Imperial College London
Alternate

ProfessorMarkJohnson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Clinical Chair in Obstetrics
 
 
 
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Contact

 

+44 (0)20 3315 7887mark.johnson

 
 
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Location

 

H3.35Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cauldwell:2019:10.1111/1471-0528.15670,
author = {Cauldwell, M and Steer, PJ and Curtis, S and Mohan, AR and Dockree, S and Mackillop, L and Parry, H and Oliver, J and Sterrenburg, M and Bolger, A and Siddiqui, F and Simpson, M and Walker, N and Bredaki, F and Walker, F and Johnson, MR},
doi = {10.1111/1471-0528.15670},
journal = {BJOG: An International Journal of Obstetrics and Gynaecology},
pages = {1025--1031},
title = {Maternal and fetal outcomes in pregnancies complicated by the inherited aortopathy Loeys-Dietz syndrome},
url = {http://dx.doi.org/10.1111/1471-0528.15670},
volume = {126},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectivePregnancies in women with Loeys–Dietz syndrome (LDS) are rare and are typically documented in case reports only. Early reports suggested high rates of maternal complications during pregnancy and the puerperium, including aortic dissection and uterine rupture, but information on fetal outcomes was very limited.DesignA retrospective cohort study.SettingEight specialist UK centres.SamplePregnant women with LDS.MethodsData was collated on cardiac, obstetric, and neonatal outcomes.Main outcome measuresMaternal and perinatal outcomes in pregnancies complicated by LDS.ResultsTwenty pregnancies in 13 women with LDS were identified. There was one miscarriage, one termination of pregnancy, and 18 livebirths. In eight women the diagnosis was known prior to pregnancy but only one woman had preconception counselling. In four women the diagnosis was made during pregnancy through positive genotyping, and the other was diagnosed following delivery. Five women had a family history of aortic dissection. There were no aortic dissections in our cohort during pregnancy or postpartum. Obstetric complications were common, including postpartum haemorrhage (33%) and preterm delivery (50%). In all, 14/18 (78%) of deliveries were by elective caesarean section, at a median gestational age at delivery of 37 weeks. Over half the infants (56%) were admitted to the neonatal unit following delivery.ConclusionWomen with LDS require multidisciplinary specialist management throughout pregnancy. Women should be referred for preconception counselling to make informed decisions around pregnancy risk and outcomes. Early elective preterm delivery needs to be balanced against a high infant admission rate to the neonatal unit.
AU  - Cauldwell,M
AU  - Steer,PJ
AU  - Curtis,S
AU  - Mohan,AR
AU  - Dockree,S
AU  - Mackillop,L
AU  - Parry,H
AU  - Oliver,J
AU  - Sterrenburg,M
AU  - Bolger,A
AU  - Siddiqui,F
AU  - Simpson,M
AU  - Walker,N
AU  - Bredaki,F
AU  - Walker,F
AU  - Johnson,MR
DO  - 10.1111/1471-0528.15670
EP  - 1031
PY  - 2019///
SN  - 1470-0328
SP  - 1025
TI  - Maternal and fetal outcomes in pregnancies complicated by the inherited aortopathy Loeys-Dietz syndrome
T2  - BJOG: An International Journal of Obstetrics and Gynaecology
UR  - http://dx.doi.org/10.1111/1471-0528.15670
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000470936600019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/71388
VL  - 126
ER  -
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