Imperial College London
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Professor Mark Rehkämper

Faculty of Engineering, Department of Earth Science & Engineering

Professor of Isotope Geochemistry
 
 
 
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Contact

 

markrehk Website

 
 
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Location

 

451Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Larner:2015:10.1039/c4mt00260a,
author = {Larner, F and Woodley, LN and Shousha, S and Moyes, A and Humphreys-Williams, E and Strekopytov, S and Halliday, AN and Rehkaemper, M and Coombes, RC},
doi = {10.1039/c4mt00260a},
journal = {Metallomics: integrated biometal science},
pages = {107--112},
title = {Zinc isotopic compositions of breast cancer tissue},
url = {http://dx.doi.org/10.1039/c4mt00260a},
volume = {7},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - An early diagnostic biomarker for breast cancer is essential to improve outcome. High precision isotopic analysis, originating in Earth sciences, can detect very small shifts in metal pathways. For the first time, the natural intrinsic Zn isotopic compositions of various tissues in breast cancer patients and controls were determined. Breast cancer tumours were found to have a significantly lighter Zn isotopic composition than the blood, serum and healthy breast tissue in both groups. The Zn isotopic lightness in tumours suggests that sulphur rich metallothionein dominates the isotopic selectivity of a breast tissue cell, rather than Zn-specific proteins. This reveals a possible mechanism of Zn delivery to Zn-sequestering vesicles by metallothionein, and is supported by a similar signature observed in the copper isotopic compositions of one breast cancer patient. This change in intrinsic isotopic compositions due to cancer has the potential to provide a novel early biomarker for breast cancer.
AU  - Larner,F
AU  - Woodley,LN
AU  - Shousha,S
AU  - Moyes,A
AU  - Humphreys-Williams,E
AU  - Strekopytov,S
AU  - Halliday,AN
AU  - Rehkaemper,M
AU  - Coombes,RC
DO  - 10.1039/c4mt00260a
EP  - 112
PY  - 2015///
SN  - 1756-5901
SP  - 107
TI  - Zinc isotopic compositions of breast cancer tissue
T2  - Metallomics: integrated biometal science
UR  - http://dx.doi.org/10.1039/c4mt00260a
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000346899100011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/19502
VL  - 7
ER  -
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