Publications
465 results found
Ogueh O, Hills FA, Chard T, et al., 1998, Antenatal dexamethasone therapy does not affect circulating concentrations of insulin-like growth factor binding protein-1, HUMAN REPRODUCTION, Vol: 13, Pages: 1714-1716, ISSN: 0268-1161
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- Citations: 3
Ogueh O, Khastgir G, Studd J, et al., 1998, The relationship of fetal serum markers of bone metabolism to gestational age, EARLY HUMAN DEVELOPMENT, Vol: 51, Pages: 109-112, ISSN: 0378-3782
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- Citations: 18
Ogueh O, Khastgir G, Studd JWW, et al., 1998, Antenatal corticosteroid therapy and risk of osteoporosis, BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 105, Pages: 551-555, ISSN: 0306-5456
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- Citations: 14
Ogueh O, Johnson MR, 1998, What is the value of hospitalisation in antepartum haemorrhage of uncertain origin?, J Obstet Gynaecol, Vol: 18, Pages: 120-122, ISSN: 0144-3615
This retrospective analysis was designed to determine the need for hospitalisation in cases of antepartum haemorrhage of uncertain origin (AUO). All the cases of AUO that presented at the Chelsea and Westminster Hospital from February 1993 to December 1995 were analysed. AUO accounted for 72% of cases of antepartum, haemorrhage Hospitalisation of the cases of AUO conferred no benefit in terms of gestation at delivery, birth weight centile, 5 minutes Apgar score and recurrent haemorrhage. Also, the duration of stay in hospital was not significantly related to the gestation at delivery ( r = 0.084, P > 0.05), the birth weight centile ( r = 0.032, P > 0.05) or the Apgar score at 5 minutes ( r = 0.062, P > 0.05). We conclude that it is not necessary to hospitalise women with AUO in the absence of heavy or repeated bleeding, evidence of fetal or maternal compromise on any suggestion of the onset of labour.
Brooks AA, Johnson MR, Pawson ME, et al., 1996, Endometrial thickness: individual and mean growth profiles for different hormone replacement regimens., Hum Reprod, Vol: 11, Pages: 2724-2731, ISSN: 0268-1161
Currently, there is a paucity of data describing endometrial growth, with most studies concentrating on endometrial thickness immediately prior to implantation or embryo transfer. This study looked at the individual and combined growth profiles of 67 volunteers receiving three different hormone replacement regimens. Each treatment regimen was in excess of that considered necessary for optimal growth, and all promoted an endometrial thickness that would be considered satisfactory for embryo transfer. Three patterns of growth were identified, but overall there was a decrease in the rate of endometrial growth with duration of treatment. As expected, analysis of variance did not show a significant difference between the mean growth profiles for the three hormone replacement regimens. The correlation (r = 0.45, P < 0.0001) between rank order on day 3 and day 10 of treatment indicates that interim analysis during early treatment cannot accurately predict later thickness, but a doubling of endometrial thickness can be expected in most cases. A relationship between endometrial thickness and either the treatment dose or serum concentrations of oestradiol was not found. These findings suggest that manipulation of endometrial growth is not possible by adjustment of either the treatment dose or serum concentration. The findings indicate that treatment beyond 12 days does not promote either a clinically significant increase in endometrial thickness of an excessive thickness, suggesting that maintenance of an oocyte recipient in a pseudo-follicular phase is unlikely to be disadvantageous to implantation.
Allman ACJ, Genevier ESG, Johnson MR, et al., 1996, Head-to-cervix force: An important physiological variable in labour .2. Peak active force, peak active pressure and mode of delivery, BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 103, Pages: 769-775, ISSN: 0306-5456
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- Citations: 28
Allman ACJ, Genevier ESG, Johnson MR, et al., 1996, Head-to-cervix force: An important physiological variable in labour .1. The temporal relation between head-to-cervix force and intrauterine pressure during labour, BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 103, Pages: 763-768, ISSN: 0306-5456
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- Citations: 25
Johnson MR, Brooks AA, Steer PJ, 1996, The role of relaxin in the pregnancy associated reduction in plasma osmolality, HUMAN REPRODUCTION, Vol: 11, Pages: 1105-1108, ISSN: 0268-1161
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- Citations: 14
Ramsay B, Sooranna SR, Johnson MR, 1996, Nitric oxide synthase activities in human myometrium and villous trophoblast throughout pregnancy, OBSTETRICS AND GYNECOLOGY, Vol: 87, Pages: 249-253, ISSN: 0029-7844
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- Citations: 78
HUGHES SCC, JOHNSON MR, HEINRICH G, et al., 1995, COULD ABNORMALITIES IN INSULIN-LIKE GROWTH-FACTORS AND THEIR BINDING-PROTEINS DURING PREGNANCY RESULT IN GESTATIONAL DIABETES, JOURNAL OF ENDOCRINOLOGY, Vol: 147, Pages: 517-524, ISSN: 0022-0795
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- Citations: 15
BROOKS AA, JOHNSON MR, STEER PJ, et al., 1995, BIRTH-WEIGHT - NATURE OR NURTURE, EARLY HUMAN DEVELOPMENT, Vol: 42, Pages: 29-35, ISSN: 0378-3782
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- Citations: 131
RAMSAY B, JOHNSON MR, LEONE AM, et al., 1995, THE EFFECT OF EXOGENOUS ESTROGEN ON NITRIC-OXIDE PRODUCTION IN WOMEN - A PLACEBO-CONTROLLED CROSSOVER STUDY, BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 102, Pages: 417-419, ISSN: 0306-5456
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- Citations: 37
JOHNSON MR, BROOKS AA, ABDALLA HI, et al., 1995, SERUM CONCENTRATIONS OF LUTEINIZING-HORMONE AND PROGESTERONE IN OVUM RECIPIENTS - THEIR RELATIONSHIP WITH PREGNANCY AND MISCARRIAGE, HUMAN REPRODUCTION, Vol: 10, Pages: 1228-1231, ISSN: 0268-1161
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- Citations: 1
JOHNSON MR, IRVINE R, HILLS F, et al., 1995, SUPEROVULATION, IGFBP-1 AND BIRTH-WEIGHT, EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, Vol: 59, Pages: 193-195, ISSN: 0301-2115
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- Citations: 17
Brooks AA, Johnson MR, Hills F, et al., 1995, Insulin-related growth factor binding protein-1 levels in ovum donation pregnancies., Eur J Obstet Gynecol Reprod Biol, Vol: 59, Pages: 91-94, ISSN: 0301-2115
The finding that endometrial maturation may be delayed following hormone replacement therapy has suggested that a generalised endometrial dysfunction may exist in ovum recipients. In order to investigate this suggestion further, circulating levels of IGFBP-1 were measured in samples taken throughout pregnancies conceived either spontaneously or following ovum donation. When analysed at two-weekly intervals, the serum levels of IGFBP-1 in ovum donation pregnancies failed to show the expected peak towards the end of the first trimester and were significantly reduced at week ten (U = 364.5, p = 0.0002) and twelve (U = 138.0, p = 0.0047). For the remainder of pregnancy, circulating IGFBP-1 levels were similar in both groups. The birth weight of children born to the ovum donation group was not significantly different from a normal control group, suggesting that circulating levels of IGFBP-1 in early pregnancy do not reflect local function and that IGFBP-1 does not have an essential function (in relation to birth weight) in early pregnancy.
ABBAS A, JOHNSON M, CHARD T, et al., 1995, MATERNAL PLASMA-CONCENTRATIONS OF INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-1 AND PLACENTAL PROTEIN-14 IN MULTIFETAL PREGNANCIES BEFORE AND AFTER FETAL REDUCTION, HUMAN REPRODUCTION, Vol: 10, Pages: 207-210, ISSN: 0268-1161
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- Citations: 12
Johnson MR, Jauniaux E, Ramsay B, et al., 1994, Maternal relaxin: a determinant of fetal heart rate?, Br J Obstet Gynaecol, Vol: 101, Pages: 1003-1004, ISSN: 0306-5456
Johnson MR, Abbas A, Nicolaides KH, 1994, Maternal plasma levels of human chorionic gonadotrophin, oestradiol and progesterone in multifetal pregnancies before and after fetal reduction., J Endocrinol, Vol: 143, Pages: 309-312, ISSN: 0022-0795
The aim of the study was to investigate the circulating levels of human chorionic gonadotrophin (hCG), oestradiol (OE2) and progesterone in multifetal pregnancies before and after embryo reduction. The levels of hCG, OE2 and progesterone were measured in plasma samples obtained from two groups of pregnant women: (i) singleton (n = 17), twin (n = 15) and triplet (n = 5) pregnancies achieved following superovulation; and (ii) multifetal pregnancies (three to ten embryos) undergoing fetal reduction to twin pregnancies (n = 31). The median value for each analyte at each gestational age in twin pregnancies was defined and used to derive multiples of the median (MoMs) for each analyte in samples obtained from multifetal pregnancies before and after reduction. The levels of hCG, OE2 and progesterone were significantly associated with the number of fetuses. Prior to reduction, the median MoMs for hCG, OE2 and progesterone were 1.54, 0.99 and 1.11 respectively. After reduction to twins the median MoMs decreased to 0.84 for hCG, 0.37 for progesterone and 0.51 for OE2. These data suggest that (i) the circulating levels of hCG, OE2 and progesterone increase with conceptus number; (ii) placental tissue does not remain active following fetal reduction; and (iii) the rate of steroid metabolism is increased in multiple pregnancy and remains elevated following fetal reduction.
JOHNSON MR, ABBAS AA, ALLMAN ACJ, et al., 1994, THE REGULATION OF PLASMA RELAXIN LEVELS DURING HUMAN-PREGNANCY, JOURNAL OF ENDOCRINOLOGY, Vol: 142, Pages: 261-265, ISSN: 0022-0795
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- Citations: 16
Johnson MR, Jauniaux E, Jurkovic D, et al., 1994, Relaxin concentrations in exoembryonic fluids during the first trimester., Hum Reprod, Vol: 9, Pages: 1561-1562, ISSN: 0268-1161
In 15 women undergoing therapeutic termination of pregnancy (8-13 weeks), the median concentration of relaxin was 1000 ng/l in maternal serum, 122 ng/l in coelomic fluid and 9 ng/l in amniotic fluid. Its presence in coelomic fluid suggests that relaxin may be present in the fetal circulation and thus be able to influence embryonic development during the period of organogenesis.
Morris NH, Johnson M, Steer P, et al., 1994, Upper abdominal pain in pregnancy. Measure blood pressure and analyse urine before admission., BMJ, Vol: 309, Pages: 270-271, ISSN: 0959-8138
Wookey S, 1994, Upper abdominal pain in pregnancy. Immediate admission is inappropriate., BMJ, Vol: 309, ISSN: 0959-8138
ABDALLA HI, BROOKS AA, JOHNSON MR, et al., 1994, ENDOMETRIAL THICKNESS - A PREDICTOR OF IMPLANTATION IN OVUM RECIPIENTS, HUMAN REPRODUCTION, Vol: 9, Pages: 363-365, ISSN: 0268-1161
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- Citations: 110
JOHNSON MR, ABBAS AA, IRVINE R, et al., 1994, REGULATION OF CORPUS-LUTEUM FUNCTION, HUMAN REPRODUCTION, Vol: 9, Pages: 41-48, ISSN: 0268-1161
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- Citations: 18
Johnson MR, Riddle AF, Grudzinskas JG, et al., 1993, Reduced circulating placental protein concentrations during the first trimester are associated with preterm labour and low birth weight., Hum Reprod, Vol: 8, Pages: 1942-1947, ISSN: 0268-1161
Serum concentrations of human chorionic gonadotrophin (HCG), Schwangerschaftsprotein 1 (SP-1), pregnancy-associated plasma protein A (PAPP-A), progesterone and oestradiol were measured at weekly intervals between the fifth (embryo transfer plus 3 weeks) and 13th week of gestation during the first trimester of pregnancies achieved following in-vitro fertilization (IVF) and embryo transfer in a group of women who delivered before (n = 8) or at term (n = 52). Those women who had a preterm delivery had significantly lower concentrations of PAPP-A (weeks 7-13; P = 0.0001-0.028) and SP-1 (weeks 6-8 and 10-12; P = 0.004-0.04). After correction of birth weight for sex and gestational age at delivery, preterm delivery was found not to be associated with growth retardation. However, comparison of the circulating concentrations of the substances analysed in mothers who delivered babies of < 85% of the 50th centile of the normal range of birth weight for a given gestational age and sex, with those who delivered babies of > 85% revealed that the concentrations of HCG (P = 0.012-0.04 on weeks 6-9) and SP-1 (P = 0.003-0.03 on weeks 7, 9-13) were significantly lower in the former group. Weak, inconsistent associations were found between the circulating concentrations of HCG, SP-1 and PAPP-A and both corrected birth weight and gestational age at delivery. Thus, both the gestational age at delivery and low birth weight may be related to impaired placental development/function during the first trimester.
JOHNSON M, 1993, THE ROLE OF TROPHOBLAST DYSFUNCTION IN THE ETIOLOGY OF MISCARRIAGE - REPLY, BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 100, Pages: 970-970, ISSN: 0306-5456
Johnson MR, Riddle AF, Irvine R, et al., 1993, Corpus luteum failure in ectopic pregnancy., Hum Reprod, Vol: 8, Pages: 1491-1495, ISSN: 0268-1161
The endocrinology of ectopic pregnancy was studied in order to investigate the origin of the discordance in the circulating amounts of human chorionic gonadotrophin (HCG) and those of oestradiol and progesterone. Serial maternal blood samples were obtained at 4-9 weeks gestation from 93 patients who became pregnant following in-vitro fertilization and embryo transfer including 10 ectopic, 21 anembryonic and 62 normal singleton pregnancies. The samples were analysed for HCG, Schwangerschaft protein-1 (SP-1), pregnancy-associated plasma protein-A (PAPP-A), progesterone and oestradiol. In ectopic pregnancies, concentrations of all substances analysed were significantly reduced compared to singleton pregnancies from 5 weeks gestation (P < 0.05-0.001) but they were not significantly different from those of anembryonic pregnancies. In ectopic pregnancies, associations were found between the concentration of both HCG and SP-1 and those of progesterone and oestradiol. No associations were found between PAPP-A and any other substances analysed. This may be due to insensitivity of the PAPP-A assay; alternatively PAPP-A concentrations may be differentially reduced in ectopic pregnancy. These findings suggest that progesterone and oestradiol are derived from the corpus luteum in early ectopic pregnancy but that the corpus luteum fails rapidly and the dominant source of both hormones becomes the trophoblast as early as 5 weeks.
JOHNSON MR, CARTER G, GRINT C, et al., 1993, RELATIONSHIP BETWEEN OVARIAN-STEROIDS, GONADOTROPINS AND RELAXIN DURING THE MENSTRUAL-CYCLE, ACTA ENDOCRINOLOGICA, Vol: 129, Pages: 121-125, ISSN: 0001-5598
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- Citations: 39
Johnson MR, Riddle AF, Grudzinskas JG, et al., 1993, The role of trophoblast dysfunction in the aetiology of miscarriage., Br J Obstet Gynaecol, Vol: 100, Pages: 353-359, ISSN: 0306-5456
OBJECTIVE: To investigate the endocrine changes associated with spontaneous miscarriage after fetal heart activity has been demonstrated. DESIGN: Prospective study during the first trimester of pregnancy comparing the circulating levels of human chorionic gonadotrophin (hCG), Schwangerschaft protein 1 (SP-1), pregnancy-associated plasma protein A (PAPP-A), oestradiol (E2), and progesterone (P), and fetal growth (crown-rump length [CRL] and gestational sac volume [GSV]) in women who miscarried after the identification of fetal heart activity with those of normal singleton and twin pregnancies achieved following in vitro fertilisation (IVF) and embryo transfer (ET). SETTING: The Assisted Conception Unit of King's College Hospital, London. SUBJECTS: Nine women who miscarried after demonstration of fetal heart activity, 52 normal singleton and 22 normal twin pregnancies. INTERVENTIONS: Weekly blood tests and ultrasound assessments of CRL and GSV. RESULTS: Four fetuses (all singleton) died between 9 and 12 weeks gestation (Group 1), and seven (three singleton and two twin) died between 16 and 20 weeks gestation (Group 2). In Group 1, both fetal growth and placental function, as assessed by serial measurements of CRL and GSV, and of serum levels of PAPP-A, SP-1 and hCG respectively, were reduced before fetal death. In Group 2, while fetal growth was maintained in all but one case, placental function was reduced in 4 of 5 women. CONCLUSION: These findings suggest that there may be a relationship between trophoblast dysfunction and some forms of miscarriage. Furthermore, the pattern of the reduction in the circulating levels of the placental proteins in later miscarriages suggests that the function of specific cell types may be impaired.
JOHNSON MR, ABBAS A, NORMANTAYLOR JQ, et al., 1993, CIRCULATING PLACENTAL PROTEIN 14 - IN THE 1ST TRIMESTER OF SPONTANEOUS AND IVF PREGNANCIES, HUMAN REPRODUCTION, Vol: 8, Pages: 323-326, ISSN: 0268-1161
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- Citations: 25
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