Publications
300 results found
Owen DM, Manning HB, de Beule P, et al., 2007, Development of a hyperspectral fluorescence lifetime imaging microscope and its application to tissue imaging, Conference on Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X
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- Citations: 2
Soloviev VY, Tahir KB, McGinty J, et al., 2007, Fluorescence lifetime imaging through turbid media reconstructed in the Fourier domain using time-gated imaging data, Conference on Diffuse Optical Imaging of Tissue, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X
Manning HB, Owen DM, Auksorius E, et al., 2007, Applications of rapid time-gated hyperspectral FLIM: live cell imaging of membrane order and 6-D microscopy, Conference on Confocal, Multiphoton and Nonlinear Microscopic Imaging III, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X
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- Citations: 2
Benninger RKP, Hofmann O, Onfelt B, et al., 2007, Fluorescence-lifetime imaging of DNA-dye interactions within continuous-flow microfluidic systems, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 46, Pages: 2228-2231, ISSN: 1433-7851
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- Citations: 24
Owen D M, Manning H B, de Beule P, et al., 2007, Rapid hyperspectral fluorescence lifetime imaging, IMAGING, MANIPULATION AND ANALYSIS OF BIOMOLECULES, CELLS, AND TISSUES V, BIOS, Publisher: SPIE
Onfelt B, Nedvetzki S, Benninger RKP, et al., 2006, Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria, JOURNAL OF IMMUNOLOGY, Vol: 177, Pages: 8476-8483, ISSN: 0022-1767
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- Citations: 337
Boruah BR, Neil MAA, 2006, Susceptibility to and correction of azimuthal aberrations in singular light beams, OPTICS EXPRESS, Vol: 14, Pages: 10377-10385, ISSN: 1094-4087
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- Citations: 25
Zhang HX, Gu E, Jeon CW, et al., 2006, Microstripe-array InGaN light-emitting diodes with individually addressable elements, IEEE PHOTONICS TECHNOLOGY LETTERS, Vol: 18, Pages: 1681-1683, ISSN: 1041-1135
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- Citations: 18
Treanor B, Lanigan PMP, Kumar S, et al., 2006, Microclusters of inhibitory killer immunoglobulin like receptor signaling at natural killer cell immunological synapses, Journal of Cell Biology, Vol: 174, Pages: 153-161, ISSN: 1540-8140
We report the supramolecular organization of killer Ig–like receptor (KIR) phosphorylation using a technique applicable to imaging phosphorylation of any green fluorescent protein–tagged receptor at an intercellular contact or immune synapse. Specifically, we use fluorescence lifetime imaging (FLIM) to report Förster resonance energy transfer (FRET) between GFP-tagged KIR2DL1 and a Cy3-tagged generic anti-phosphotyrosine monoclonal antibody. Visualization of KIR phosphorylation in natural killer (NK) cells contacting target cells expressing cognate major histocompatibility complex class I proteins revealed that inhibitory signaling is spatially restricted to the immune synapse. This explains how NK cells respond appropriately when simultaneously surveying susceptible and resistant target cells. More surprising, phosphorylated KIR was confined to microclusters within the aggregate of KIR, contrary to an expected homogeneous distribution of KIR signaling across the immune synapse. Also, yellow fluorescent protein–tagged Lck, a kinase important for KIR phosphorylation, accumulated in a multifocal distribution at inhibitory synapses. Spatial confinement of receptor phosphorylation within the immune synapse may be critical to how activating and inhibitory signals are integrated in NK cells.
Owen DM, Lanigan PMP, Dunsby C, et al., 2006, Fluorescence lifetime imaging provides enhanced contrast when imaging the phase-sensitive dye di-4-ANEPPDHQ in model membranes and live cells, BIOPHYSICAL JOURNAL, Vol: 90, Pages: L80-L82, ISSN: 0006-3495
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- Citations: 110
Benninger RKP, Koç Y, Hofmann O, et al., 2006, Quantitative 3D mapping of fluidic temperatures within microchannel networks using fluorescence lifetime imaging, ANALYTICAL CHEMISTRY, Vol: 78, Pages: 2272-2278, ISSN: 0003-2700
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- Citations: 104
Galletly N, McGinty J, Munro I, et al., 2006, Fluorescence lifetime imaging of liver cancer, Digestive Disease Week/107th Annual Meeting of the American-Gastroenterological-Association, Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: A791-A791, ISSN: 0016-5085
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- Citations: 1
Galletly NP, McGinty JM, Cohen P, et al., 2006, Detection of gastrointestinal malignancy by fluorescence lifetime imaging of UV laser induced tissue autofluorescence, Annual Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A115-A115, ISSN: 0017-5749
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- Citations: 2
Galletly N, Mcginty JM, Cohen P, et al., 2006, Fluorescence Lifetime Imaging for Detection of Gastrointestinal Cancer, GASTROINTESTINAL ENDOSCOPY, Vol: 63, Pages: AB250-AB250, ISSN: 0016-5107
Lanigan PMP, Dunsby C, McGinty J, et al., 2006, An electronically tunable ultrafast laser source applied to fluorescence imaging and fluorescence lifetime imaging microscopy
We demonstrate that spectral selection from a supercontinuum generated in a microstructured fibre can provide a continuously electronically tunable ultrafast spatially coherent source for confocal microscopy and both scanning and wide field fluorescence lifetime imaging. © 2005 Optical Society of America.
Wilson T, Massoumian F, Juskaitis R, et al., 2006, Quantitative Polarised Light Microscopy, MULTI-MODALITY MICROSCOPY, Editors: Yu, Cheng, Lin, Kao, Publisher: WORLD SCIENTIFIC PUBL CO PTE LTD, Pages: 150-161
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- Citations: 1
Kennedy, Gordon T, Elson, et al., 2006, Fluorescence Lifetime Imaging Using Light Emitting Diodes, Photon 06, Publisher: Institute of Physics
Grant DM, Elson DS, Schimpf D, et al., 2005, Optically sectioned fluorescence lifetime imaging using a Nipkow disk microscope and a tunable ultrafast continuum excitation source, OPTICS LETTERS, Vol: 30, Pages: 3353-3355, ISSN: 0146-9592
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- Citations: 31
Munro I, McGinty J, Galletly N, et al., 2005, Toward the clinical application of time-domain fluorescence lifetime imaging, JOURNAL OF BIOMEDICAL OPTICS, Vol: 10, ISSN: 1083-3668
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- Citations: 54
Benninger RKP, Hofmann O, McGinty J, et al., 2005, Time-resolved fluorescence imaging of solvent interactions in microfluidic devices, OPTICS EXPRESS, Vol: 13, Pages: 6275-6285, ISSN: 1094-4087
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- Citations: 46
Benninger RKP, McGinty J, Hofmann O, et al., 2005, Application of multi-dimensional fluorescence imaging to microfluidic devices, European Conference on Lasers and Electro-Optics
Talbot CB, Benninger RKP, De Beule P, et al., 2005, Application of fluorescence lifetime and hyperspectral imaging to tissue autofluorescence: Arthritis
We present the application of fluorescence lifetime imaging (FLIM) and hyperspectral FLIM to autofluorescence of normal and arthritic cartilage tissue. ©2005 Optical Society of America.
Lanigan PMP, Dunsby C, McGinty J, et al., 2005, An electronically tunable ultrafast laser source applied to fluorescence imaging and fluorescence lifetime imaging microscopy, Washington, CONFERENCE ON LASERS & ELECTRO-OPTICS (CLEO), Publisher: Optical Society of America, Pages: 1366-1368
Dunsby C, Lanigan PMP, McGinty J, et al., 2005, An electronically tunable ultrafast laser source applied to fluorescence imaging and microscopy including fluorescence lifetime imaging
Benninger RKP, Hofmann O, McGinty J, et al., 2005, 3D high-speed time-resolved fluorescence imaging of solvent interactions in microfluidic devices, Pages: 16-18
This paper reports on the application of novel wide-field time-resolved fluorescence imaging methods to monitor solvent interactions and mixing in microfluidic devices. Time-resolved fluorescence anisotropy imaging (TR-FAIM) is employed for 3D viscosity mapping with sub-micron resolution. To image dynamic fluid mixing in real-time, we demonstrate high-speed fluorescence lifetime imaging (FLIM) at video acquisition rates. Copyright © 2005 by the Transducer Research Foundation, Inc.
Lanigan PMP, Dunsby C, McGinty J, et al., 2005, An electronically tunable ultrafast laser source applied to fluorescence imaging and fluorescence lifetime imaging microscopy, Pages: 1366-1368
We demonstrate that spectral selection from a supercontinuum generated in a microstructured fibre can provide a continuously electronically tunable ultrafast spatially coherent source for confocal microscopy and both scanning and wide field fluorescence lifetime imaging. © 2005 Optical Society of America.
Önfelt B, Benninger RKP, Nedvetzki S, et al., 2005, Probing intercellular communication across membrane nanotubes and immunological Synapses, 49th Annual Meeting of the Biopysical-Society, Publisher: BIOPHYSICAL SOCIETY, Pages: 431A-431A, ISSN: 0006-3495
Benninger RKP, Onfelt B, Neil MAA, et al., 2005, Imaging lipid structure with fluorescence-detected 2-photon linear dichroism, 49th Annual Meeting of the Biopysical-Society, Publisher: BIOPHYSICAL SOCIETY, Pages: 69A-69A, ISSN: 0006-3495
Treanor B, Lanigan PMP, Suhling K, et al., 2005, Imaging fluorescence lifetime heterogeneity applied to GFP-tagged MHC protein at an immunological synapse, JOURNAL OF MICROSCOPY-OXFORD, Vol: 217, Pages: 36-43, ISSN: 0022-2720
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- Citations: 53
Benninger RKP, Önfelt B, Neil MAA, et al., 2005, Fluorescence imaging of two-photon linear dichroism:: Cholesterol depletion disrupts molecular orientation in cell membranes, BIOPHYSICAL JOURNAL, Vol: 88, Pages: 609-622, ISSN: 0006-3495
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- Citations: 62
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