Publications
2088 results found
Al Kindi HN, Elsawy A, Fahmi YR, et al., 2019, Progression of arterial toursosity syndrome to multiple aneurysms: Role of defining aortic flow and biomechanics, Global Cardiology Science and Practice, Vol: 2019
Arterial tortuosity syndrome (ATS) is a rare aortopathy characterized by multiple areas of tortuosity, stenosis and aneurysms in large and mid-sized arteries. The management of this syndrome is challenging because its complexity and variability in presentation and progression require a thorough understanding of the biological and biomechanical changes that occur in the arterial system. Here we describe, for the first time, the progression of this disease diagnosed in a 3-year old girl and the use of modern imaging modalities including cardiac magnetic resonance (CMR) 4D Flow, 3D modeling, and computational fluid dynamic simulation to characterize the complex aortic flow and its biomechanics. The integration of these modalities with the clinical evaluation will help in our understanding of this disease and provide patient-specific management.
Yacoub M, Nagy M, Hosny H, et al., 2019, Right ventricular crypts in a myocardial bridge: Relevance to surgical relief, Global Cardiology Science and Practice, Vol: 2019
Crypts are very thin walled invaginations from the cavity of the left ventricle into the compact myocardium. With the advent and increased application of multimodality imaging, crypts are being increasingly identified in both normal individuals and patients, with various conditions including HCM, before and after the development of LV hypertrophy, LV non-compaction and hypertensive heart disease. to date crypts have not been described in the right ventricle. We here describe for the first time, RV crypts which were extending into a myocardial bridge, in a patient with HCM and dynamic obstruction of the LAD coronary artery. We also document and discuss the serious complications which can arise from crypts, and highlight the importance of preoperative identification of crypts. Further studies are required to determine the fetal origin of crypts and their clinical significance.
Cavigli L, Fumagalli C, Maurizi N, et al., 2018, Timing of invasive septal reduction therapies and outcome of patients with obstructive hypertrophic cardiomyopathy, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 273, Pages: 155-161, ISSN: 0167-5273
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- Citations: 14
Mazine A, El-Hamamsy I, Verma S, et al., 2018, Ross Procedure in Adults for Cardiologists and Cardiac Surgeons <i>JACC</i> State-of-the-Art Review, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 72, Pages: 2761-2777, ISSN: 0735-1097
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- Citations: 103
Zilla P, Bolman RM, Yacoub MH, et al., 2018, The Cape Town Declaration on access to cardiac surgery in the developing world, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol: 156, Pages: 2206-2209, ISSN: 0022-5223
Karamichalis JM, Aguib H, Anastasopulos A, et al., 2018, Surgical relief of left ventricular outflow obstruction in pediatric hypertrophic cardiomyopathy: The need for a tailored approach., J Thorac Cardiovasc Surg, Vol: 156, Pages: 2283-2284
Zilla P, Yacoub M, Zuhlke L, et al., 2018, Global Unmet Needs in Cardiac Surgery, GLOBAL HEART, Vol: 13, Pages: 293-303, ISSN: 2211-8160
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- Citations: 101
Yacoub MH, McLeod C, 2018, The expanding role of implantable devices to monitor heart failure and pulmonary hypertension, NATURE REVIEWS CARDIOLOGY, Vol: 15, Pages: 770-779, ISSN: 1759-5002
Yu JK, Sarathchandra P, Chester A, et al., 2018, Cardiac regeneration following cryoinjury in the adult zebrafish targets a maturation-specific biomechanical remodeling program, Scientific Reports, Vol: 8, ISSN: 2045-2322
Cardiac regeneration post-injury is a tantalizing feature of many lower vertebrates such as fishes and urodeles, but absent in adult humans. Restoration of pumping function is a key endpoint of cardiac regeneration, but very little is known about the biomechanical remodeling process. Here, we quantify and compare the evolution of cellular composition and mechanical stiffness of the zebrafish ventricular myocardium during maturation and following cryoinjury during regeneration to better understand the dynamics of biomechanical remodeling during these two processes. With increasing age, normal myocardial trabecular density and cardiomyocyte fraction increased, while non-myocyte cell fractions decreased. Cell density remained constant during maturation. Cardiomyocyte sarcomeres shortened to a minimum reached at 7.5 months of age, but lengthened with additional age. Concomitantly, ventricular wall stiffness increased up until 7.5 months before plateauing with additional age. Endothelial, myofibroblast/smooth muscle, and cardiomyocyte cell fractions were disrupted following cryoinjury, but were progressively restored to age-specific natural norms by 35 days post infarct (DPI). Infarcted myocardium stiffened immediately following cryoinjury and was a 100-fold greater than non-infarcted tissue by 3 DPI. By 14 DPI, stiffness of the infarcted myocardium had fallen below that of 0 DPI and had completely normalized by 35 DPI. Interestingly, cardiomyocyte sarcomere length increased until 14 DPI, but subsequently shortened to lengths below age-specific natural norms, indicating recovery from a volume overloaded condition. These observations are consistent with the view that regenerating myocardium requires biomechanical stimulation (e.g. strain) to rescue from a volume overloaded condition. Intriguingly, the biomechanical progression of the infarcted adult myocardial wall mirrors that of normal remodeling during aging. The biomechanical progression of the infarcted myocardium ta
Yacoub M, 2018, The Ross Operation Comes of Age., JAMA Cardiol, Vol: 3
Watkins DA, Beaton AZ, Carapetis JR, et al., 2018, Rheumatic Heart Disease Worldwide <i>JACC</i> Scientific Expert Panel, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 72, Pages: 1397-1416, ISSN: 0735-1097
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- Citations: 89
Zilla P, Bolman RM, Yacoub MH, et al., 2018, The Cape Town Declaration on Access to Cardiac Surgery in the Developing World., Asian Cardiovasc Thorac Ann, Vol: 26, Pages: 535-539
Zilla P, Bolman RM, Yacoub MH, et al., 2018, The Cape Town declaration on access to cardiac surgery in the developing world, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 54, Pages: 407-410, ISSN: 1010-7940
Zilla P, Bolman RM, Yacoub MH, et al., 2018, The Cape Town Declaration on Access to Cardiac Surgery in the Developing World, ANNALS OF THORACIC SURGERY, Vol: 106, Pages: 930-933, ISSN: 0003-4975
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- Citations: 16
Yacoub MH, Aguib H, Abou Gamrah M, et al., 2018, Aortic root dynamism, geometry, and function after the remodeling operation: Clinical relevance, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol: 156, Pages: 951-+, ISSN: 0022-5223
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- Citations: 8
Zilla P, Bolman RM, Yacoub MH, et al., 2018, The Cape Town Declaration on Access to Cardiac Surgery in the Developing World, SAMJ SOUTH AFRICAN MEDICAL JOURNAL, Vol: 108, Pages: 702-704, ISSN: 0256-9574
Rich S, Haworth SG, Hassoun PM, et al., 2018, Pulmonary hypertension: the unaddressed global health burden, LANCET RESPIRATORY MEDICINE, Vol: 6, Pages: 577-579, ISSN: 2213-2600
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- Citations: 18
Zilla P, Bolman RM, Yacoub MH, et al., 2018, The Cape Town Declaration on Access to Cardiac Surgery in the Developing World, CARDIOVASCULAR JOURNAL OF AFRICA, Vol: 29, Pages: 256-259, ISSN: 1995-1892
Afifi A, Hosny H, Yacoub M, 2018, Predicting the future by looking at the past: necessary but not binding., Eur Heart J, Vol: 39, Pages: 2190-2191
Kaniewska-Bednarczuk E, Kutryb-Zajac B, Sarathchandra P, et al., 2018, CD39 and CD73 in the aortic valve-biochemical and immunohistochemical analysis in valve cell populations and its changes in valve mineralization, CARDIOVASCULAR PATHOLOGY, Vol: 36, Pages: 53-63, ISSN: 1054-8807
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- Citations: 4
Mongkoldhumrongkul N, Latif N, Yacoub MH, et al., 2018, Effect of side-specific valvular shear stress on the content of extracellular matrix in aortic valves, Cardiovascular Engineering and Technology, Vol: 9, Pages: 151-157, ISSN: 1869-4098
Responses of valve endothelial cells (VECs) to shear stresses are important for the regulation of valve durability. However, the effect of flow patterns subjected to VECs on the opposite surfaces of the valves on the production of extracellular matrix (ECM) has not yet been investigated. This study aims to investigate the response of side-specific flow patterns, in terms of ECM synthesis and/or degradation in porcine aortic valves. Aortic and ventricular sides of aortic valve leaflets were exposed to oscillatory and laminar flow generated by a Cone-and-Plate machine for 48 h. The amount of collagen, GAGs and elastin was quantified and compared to samples collected from the same leaflets without exposing to flow. The results demonstrated that flow is important to maintain the amount of GAGs and elastin in the valve, as compared to the effect of static conditions. Particularly, the laminar waveform plays a crucial role on the modulation of elastin in side-independent manner. Furthermore, the ability of oscillatory flow on the aortic surface to increase the amount of collagen and GAGs cannot be replicated by exposure of an identical flow pattern on the ventricular side of the valve. Side-specific responses to the particular patterns of flow are important to the regulation of ECM components. Such understanding is imperative to the creation of tissue-engineered heart valves that must be created from the “appropriate” cells that can replicate the functions of the native VECs to regulate the different constituents of ECM.
Yacoub MH, Hosny H, Romeih S, et al., 2018, MID-TERM OUTCOME OF A MODIFIED MUSTARD OPERATION FOR NEGLECTED TRANSPOSITION OF THE GREAT ARTERIES, 67th Annual Scientific Session and Expo of the American-College-of-Cardiology (ACC), Publisher: ELSEVIER SCIENCE INC, Pages: 591-591, ISSN: 0735-1097
Mahmoud Elsayed HM, Hassan M, Nagy M, et al., 2018, A novel method to measure mitral valve area in patients with rheumatic mitral stenosis using three-dimensional transesophageal echocardiography: Feasibility and validation., Echocardiography, Vol: 35, Pages: 368-374
AIMS: Neither two- nor three-dimensional (3D) planimetry of the mitral valve (MV) orifice takes the mitral commissures into account. Thus, if the commissures are not completely fused, the MV orifice will not be planar, and MV area (MVA) will be underestimated. The study aimed to validate a novel method for measurement of the MVA using a software that traces the MV orifice including the commissures. METHODS AND RESULTS: The study included 30 patients undergoing percutaneous balloon mitral valvuloplasty for severe rheumatic mitral stenosis. All performed 3D transesophageal echocardiography (TEE) immediately before the procedure. MVA was measured using the mitral valve navigation (MVN) software of the Philips Q-Lab 10.2 in a diastolic frame with maximum diastolic opening of the MV. Regular 3D planimetry of the MV orifice was also performed. Before balloon dilation, the MVA was calculated invasively using the Gorlin's formula. No significant difference was detected between MVN-derived MVA and Gorlin-derived MVA (0.98 cm2 vs. 1.0 cm2 , P = .33). A statistically significant difference was detected between Planimetry-derived MVA and Gorlin-derived MVA (0.8 cm2 vs. 1.0 cm2 , P < .001). There were significant linear correlations between MVN-derived MVA and Gorlin-derived MVA (r = .84, P < .001). Using Bland-Altman analysis, Gorlin-derived MVA showed better and relatively narrower limits of agreement with MVN-derived MVA than planimetry-derived MVA. CONCLUSION: Measurement of the MVA using the MVN method is feasible and is more correlated to the invasively measured MVA than the 3D planimetry method. This is the most accurate method of measuring the MVA that takes MV commissures into account.
Al Kindi HN, Yacoub MH, 2018, Surgical myectomy: Rationale and personalized technique
Septal myectomy is currently the gold standard treatment for symptomatic patients with hypertrophic cardiomyopathy. The procedure needs to be tailored and performed in a personalized fashion, taking into consideration the anatomical spectrum of this disease. The procedure needs to address the various components that contribute to the clinical and pathological picture of this disease including, the fibrous trigones, accessory tissues, papillary muscles, mitral valve and myocardial bridges. The operation can be performed with very low mortality and morbidity in high-volume experienced centers with predictable excellent short and long-term outcomes. There is a need for broadening the experience of this procedure to the rest of the world and for future development of new enhanced precision imaging and surgical tools.
Yacoub M, Bonow RO, 2018, Introduction to the special issue, Global Cardiology Science and Practice, Vol: 2018
Yacoub M, Khaghani A, 2018, Heart transplantation at 50+: Celebrations and challenges, Global Cardiology Science and Practice, Vol: 2018
Namuyonga J, Lwabi PS, Omagino J, et al., 2018, Feasibility of south-south collaboration in Africa: the Uganda-Mozambique perspective., Cardiovasc J Afr, Vol: 29, Pages: 262-263
Haikal RR, Hua C, Perry JJ, et al., 2017, Controlling the Uptake and Regulating the Release of Nitric Oxide in Microporous Solids, ACS APPLIED MATERIALS & INTERFACES, Vol: 9, Pages: 43520-43528, ISSN: 1944-8244
Yacoub M, 2017, Heart Transplants, Reflections, & Expectations: Sir Magdi Yacoub reviews the history of heart transplantation and discusses expectations., Eur Heart J, Vol: 38, Pages: 3420-3422
You AYF, Bergholt MS, St-Pierre JP, et al., 2017, Raman spectroscopy imaging reveals interplay between atherosclerosis and medial calcification in human aorta, Science Advances, Vol: 3, ISSN: 2375-2548
Medial calcification in the human aorta accumulates during aging and is known to be aggravated in several diseases. Atherosclerosis, another major cause of cardiovascular calcification, shares some common aggravators. However, the mechanisms of cardiovascular calcification remain poorly understood. To elucidate the relationship between medial aortic calcification and atherosclerosis, we characterized the cross-sectional distributions of the predominant minerals in aortic tissue, apatite and whitlockite, and the associated extracellular matrix. We also compared the cellular changes between atherosclerotic and nonatherosclerotic human aortic tissues. This was achieved through the development of Raman spectroscopy imaging methods that adapted algorithms to distinguish between the major biomolecules present within these tissues. We present a relationship between apatite, cholesterol, and triglyceride in atherosclerosis, with the relative amount of all molecules concurrently increased in the atherosclerotic plaque. Further, the increase in apatite was disproportionately large in relation to whitlockite in the aortic media directly underlying a plaque, indicating that apatite is more pathologically significant in atherosclerosis-aggravated medial calcification. We also discovered a reduction of β-carotene in the whole aortic intima, including a plaque in atherosclerotic aortic tissues compared to nonatherosclerotic tissues. This unprecedented biomolecular characterization of the aortic tissue furthers our understanding of pathological and physiological cardiovascular calcification events in humans.
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