1459 results found
Dokainish H, Teo K, Zhu J, et al., 2017, Global mortality variations in patients with heart failure: results from the International Congestive Heart Failure (INTER-CHF) prospective cohort study, LANCET GLOBAL HEALTH, Vol: 5, Pages: E665-E672, ISSN: 2214-109X
El-Sherbiny I, Khalil I, Ali I, et al., 2017, Updates on smart polymeric carrier systems for protein delivery, DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, Vol: 43, Pages: 1567-1583, ISSN: 0363-9045
El-Sherbiny IM, Elbaz NM, Sedki M, et al., 2017, Magnetic nanoparticles-based drug and gene delivery systems for the treatment of pulmonary diseases, NANOMEDICINE, Vol: 12, Pages: 387-402, ISSN: 1743-5889
Gemechu T, Mahmoud H, Parry EHO, et al., 2017, Community-based prevalence study of rheumatic heart disease in rural Ethiopia, EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, Vol: 24, Pages: 717-723, ISSN: 2047-4873
Hassan M, Wagdy K, Kharabish A, et al., 2017, Validation of Noninvasive Measurement of Cardiac Output Using Inert Gas Rebreathing in a Cohort of Patients With Heart Failure and Reduced Ejection Fraction, CIRCULATION-HEART FAILURE, Vol: 10, ISSN: 1941-3289
Jakovljevic DG, Yacoub MH, Schueler S, et al., 2017, Left Ventricular Assist Device as a Bridge to Recovery for Patients With Advanced Heart Failure, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 69, Pages: 1924-1933, ISSN: 0735-1097
Krishnamoorthy N, Tseng Y-T, Gajendrarao P, et al., 2017, A Strategy to Enhance Secretion of Extracellular Matrix Components by Stem Cells: Relevance to Tissue Engineering., Tissue Eng Part A
The ability of cells to secrete extracellular matrix proteins is an important property in the repair, replacement, and regeneration of living tissue. Cells that populate tissue-engineered constructs need to be able to emulate these functions. The motifs, KTTKS or palmitoyl-KTTKS (peptide amphiphile), have been shown to stimulate production of collagen and fibronectin in differentiated cells. Molecular modeling was used to design different forms of active peptide motifs to enhance the efficacy of peptides to increase collagen and fibronectin production using terminals KTTKS/SKTTK/SKTTKS connected by various hydrophobic linkers, V4A3/V4A2/A4G3. Molecular dynamic simulations showed SKTTKS-V4A3-SKTTKS (P3), with palindromic (SKTTKS) motifs and SKTTK-V4A2-KTTKS (P5), maintained structural integrity and favorable surface electrostatic distributions that are required for functionality. In vitro studies showed that peptides, P3 and P5, showed low toxicity to human adipose-derived stem cells (hADSCs) and significantly increased the production of collagen and fibronectin in a concentration-dependent manner compared with the original active peptide motif. The 4-day treatment showed that stem cell markers of hADSCs remained stable with P3. The molecular design of novel peptides is a promising strategy for the development of intelligent biomaterials to guide stem cell function for tissue engineering applications.
Mohamed NA, Davies RP, Lickiss PD, et al., 2017, Chemical and biological assessment of metal organic frameworks (MOFs) in pulmonary cells and in an acute in vivo model: relevance to pulmonary arterial hypertension therapy, PULMONARY CIRCULATION, Vol: 7, Pages: 643-653, ISSN: 2045-8932
Porras AM, van Engeland NCA, Marchbanks E, et al., 2017, Robust Generation of Quiescent Porcine Valvular Interstitial Cell Cultures, JOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol: 6, ISSN: 2047-9980
Salhiyyah K, Sarathchandra P, Latif N, et al., 2017, Hypoxia-mediated regulation of the secretory properties of mitral valve interstitial cells, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 313, Pages: H14-H23, ISSN: 0363-6135
Soliman AB, Haikal RR, Abugable AA, et al., 2017, Tailoring the Oxygen Reduction Activity of Hemoglobin through Immobilization within Microporous Organic Polymer-Graphene Composite, ACS APPLIED MATERIALS & INTERFACES, Vol: 9, Pages: 27918-27926, ISSN: 1944-8244
Yacoub MH, 2017, RESPONSE: Trainees in Regional Centers of Excellence in the Developing World A Win-Win for Global Cardiology, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 69, Pages: 2463-2464, ISSN: 0735-1097
van Engeland NCA, Bertazzo S, Sarathchandra P, et al., 2017, Aortic calcified particles modulate valvular endothelial and interstitial cells, CARDIOVASCULAR PATHOLOGY, Vol: 28, Pages: 36-45, ISSN: 1054-8807
Danial JSH, Aguib Y, Yacoub MH, 2016, Advanced fluorescence microscopy techniques for the life sciences., Glob Cardiol Sci Pract, Vol: 2016, ISSN: 2305-7823
The development of super-resolved fluorescence microscopy, for which the Nobel Prize was awarded in 2014, has been a topic of interest to physicists and biologists alike. It is inevitable that numerous questions in biomedical research cannot be answered by means other than direct observation. In this review, advances to fluorescence microscopy are covered in a widely accessible fashion to facilitate its use in decisions related to its acquisition and utilization in biomedical research.
Dokainish H, Teo K, Zhu J, et al., 2016, Heart Failure in Africa, Asia, the Middle East and South America: The INTER-CHF study, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 204, Pages: 133-141, ISSN: 0167-5273
El-Hamamsy I, Yacoub MH, 2016, Towards More Personalized Surgical Indications for Thoracic Aortic Dilatation: Are We There Yet?, CANADIAN JOURNAL OF CARDIOLOGY, Vol: 32, Pages: 4-7, ISSN: 0828-282X
Kaniewska-Bednarczuk E, Mielcarek M, Chester AH, et al., 2016, Oxidized low-density lipoproteins enhance expression and activity of CD39 and CD73 in the human aortic valve endothelium, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, Vol: 35, Pages: 713-719, ISSN: 1525-7770
Kutryb-Zajac B, Yuen AHY, Khalpey Z, et al., 2016, Nucleotide Catabolism on the Surface of Aortic Valve Xenografts; Effects of Different Decellularization Strategies, JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 9, Pages: 119-126, ISSN: 1937-5387
Lee S-L, Aguib H, Chapron J, et al., 2016, Spatial Orientation and Morphology of the Pulmonary Artery: Relevance to Optimising Design and Positioning of a Continuous Pressure Monitoring Device, JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 9, Pages: 239-248, ISSN: 1937-5387
Mohamed NA, Ahmetaj-Shala B, Duluc L, et al., 2016, A New NO-Releasing Nanoformulation for the Treatment of Pulmonary Arterial Hypertension, JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 9, Pages: 162-164, ISSN: 1937-5387
Mongkoldhumrongkul N, Latif N, Yacoub MH, et al., 2016, Effect of Side-Specific Valvular Shear Stress on the Content of Extracellular Matrix in Aortic Valves., Cardiovasc Eng Technol
Responses of valve endothelial cells (VECs) to shear stresses are important for the regulation of valve durability. However, the effect of flow patterns subjected to VECs on the opposite surfaces of the valves on the production of extracellular matrix (ECM) has not yet been investigated. This study aims to investigate the response of side-specific flow patterns, in terms of ECM synthesis and/or degradation in porcine aortic valves. Aortic and ventricular sides of aortic valve leaflets were exposed to oscillatory and laminar flow generated by a Cone-and-Plate machine for 48 h. The amount of collagen, GAGs and elastin was quantified and compared to samples collected from the same leaflets without exposing to flow. The results demonstrated that flow is important to maintain the amount of GAGs and elastin in the valve, as compared to the effect of static conditions. Particularly, the laminar waveform plays a crucial role on the modulation of elastin in side-independent manner. Furthermore, the ability of oscillatory flow on the aortic surface to increase the amount of collagen and GAGs cannot be replicated by exposure of an identical flow pattern on the ventricular side of the valve. Side-specific responses to the particular patterns of flow are important to the regulation of ECM components. Such understanding is imperative to the creation of tissue-engineered heart valves that must be created from the "appropriate" cells that can replicate the functions of the native VECs to regulate the different constituents of ECM.
Mongkoldhumrongkul N, Yacoub MH, Chester AH, 2016, Valve Endothelial Cells - Not Just Any Old Endothelial Cells, CURRENT VASCULAR PHARMACOLOGY, Vol: 14, Pages: 146-154, ISSN: 1570-1611
Spadotto V, Voges I, Kilner PJ, et al., 2016, Juxtaposition of the atrial appendages: A nidus for thrombus in atriopulmonary Fontan?, Glob Cardiol Sci Pract, Vol: 2016, ISSN: 2305-7823
Juxtaposition of atrial appendages is a rare cardiac congenital anomaly, usually associated with other cardiac malformations. Until now, it has not been linked to any significant clinical implications. We report cardiovascular magnetic resonance (CMR) findings of two adult patients who underwent atriopulmonary Fontan operation in the setting of left juxtaposition of the atrial appendages. The patients were in sinus rhythm at the time of the CMR study. Both patients had episodes of sustained atrial tachyarrhythmia requiring electrical cardioversion and were anticoagulated with warfarin with target INR 2-3. CMR images showed a thrombus located in the enlarged and juxtaposed right appendage in both patients. Blood flow frequently appears slow or sluggish in the dilated right atrium following atriopulmonary Fontan surgery. In addition, cine CMR suggested that blood flow reaches very low velocities in the massively dilated juxtaposed right atrial appendage cul-de-sac, thus potentially creating a substrate for clot formation. These findings propose that juxtaposed atrial appendages in atriopulmonary Fontan is an additional risk factor for clot formation, specifically in the dilated right atrial appendage on the left side juxtaposed with the left atrial appendage and that prophylactic anticoagulation is highly justified in these patients.
Torii R, Parker KH, Yacoub MH, 2016, Importance of Stress Mapping of Aortic Wall in Aortic Valve Disease, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 67, Pages: 1755-1756, ISSN: 0735-1097
One of the most intriguing aspects of cell biology is the state of pluripotency, where the cell is capable of self-renewal for as many times as deemed "necessary", then at a specified time can differentiate into any type of cell. This fundamental process is required during organogenesis in foetal life and importantly during tissue repair in health and disease. Pluripotency is very tightly regulated, as any dysregulation can result in congenital defects, inability to repair damage, or cancer. Fuelled by the relatively recent interest in stem cell biology and tissue regeneration, the molecules implicated in regulating pluripotency have been the subject of extensive research. One of the important molecules involved in pluripotency, is NaNog, the subject of this article.
Burundi is one of the world's poorest nations, which is also reflected in its relative lack of cardiac facilities, particularly those catering to young children and adults. The authors discuss current efforts to build "The Burundi Heart Centre" to help address this challenge. In particular, they highlight how the project can act as a case study for a sustainable architecture that involves local people and uses locally available materials in a contemporary and innovative way.
Balbaa A, ElGuindy A, Pericak D, et al., 2015, An evaluation of secondary prophylaxis for rheumatic heart disease in rural Egypt., Glob Cardiol Sci Pract, Vol: 2015, ISSN: 2305-7823
BACKGROUND: Although essentially disappeared from the industrialized world, rheumatic heart disease (RHD) is still prevalent in developing countries, with 300,000 new cases identified each year. In Aswan, Egypt, RHD affects about 2.3% of children with over 90% of the cases being subclinical. Secondary prophylaxis has proved to be an effective method of preventing the progression of RHD. However, its efficacy is limited by low patient adherence. A systematic, generalizable tool is necessary to outline, and ultimately address these barriers. METHODS: A 43-item semi-structured questionnaire was developed based on the three domains outlined by Fishbein (capability, intention, and health care barriers). A preliminary evaluation of the barriers to RHD prophylaxis use in Aswan, Egypt was carried out as a pilot study using this tool. Participants were local school children diagnosed with RHD or flagged as high-risk (as per a set of echocardiographic criteria developed by the Aswan Heart Centre) through a previous screening program of randomly selected 3,062 school children in Aswan. RESULTS: 29 patients were interviewed (65.5% adherent to RHD prophylaxis). Compared to non-adherent patients, adherent patients had better understanding of the disease (68.4% versus 20% in the non-adherent group, p = 0.021), and were more aware of the consequences of missing prophylaxis doses (79% versus 40% of non-adherent patients, p = 0.005). Furthermore, 90% of non-adherent patients consciously choose to miss injection appointments (as compared to 31.6% of adherent patients, p = 0.005). Clinic wait time was the most frequently reported deterrent for both groups. CONCLUSION: A standardized tool that systematically outlines barriers to prophylaxis is a necessary first step to improving adherence to penicillin. Although individually developed tools exist for specific populations, a generalizable tool that takes into account the demographic and cultural differences
Cartledge JE, Kane C, Dias P, et al., 2015, Functional crosstalk between cardiac fibroblasts and adult cardiomyocytes by soluble mediators, CARDIOVASCULAR RESEARCH, Vol: 105, Pages: 260-270, ISSN: 0008-6363
El-Sherbiny IM, El-Baz NM, Yacoub MH, 2015, Inhaled nano- and microparticles for drug delivery., Glob Cardiol Sci Pract, Vol: 2015, ISSN: 2305-7823
The 21st century has seen a paradigm shift to inhaled therapy, for both systemic and local drug delivery, due to the lung's favourable properties of a large surface area and high permeability. Pulmonary drug delivery possesses many advantages, including non-invasive route of administration, low metabolic activity, control environment for systemic absorption and avoids first bypass metabolism. However, because the lung is one of the major ports of entry, it has multiple clearance mechanisms, which prevent foreign particles from entering the body. Although these clearance mechanisms maintain the sterility of the lung, clearance mechanisms can also act as barriers to the therapeutic effectiveness of inhaled drugs. This effectiveness is also influenced by the deposition site and delivered dose. Particulate-based drug delivery systems have emerged as an innovative and promising alternative to conventional inhaled drugs to circumvent pulmonary clearance mechanisms and provide enhanced therapeutic efficiency and controlled drug release. The principle of multiple pulmonary clearance mechanisms is reviewed, including mucociliary, alveolar macrophages, absorptive, and metabolic degradation. This review also discusses the current approaches and formulations developed to achieve optimal pulmonary drug delivery systems.
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