Imperial College London

Professor SirMagdiYacoub

Faculty of MedicineNational Heart & Lung Institute

Professor of Cardiothoracic Surgery
 
 
 
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Contact

 

+44 (0)1895 828 893m.yacoub

 
 
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Location

 

Heart Science Centre, HarefieldHarefield HospitalHarefield Hospital

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Summary

 

Publications

Publication Type
Year
to

1461 results found

Krishnamoorthy N, Tseng Y-T, Gajendrarao P, Sarathchandra P, McCormack A, Carubelli I, Sohier J, Latif N, Chester AH, Yacoub MHet al., 2018, A Strategy to Enhance Secretion of Extracellular Matrix Components by Stem Cells: Relevance to Tissue Engineering, TISSUE ENGINEERING PART A, Vol: 24, Pages: 145-156, ISSN: 1937-3341

JOURNAL ARTICLE

Mongkoldhumrongkul N, Latif N, Yacoub MH, Chester AHet al., 2018, Effect of Side-Specific Valvular Shear Stress on the Content of Extracellular Matrix in Aortic Valves, CARDIOVASCULAR ENGINEERING AND TECHNOLOGY, Vol: 9, Pages: 151-157, ISSN: 1869-408X

JOURNAL ARTICLE

Yacoub MH, Aguib H, Gamrah MA, Shehata N, Nagy M, Donia M, Aguib Y, Saad H, Romeih S, Torii R, Afifi A, Lee S-Let al., 2018, Aortic root dynamism, geometry, and function after the remodeling operation: Clinical relevance., J Thorac Cardiovasc Surg

OBJECTIVES: Valve-conserving operations for aneurysms of the ascending aorta and root offer many advantages, and their use is steadily increasing. Optimizing the results of these operations depends on providing the best conditions for normal function and durability of the new root. METHODS: Multimodality imaging including 2-dimensional echocardiography, multislice computed tomography, and cardiovascular magnetic resonance combined with image processing and computational fluid dynamics were used to define geometry, dynamism and aortic root function, before and after the remodeling operation. This was compared with 4 age-matched controls. RESULTS: The size and shape of the ascending aorta, aortic root, and its component parts showed considerable changes postoperatively, with preservation of dynamism. The postoperative size of the aortic annulus was reduced without the use of external bands or foreign material. Importantly, the elliptical shape of the annulus was maintained and changed during the cardiac cycle (Δ ellipticity index was 15% and 28% in patients 1 and 2, respectively). The "cyclic" area of the annulus changed in size (Δarea: 11.3% in patient 1 and 13.1% in patient 2). Functional analysis showed preserved reservoir function of the aortic root, and computational fluid dynamics demonstrated normalized pattern of flow in the ascending aorta, sinuses of Valsalva, and distal aorta. CONCLUSIONS: The remodeling operation results in near-normal geometry of the aortic root while maintaining dynamism of the aortic root and its components. This could have very important functional implications; the influence of these effects on both early- and long-term outcomes needs to be studied further.

JOURNAL ARTICLE

Yacoub MH, Hosny H, Romeih S, Aguib H, Simry W, Afifi A, Sedky Yet al., 2018, MID-TERM OUTCOME OF A MODIFIED MUSTARD OPERATION FOR NEGLECTED TRANSPOSITION OF THE GREAT ARTERIES, 67th Annual Scientific Session and Expo of the American-College-of-Cardiology (ACC), Publisher: ELSEVIER SCIENCE INC, Pages: 591-591, ISSN: 0735-1097

CONFERENCE PAPER

Dokainish H, Teo K, Zhu J, Roy A, AlHabib KF, ElSayed A, Palileo-Villaneuva L, Lopez-Jaramillo P, Karaye K, Yusoff K, Orlandini A, Sliwa K, Mondo C, Lanas F, Prabhakaran D, Badr A, Elmaghawry M, Damasceno A, Tibazarwa K, Belley-Cote E, Balasubramanian K, Islam S, Yacoub MH, Huffman MD, Harkness K, Grinvalds A, McKelvie R, Bangdiwala SI, Yusuf Set al., 2017, Global mortality variations in patients with heart failure: results from the International Congestive Heart Failure (INTER-CHF) prospective cohort study, LANCET GLOBAL HEALTH, Vol: 5, Pages: E665-E672, ISSN: 2214-109X

JOURNAL ARTICLE

El-Sherbiny I, Khalil I, Ali I, Yacoub Met al., 2017, Updates on smart polymeric carrier systems for protein delivery, DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, Vol: 43, Pages: 1567-1583, ISSN: 0363-9045

JOURNAL ARTICLE

El-Sherbiny IM, Elbaz NM, Sedki M, Elgammal A, Yacoub MHet al., 2017, Magnetic nanoparticles-based drug and gene delivery systems for the treatment of pulmonary diseases, NANOMEDICINE, Vol: 12, Pages: 387-402, ISSN: 1743-5889

JOURNAL ARTICLE

Gemechu T, Mahmoud H, Parry EHO, Phillips DIW, Yacoub MHet al., 2017, Community-based prevalence study of rheumatic heart disease in rural Ethiopia, EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, Vol: 24, Pages: 717-723, ISSN: 2047-4873

JOURNAL ARTICLE

Hassan M, Wagdy K, Kharabish A, Selwanos PP, Nabil A, Elguindy A, ElFaramawy A, Elmahdy MF, Mahmoud H, Yacoub MHet al., 2017, Validation of Noninvasive Measurement of Cardiac Output Using Inert Gas Rebreathing in a Cohort of Patients With Heart Failure and Reduced Ejection Fraction, CIRCULATION-HEART FAILURE, Vol: 10, ISSN: 1941-3289

JOURNAL ARTICLE

Jakovljevic DG, Yacoub MH, Schueler S, MacGowan GA, Velicki L, Seferovic PM, Hothi S, Tzeng B-H, Brodie DA, Birks E, Tan L-Bet al., 2017, Left Ventricular Assist Device as a Bridge to Recovery for Patients With Advanced Heart Failure, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 69, Pages: 1924-1933, ISSN: 0735-1097

JOURNAL ARTICLE

Mohamed NA, Davies RP, Lickiss PD, Ahmetaj-Shala B, Reed DM, Gashaw HH, Saleem H, Freeman GR, George PM, Wort SJ, Morales-Cano D, Barreira B, Tetley TD, Chester AH, Yacoub MH, Kirkby NS, Moreno L, Mitchell JAet al., 2017, Chemical and biological assessment of metal organic frameworks (MOFs) in pulmonary cells and in an acute in vivo model: relevance to pulmonary arterial hypertension therapy, PULMONARY CIRCULATION, Vol: 7, Pages: 643-653, ISSN: 2045-8932

JOURNAL ARTICLE

Porras AM, van Engeland NCA, Marchbanks E, McCormack A, Bouten CVC, Yacoub MH, Latif N, Masters KSet al., 2017, Robust Generation of Quiescent Porcine Valvular Interstitial Cell Cultures, JOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol: 6, ISSN: 2047-9980

JOURNAL ARTICLE

Salhiyyah K, Sarathchandra P, Latif N, Yacoub MH, Chester AHet al., 2017, Hypoxia-mediated regulation of the secretory properties of mitral valve interstitial cells, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 313, Pages: H14-H23, ISSN: 0363-6135

JOURNAL ARTICLE

Soliman AB, Haikal RR, Abugable AA, Hassan MH, Karakalos SG, Pellechia PJ, Hassan HH, Yacoub MH, Alkordi MHet al., 2017, Tailoring the Oxygen Reduction Activity of Hemoglobin through Immobilization within Microporous Organic Polymer-Graphene Composite, ACS APPLIED MATERIALS & INTERFACES, Vol: 9, Pages: 27918-27926, ISSN: 1944-8244

JOURNAL ARTICLE

Yacoub MH, 2017, RESPONSE: Trainees in Regional Centers of Excellence in the Developing World A Win-Win for Global Cardiology, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 69, Pages: 2463-2464, ISSN: 0735-1097

JOURNAL ARTICLE

Yacoub MH, Afifi A, Saad H, Aguib H, ElGuindy Aet al., 2017, Current state of the art and future of myectomy, ANNALS OF CARDIOTHORACIC SURGERY, Vol: 6, Pages: 307-317, ISSN: 2225-319X

JOURNAL ARTICLE

van Engeland NCA, Bertazzo S, Sarathchandra P, McCormack A, Bouten CVC, Yacoub MH, Chester AH, Latif Net al., 2017, Aortic calcified particles modulate valvular endothelial and interstitial cells, CARDIOVASCULAR PATHOLOGY, Vol: 28, Pages: 36-45, ISSN: 1054-8807

JOURNAL ARTICLE

Danial JSH, Aguib Y, Yacoub MH, 2016, Advanced fluorescence microscopy techniques for the life sciences., Glob Cardiol Sci Pract, Vol: 2016, ISSN: 2305-7823

The development of super-resolved fluorescence microscopy, for which the Nobel Prize was awarded in 2014, has been a topic of interest to physicists and biologists alike. It is inevitable that numerous questions in biomedical research cannot be answered by means other than direct observation. In this review, advances to fluorescence microscopy are covered in a widely accessible fashion to facilitate its use in decisions related to its acquisition and utilization in biomedical research.

JOURNAL ARTICLE

Dokainish H, Teo K, Zhu J, Roy A, AlHabib KF, ElSayed A, Palileo-Villaneuva L, Lopez-Jaramillo P, Karaye K, Yusoff K, Orlandini A, Sliwa K, Mondo C, Lanas F, Prabhakaran D, Badr A, Elmaghawry M, Damasceno A, Tibazarwa K, Belley-Cote E, Balasubramanian K, Yacoub MH, Huffman MD, Harkness K, Grinvalds A, McKelvie R, Yusuf Set al., 2016, Heart Failure in Africa, Asia, the Middle East and South America: The INTER-CHF study, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 204, Pages: 133-141, ISSN: 0167-5273

JOURNAL ARTICLE

El-Hamamsy I, Yacoub MH, 2016, Towards More Personalized Surgical Indications for Thoracic Aortic Dilatation: Are We There Yet?, CANADIAN JOURNAL OF CARDIOLOGY, Vol: 32, Pages: 4-7, ISSN: 0828-282X

JOURNAL ARTICLE

Kaniewska-Bednarczuk E, Mielcarek M, Chester AH, Slominska EM, Yacoub MH, Smolenski RTet al., 2016, Oxidized low-density lipoproteins enhance expression and activity of CD39 and CD73 in the human aortic valve endothelium, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, Vol: 35, Pages: 713-719, ISSN: 1525-7770

JOURNAL ARTICLE

Kutryb-Zajac B, Yuen AHY, Khalpey Z, Zukowska P, Slominska EM, Taylor PM, Goldstein S, Heacox AE, Lavitrano M, Chester AH, Yacoub MH, Smolenski RTet al., 2016, Nucleotide Catabolism on the Surface of Aortic Valve Xenografts; Effects of Different Decellularization Strategies, JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 9, Pages: 119-126, ISSN: 1937-5387

JOURNAL ARTICLE

Lee S-L, Aguib H, Chapron J, Bahmanyar R, Borghi A, Murphy O, McLeod C, ElGuindy A, Yacoub Met al., 2016, Spatial Orientation and Morphology of the Pulmonary Artery: Relevance to Optimising Design and Positioning of a Continuous Pressure Monitoring Device, JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 9, Pages: 239-248, ISSN: 1937-5387

JOURNAL ARTICLE

Mohamed NA, Ahmetaj-Shala B, Duluc L, Mackenzie LS, Kirkby NS, Reed DM, Lickiss PD, Davies RP, Freeman GR, Wojciak-Stothard B, Chester AH, El-Sherbiny IM, Mitchell JA, Yacoub MHet al., 2016, A New NO-Releasing Nanoformulation for the Treatment of Pulmonary Arterial Hypertension, JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, Vol: 9, Pages: 162-164, ISSN: 1937-5387

JOURNAL ARTICLE

Mongkoldhumrongkul N, Yacoub MH, Chester AH, 2016, Valve Endothelial Cells - Not Just Any Old Endothelial Cells, CURRENT VASCULAR PHARMACOLOGY, Vol: 14, Pages: 146-154, ISSN: 1570-1611

JOURNAL ARTICLE

Spadotto V, Voges I, Kilner PJ, Yacoub MH, Ernst S, Ho SY, Babu-Narayan SVet al., 2016, Juxtaposition of the atrial appendages: A nidus for thrombus in atriopulmonary Fontan?, Glob Cardiol Sci Pract, Vol: 2016, ISSN: 2305-7823

Juxtaposition of atrial appendages is a rare cardiac congenital anomaly, usually associated with other cardiac malformations. Until now, it has not been linked to any significant clinical implications. We report cardiovascular magnetic resonance (CMR) findings of two adult patients who underwent atriopulmonary Fontan operation in the setting of left juxtaposition of the atrial appendages. The patients were in sinus rhythm at the time of the CMR study. Both patients had episodes of sustained atrial tachyarrhythmia requiring electrical cardioversion and were anticoagulated with warfarin with target INR 2-3. CMR images showed a thrombus located in the enlarged and juxtaposed right appendage in both patients. Blood flow frequently appears slow or sluggish in the dilated right atrium following atriopulmonary Fontan surgery. In addition, cine CMR suggested that blood flow reaches very low velocities in the massively dilated juxtaposed right atrial appendage cul-de-sac, thus potentially creating a substrate for clot formation. These findings propose that juxtaposed atrial appendages in atriopulmonary Fontan is an additional risk factor for clot formation, specifically in the dilated right atrial appendage on the left side juxtaposed with the left atrial appendage and that prophylactic anticoagulation is highly justified in these patients.

JOURNAL ARTICLE

Torii R, Parker KH, Yacoub MH, 2016, Importance of Stress Mapping of Aortic Wall in Aortic Valve Disease, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 67, Pages: 1755-1756, ISSN: 0735-1097

JOURNAL ARTICLE

Allouba MH, ElGuindy AM, Krishnamoorthy N, Yacoub MH, Aguib YEet al., 2015, NaNog: A pluripotency homeobox (master) molecule., Glob Cardiol Sci Pract, Vol: 2015, ISSN: 2305-7823

One of the most intriguing aspects of cell biology is the state of pluripotency, where the cell is capable of self-renewal for as many times as deemed "necessary", then at a specified time can differentiate into any type of cell. This fundamental process is required during organogenesis in foetal life and importantly during tissue repair in health and disease. Pluripotency is very tightly regulated, as any dysregulation can result in congenital defects, inability to repair damage, or cancer. Fuelled by the relatively recent interest in stem cell biology and tissue regeneration, the molecules implicated in regulating pluripotency have been the subject of extensive research. One of the important molecules involved in pluripotency, is NaNog, the subject of this article.

JOURNAL ARTICLE

Backhaus J, Yacoub L, Kambaris A, Wright G, Yacoub MHet al., 2015, The Burundi Heart Centre: From concept to design., Glob Cardiol Sci Pract, Vol: 2015, ISSN: 2305-7823

Burundi is one of the world's poorest nations, which is also reflected in its relative lack of cardiac facilities, particularly those catering to young children and adults. The authors discuss current efforts to build "The Burundi Heart Centre" to help address this challenge. In particular, they highlight how the project can act as a case study for a sustainable architecture that involves local people and uses locally available materials in a contemporary and innovative way.

JOURNAL ARTICLE

Balbaa A, ElGuindy A, Pericak D, Yacoub MH, Schwalm JDet al., 2015, An evaluation of secondary prophylaxis for rheumatic heart disease in rural Egypt., Glob Cardiol Sci Pract, Vol: 2015, ISSN: 2305-7823

BACKGROUND: Although essentially disappeared from the industrialized world, rheumatic heart disease (RHD) is still prevalent in developing countries, with 300,000 new cases identified each year. In Aswan, Egypt, RHD affects about 2.3% of children with over 90% of the cases being subclinical. Secondary prophylaxis has proved to be an effective method of preventing the progression of RHD. However, its efficacy is limited by low patient adherence. A systematic, generalizable tool is necessary to outline, and ultimately address these barriers. METHODS: A 43-item semi-structured questionnaire was developed based on the three domains outlined by Fishbein (capability, intention, and health care barriers). A preliminary evaluation of the barriers to RHD prophylaxis use in Aswan, Egypt was carried out as a pilot study using this tool. Participants were local school children diagnosed with RHD or flagged as high-risk (as per a set of echocardiographic criteria developed by the Aswan Heart Centre) through a previous screening program of randomly selected 3,062 school children in Aswan. RESULTS: 29 patients were interviewed (65.5% adherent to RHD prophylaxis). Compared to non-adherent patients, adherent patients had better understanding of the disease (68.4% versus 20% in the non-adherent group, p = 0.021), and were more aware of the consequences of missing prophylaxis doses (79% versus 40% of non-adherent patients, p = 0.005). Furthermore, 90% of non-adherent patients consciously choose to miss injection appointments (as compared to 31.6% of adherent patients, p = 0.005). Clinic wait time was the most frequently reported deterrent for both groups. CONCLUSION: A standardized tool that systematically outlines barriers to prophylaxis is a necessary first step to improving adherence to penicillin. Although individually developed tools exist for specific populations, a generalizable tool that takes into account the demographic and cultural differences

JOURNAL ARTICLE

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