Imperial College London

DrMarkUngless

Faculty of MedicineInstitute of Clinical Sciences

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 8299mark.ungless

 
 
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Location

 

2006CRB (Clinical Research Building)Hammersmith Campus

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Summary

 

Summary

The aim of our research is to understand the key principles underlying the anatomy and physiology of midbrain dopamine neurons


 

Dopamine neurons have a central role in processing rewards and punishments. Despite only numbering several hundred thousand, dopamine neurons have a powerful influence on the normal functioning of the brain through their dense axonal projections to many other brain regions involved in motivated behaviour, learning and memory, attention and movement. Dopamine neuron dysfunction is implicated in several disorders, including Parkinson’s disease, schizophrenia and addiction.

We are currently focused on studying the anatomical and functional diversity of subgroups of dopamine neurons and how their activity is controlled by GABAergic inhibitory neurons. To address this we are using in vivo and in vitro electrophysiological techniques, including optogenetics, combined with single-cell labelling, neuroanatomical, molecular and behavioural approaches.

UnglessResearchImage

 

Figure: a) Spontaneous in vivo extracellular action potential activity in a ventral tegmental area dopamine neuron. b) DIC image of a whole-cell recording from a substantia nigra pars compacta dopamine neuron with overlaid electrophysiological trace of inhibitory synaptic currents. c) Immunostaining for tyrosine hydroxylase (red) in the dorsal raphe nucleus (DRN) and GFP (green) driven by the Pitx3 promoter.

Selected Publications

Journal Articles

Matthews GA, Nieh EH, Vander Weele CM, et al., 2016, Dorsal Raphe Dopamine Neurons Represent the Experience of Social Isolation, Cell, Vol:164, ISSN:0092-8674, Pages:617-631

Winton-Brown TT, Fusar-Poli P, Ungless MA, et al., 2014, Dopaminergic basis of salience dysregulation in psychosis, Trends in Neurosciences, Vol:37, ISSN:0166-2236, Pages:85-94

Virdee K, McArthur S, Brischoux F, et al., 2014, Antenatal Glucocorticoid Treatment Induces Adaptations in Adult Midbrain Dopamine Neurons, which Underpin Sexually Dimorphic Behavioral Resilience, Neuropsychopharmacology, Vol:39, ISSN:0893-133X, Pages:339-350

Brischoux F, Chakraborty S, Brierley DI, et al., 2009, Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli, Proceedings of the National Academy of Sciences of the United States of America, Vol:106, ISSN:0027-8424, Pages:4894-4899

More Publications