Imperial College London
Alternate

ProfessorMarkJohnson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Clinical Chair in Obstetrics
 
 
 
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Contact

 

+44 (0)20 3315 7887mark.johnson

 
 
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Location

 

H3.35Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Singh:2019:biolre/ioz144,
author = {Singh, N and Herbert, B and Sooranna, G and Das, A and Sooranna, SR and Yellon, SM and Johnson, MR},
doi = {biolre/ioz144},
journal = {Biology of Reproduction},
pages = {1031--1045},
title = {Distinct preterm labor phenotypes have unique inflammatory signatures and contraction associated protein profiles},
url = {http://dx.doi.org/10.1093/biolre/ioz144},
volume = {101},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Preterm labor (PTL) is the predominant cause of childhood morbidity and mortality. It has several phenotypes, each with a distinct etiology often involving inflammation. Here, in samples of reproductive tissues obtained in early PTL from women with phenotypically defined PTL, we examined the presence and distribution of inflammation and its relationship with prolabor gene expression. In chorioamnionitis (CA-PTL), cytokine protein concentrations were increased across all tissues; in idiopathic (I-PTL), the inflammatory changes were limited to the choriodecidua; inflammation was not a feature of placental abruption (PA-PTL). CA-PTL was associated with activation of p65 in the myometrium and AP-1 in the choriodecidua, and PA-PTL with CREB in the choriodecidua. In the myometrium, PGHS-2 mRNA level was increased in CA- and I-PTL; in the amnion, PGHS-2 mRNA level was higher in PA- and I-PTL, while in CA-PTL, OT, OTR mRNA, and CX-43 expression were increased. In the choriodecidua, PGHS-2 mRNA level was unchanged, but in CA and I-PTL, OT mRNA level were increased and OTR was reduced. These data show that CA-PTL is associated with widespread inflammation and prolabor gene expression. In contrast, in I-PTL, inflammation is limited to the choriodecidua, with discrete increases in PGHS-2 in the amnion and OT in the choriodecidua. Inflammation is not a feature of PA-PTL, which is associated with increased OT and OTR in the amnion.
AU  - Singh,N
AU  - Herbert,B
AU  - Sooranna,G
AU  - Das,A
AU  - Sooranna,SR
AU  - Yellon,SM
AU  - Johnson,MR
DO  - biolre/ioz144
EP  - 1045
PY  - 2019///
SN  - 0006-3363
SP  - 1031
TI  - Distinct preterm labor phenotypes have unique inflammatory signatures and contraction associated protein profiles
T2  - Biology of Reproduction
UR  - http://dx.doi.org/10.1093/biolre/ioz144
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000509505000017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://academic.oup.com/biolreprod/article/101/5/1031/5549645
UR  - http://hdl.handle.net/10044/1/80162
VL  - 101
ER  -
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