Imperial College London
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DrMariaYanez Lopez

Faculty of Medicine, Department of Brain Sciences

Honorary Research Associate
 
 
 
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Contact

 

maria.yanez-lopez

 
 
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Location

 

C3NLBurlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Yanez:2019:10.1371/journal.pone.0212002,
author = {Yanez, Lopez M and Pardon, M-C and Baiker, K and Prior, M and Yuchun, D and Agostini, A and Bai, L and Auer, DP and Faas, HM},
doi = {10.1371/journal.pone.0212002},
journal = {PLoS ONE},
title = {Myoinositol CEST signal in animals with increased Iba-1 levels in response to an inflammatory challenge-Preliminary findings},
url = {http://dx.doi.org/10.1371/journal.pone.0212002},
volume = {14},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Neuroinflammation plays an important role in the pathogenesis of a range of brain disorders. Non-invasive imaging of neuroinflammation is critical to help improve our understanding of the underlying disease mechanisms, monitor therapies and guide drug development. Generally, MRI lacks specificity to molecular imaging biomarkers, but molecular MR imaging based on chemical exchange saturation transfer (CEST) can potentially detect changes of myoinositol, a putative glial marker that may index neuroinflammation. In this pilot study we aimed to investigate, through validation with immunohistochemistry and in vivo magnetic resonance spectroscopy (MRS), whether CEST imaging can reflect the microglial response to a mild inflammatory challenge with lipopolysaccharide (LPS), in the APPSwe/ PS1 mouse model of Alzheimer's disease and wild type controls. The response to the immune challenge was variable and did not align with genotype. Animals with a strong response to LPS (Iba1+, n = 6) showed an increase in CEST contrast compared with those who did not (Iba1-, n = 6). Changes of myoinositol levels after LPS were not significant. We discuss the difficulties of this mild inflammatory model, the role of myoinositol as a glial biomarker, and the technical challenges of CEST imaging at 0.6ppm.
AU  - Yanez,Lopez M
AU  - Pardon,M-C
AU  - Baiker,K
AU  - Prior,M
AU  - Yuchun,D
AU  - Agostini,A
AU  - Bai,L
AU  - Auer,DP
AU  - Faas,HM
DO  - 10.1371/journal.pone.0212002
PY  - 2019///
SN  - 1932-6203
TI  - Myoinositol CEST signal in animals with increased Iba-1 levels in response to an inflammatory challenge-Preliminary findings
T2  - PLoS ONE
UR  - http://dx.doi.org/10.1371/journal.pone.0212002
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30789943
UR  - http://hdl.handle.net/10044/1/69592
VL  - 14
ER  -
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