Imperial College London
Portrait Picture

DrMariaPapathanasiou

Faculty of Engineering, Department of Chemical Engineering

Senior Lecturer
 
 
 
//

Contact

 

maria.papathanasiou11

 
 
//

Location

 

RODH.501DRoderic Hill BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Papathanasiou:2016:10.1002/aic.15203,
author = {Papathanasiou, MM and Avraamidou, S and Oberdieck, R and Mantalaris, A and Steinebach, F and Morbidelli, M and Mueller-Spaeth, T and Pistikopoulos, EN},
doi = {10.1002/aic.15203},
journal = {AIChE Journal},
pages = {2341--2357},
title = {Advanced control strategies for the multicolumn countercurrent solvent gradient purification process},
url = {http://dx.doi.org/10.1002/aic.15203},
volume = {62},
year = {2016}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The multicolumn countercurrent solvent gradient purification process (MCSGP) is a semicontinuous, chromatographic separation process used in the production of monoclonal antibodies) . The process is characterized by high model complexity and periodicity that challenge the development of control strategies, necessary for feasible and efficient operation and essential toward continuous production. A novel approach for the development of control policies for the MCSGP process, which enables efficient continuous process control is presented. Based on a high fidelity model, the recently presented PAROC framework and software platform that allows seamless design and in-silico validation of advanced controllers for complex systems are followed. The controller presented in this work is successfully tested against disturbances and is shown to efficiently capture the process periodic nature.
AU  - Papathanasiou,MM
AU  - Avraamidou,S
AU  - Oberdieck,R
AU  - Mantalaris,A
AU  - Steinebach,F
AU  - Morbidelli,M
AU  - Mueller-Spaeth,T
AU  - Pistikopoulos,EN
DO  - 10.1002/aic.15203
EP  - 2357
PY  - 2016///
SN  - 0001-1541
SP  - 2341
TI  - Advanced control strategies for the multicolumn countercurrent solvent gradient purification process
T2  - AIChE Journal
UR  - http://dx.doi.org/10.1002/aic.15203
UR  - https://aiche.onlinelibrary.wiley.com/doi/abs/10.1002/aic.15203
VL  - 62
ER  -
Download