Imperial College London
Alternate

ProfessorMarkJohnson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Clinical Chair in Obstetrics
 
 
 
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Contact

 

+44 (0)20 3315 7887mark.johnson

 
 
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Location

 

H3.35Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Shah:2019:10.1016/j.clim.2019.108254,
author = {Shah, NM and Imami, N and Kelleher, P and Barclay, WS and Johnson, MR},
doi = {10.1016/j.clim.2019.108254},
journal = {Clin Immunol},
title = {Pregnancy-related immune suppression leads to altered influenza vaccine recall responses.},
url = {http://dx.doi.org/10.1016/j.clim.2019.108254},
volume = {208},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Pregnancy is a risk factor for severe influenza infection. Despite achieving seroprotective antibody titres post immunisation fewer pregnant women experience a reduction in influenza-like illness compared to non-pregnant cohorts. This may be due to the effects that immune-modulation in pregnancy has on vaccine efficacy leading to a less favourable immunologic response. To understand this, we investigated the antigen-specific cellular responses and leukocyte phenotype in pregnant and non-pregnant women who achieved seroprotection post immunisation. We show that pregnancy is associated with better antigen-specific inflammatory (IFN-γ) responses and an expansion of central memory T cells (Tcm) post immunisation, but low-level pregnancy-related immune regulation (HLA-G, PIBF) and associated reduced B-cell antibody maintenance (TGF-β) suggest poor immunologic responses compared to the non-pregnant. Thus far, studies of influenza vaccine immunogenicity have focused on the induction of antibodies but understanding additional vaccine-related cellular responses is needed to fully appreciate how pregnancy impacts on vaccine effectiveness.
AU  - Shah,NM
AU  - Imami,N
AU  - Kelleher,P
AU  - Barclay,WS
AU  - Johnson,MR
DO  - 10.1016/j.clim.2019.108254
PY  - 2019///
TI  - Pregnancy-related immune suppression leads to altered influenza vaccine recall responses.
T2  - Clin Immunol
UR  - http://dx.doi.org/10.1016/j.clim.2019.108254
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31470087
UR  - http://hdl.handle.net/10044/1/74408
VL  - 208
ER  -
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