Imperial College London


Faculty of MedicineDepartment of Medicine

Honorary Clinical Senior Lecturer



+44 (0)20 3313 3754marios.politis Website




Room 101Block B Hammersmith HospitalHammersmith Campus





Marios Politis (MD MSc DIC PhD) is a Visiting Clinical Senior Lecturer in Neurology and Principal Investigator in the Neurology Imaging Unit within the Department of Medicine at Imperial College London. He is a full-time Clinical Senior Lecturer and Consultant Neurologist at King’s College London (KCL), and is the Head of Neurodegeneration Imaging Group (NIG) at KCL.

His research involves the use of molecular (PET) and functional (fMRI) imaging as a method of investigating aetiology, pathophysiology, and effects and complications of novel therapies in Neurodegenerative disorders. His high quality research has led to a body of scientific work investigating the pathophysiology of movement disorders such as Parkinson’s and Huntington’s disease and to publications in high impact scientific journals including Science Translational Medicine, Journal of Clinical Investigation, Brain, Neurology and JAMA Neurology. Dr Politis is a recipient of fellowships and grant project awards from the Michael J Fox Foundation for Parkinson’s research, Parkinson’s UK and the NIHR Biomedical Research Centre.

He has achieved a number of awards and distinctions including the Award for Outstanding and Innovative Clinical Research during the 16th International Congress of Parkinson's Disease and Movement Disorders in Dublin. In 2010, his PET imaging work in transplantation of foetal ventral mesencephalic tissue in Parkinson's Disease patients was classed as one of the most important research achievements of MRC-funded research.

Dr Politis graduated in Medicine from the University of Athens, Greece, and he obtained an MSc and the Diploma of Imperial College in Integrative Neuroscience. He holds a PhD in Clinical Neuroscience from Imperial College London. He has previously worked as a clinical research fellow at University College London (UCL) and Imperial College. He is a former Research Investigator of Hammersmith’s’ Cyclotron PET Neurology MRC CSC group, in which he received intense training for six years. He has industry experience by serving as a clinical imaging investigator for several PET Imaging trials.

Dr Politis is regularly invited to give talks to national and international scientific meetings. In 2012, he was invited to give a Presidential Lecture in the International Congress of Parkinson’s Disease and Movement Disorders. He also regularly contributes to the teaching and training of undergraduate and postgraduate students.

Dr Politis is a scientific advisor to the French National Research Agency (ANR), and a scientific advisory board member of the Network of European CNS Transplantation and Restoration (NECTAR), and member of European Parkinson’s transplantation trial development group (TRANSEURO). He is an active member of American Academy of Neurology, Movement Disorder Society, British Neuroscience Association, and a Fellow of Royal Society of Medicine.

Selected Publications

Journal Articles

Loane C, Wu K, Bain P, et al., 2013, Serotonergic loss in motor circuitries correlates with severity of action-postural tremor in PD, Neurology, Vol:80, ISSN:0028-3878, Pages:1850-1855

Politis M, Loane C, Wu K, et al., 2013, Neural response to visual sexual cues in dopamine treatment-linked hypersexuality in Parkinson's disease, Brain, Vol:136, ISSN:0006-8950, Pages:400-411

Politis M, Wu K, Loane C, et al., 2012, Serotonin Neuron Loss and Nonmotor Symptoms Continue in Parkinson's Patients Treated with Dopamine Grafts, Science Translational Medicine, Vol:4, ISSN:1946-6234

Politis M, Wu K, Loane C, et al., 2010, Serotonergic Neurons Mediate Dyskinesia Side Effects in Parkinson's Patients with Neural Transplants, Science Translational Medicine, Vol:2, ISSN:1946-6234

Politis M, Pavese N, Tai YF, et al., 2008, Hypothalamic involvement in Huntingtons disease: an in vivo PET study, Brain, Vol:131, ISSN:0006-8950, Pages:2860-2869

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