Imperial College London
Alternate

ProfessorMarkJohnson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Clinical Chair in Obstetrics
 
 
 
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Contact

 

+44 (0)20 3315 7887mark.johnson

 
 
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Location

 

H3.35Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rossi:2013:10.1007/s00330-012-2651-7,
author = {Rossi, A and van, der Linde D and Yap, SC and Lapinskas, T and Kirschbaum, S and Springeling, T and Witsenburg, M and Cuypers, J and Moelker, A and Krestin, GP and van, Dijk A and Johnson, M and van, Geuns R-J and Roos-Hesselink, JW},
doi = {10.1007/s00330-012-2651-7},
journal = {Eur Radiol},
pages = {642--649},
title = {Ascending aorta dilatation in patients with bicuspid aortic valve stenosis: a prospective CMR study.},
url = {http://dx.doi.org/10.1007/s00330-012-2651-7},
volume = {23},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: The aim of this study was to evaluate the natural progression of aortic dilatation and its association with aortic valve stenosis (AoS) in patients with bicuspid aortic valve (BAV). METHODS: Prospective study of aorta dilatation in patients with BAV and AoS using cardiac magnetic resonance (CMR). Aortic root, ascending aorta, aortic peak velocity, left ventricular systolic and diastolic function and mass were assessed at baseline and at 3-year follow-up. RESULTS: Of the 33 enrolled patients, 5 needed surgery, while 28 patients (17 male; mean age: 31 ± 8 years) completed the study. Aortic diameters significantly increased at the aortic annulus, sinus of Valsalva and tubular ascending aorta levels (P < 0.050). The number of patients with dilated tubular ascending aortas increased from 32 % to 43 %. No significant increase in sino-tubular junction diameter was observed. Aortic peak velocity, ejection fraction and myocardial mass significantly increased while the early/late filling ratio significantly decreased at follow-up (P < 0.050). The progression rate of the ascending aorta diameter correlated weakly with the aortic peak velocity at baseline (R (2) = 0.16, P = 0.040). CONCLUSION: BAV patients with AoS showed a progressive increase of aortic diameters with maximal expression at the level of the tubular ascending aorta. The progression of aortic dilatation correlated weakly with the severity of AoS.
AU  - Rossi,A
AU  - van,der Linde D
AU  - Yap,SC
AU  - Lapinskas,T
AU  - Kirschbaum,S
AU  - Springeling,T
AU  - Witsenburg,M
AU  - Cuypers,J
AU  - Moelker,A
AU  - Krestin,GP
AU  - van,Dijk A
AU  - Johnson,M
AU  - van,Geuns R-J
AU  - Roos-Hesselink,JW
DO  - 10.1007/s00330-012-2651-7
EP  - 649
PY  - 2013///
SP  - 642
TI  - Ascending aorta dilatation in patients with bicuspid aortic valve stenosis: a prospective CMR study.
T2  - Eur Radiol
UR  - http://dx.doi.org/10.1007/s00330-012-2651-7
UR  - https://www.ncbi.nlm.nih.gov/pubmed/23011212
VL  - 23
ER  -
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