the Aswan Heart Centre) through a previous screening program of randomly selected 3,062 school children in Aswan. RESULTS: 29 patients were interviewed (65.5% adherent to RHD prophylaxis). Compared to non-adherent patients, adherent patients had better understanding of the disease (68.4% versus 20% in the non-adherent group, p = 0.021), and were more aware of the consequences of missing prophylaxis doses (79% versus 40% of non-adherent patients, p = 0.005). Furthermore, 90% of non-adherent patients consciously choose to miss injection appointments (as compared to 31.6% of adherent patients, p = 0.005). Clinic wait time was the most frequently reported deterrent for both groups. CONCLUSION: A standardized tool that systematically outlines barriers to prophylaxis is a necessary first step to improving adherence to penicillin. Although individually developed tools exist for specific populations, a generalizable tool that takes into account the demographic and cultural differences

JOURNAL ARTICLE

Cartledge JE, Kane C, Dias P, Tesfom M, Clarke L, Mckee B, Al Ayoubi S, Chester A, Yacoub MH, Camelliti P, Terracciano CMet al., 2015, Functional crosstalk between cardiac fibroblasts and adult cardiomyocytes by soluble mediators, CARDIOVASCULAR RESEARCH, Vol: 105, Pages: 260-270, ISSN: 0008-6363

JOURNAL ARTICLE

El-Sherbiny IM, El-Baz NM, Yacoub MH, 2015, Inhaled nano- and microparticles for drug delivery., Glob Cardiol Sci Pract, Vol: 2015, ISSN: 2305-7823

The 21st century has seen a paradigm shift to inhaled therapy, for both systemic and local drug delivery, due to the lung's favourable properties of a large surface area and high permeability. Pulmonary drug delivery possesses many advantages, including non-invasive route of administration, low metabolic activity, control environment for systemic absorption and avoids first bypass metabolism. However, because the lung is one of the major ports of entry, it has multiple clearance mechanisms, which prevent foreign particles from entering the body. Although these clearance mechanisms maintain the sterility of the lung, clearance mechanisms can also act as barriers to the therapeutic effectiveness of inhaled drugs. This effectiveness is also influenced by the deposition site and delivered dose. Particulate-based drug delivery systems have emerged as an innovative and promising alternative to conventional inhaled drugs to circumvent pulmonary clearance mechanisms and provide enhanced therapeutic efficiency and controlled drug release. The principle of multiple pulmonary clearance mechanisms is reviewed, including mucociliary, alveolar macrophages, absorptive, and metabolic degradation. This review also discusses the current approaches and formulations developed to achieve optimal pulmonary drug delivery systems.

JOURNAL ARTICLE

Ibrahim M, Nader A, Yacoub MH, Terracciano Cet al., 2015, Manipulation of sarcoplasmic reticulum Ca2+ release in heart failure through mechanical intervention, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 593, Pages: 3253-3259, ISSN: 0022-3751

JOURNAL ARTICLE

Jacob SS, Hassan M, Yacoub MH, 2015, Utility of mass spectrometry for the diagnosis of the unstable coronary plaque., Glob Cardiol Sci Pract, Vol: 2015, ISSN: 2305-7823

Mass spectrometry is a powerful technique that is used to identify unknown compounds, to quantify known materials, and to elucidate the structure and chemical properties of molecules. Recent advances in the accuracy and speed of the technology have allowed data acquisition for the global analysis of lipids from complex samples such as blood plasma or serum. Here, mass spectrometry as a tool is described, its limitations explained and its application to biomarker discovery in coronary artery disease is considered. In particular an application of mass spectrometry for the discovery of lipid biomarkers that may indicate plaque morphology that could lead to myocardial infarction is elucidated.

JOURNAL ARTICLE

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