Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Visiting Professor



+44 (0)20 8725 5959mary.sheppard








Professor Sheppard is honoury Professor of Cardiovascular Pathology at the National Heart and Lung Institute, Imperial College London, and has worked there for 25 years. She is now head of the Cardiovascular Pathology Unit at St George’s Medical School which is a unique academic centre within UK funded by Charity, Cardiac Risk in the Young (CRY). Professor Sheppard has built up an extensive network with her cardiological colleagues within Royal Brompton hospital and St Georges Hospital. She  collaborates on imaging with MRI unit of Royal Brompton Hospital and BRU Cardiovascular Unit within Imperial with an emphasis on cardiac genetics with Professor Stuart Cook. 

Prof Sheppard can be contacted at

She is an expert cardiovascular pathologist and has established a unique international cardiac referral centre to investigate sudden young cardiac deaths. She has established a national database on sudden cardiac death with the Coroner’s Society based at St Georges medical School. She qualified in medicine from University College Cork in Ireland. Professor Sheppard won a Wellcome fellowship and completed her research MD at the Royal Postgraduate Medical School, London. She completed specialist training in Histopathology at University College Hospital London.  She was appointed  as a specialist cardiothoracic pathologist at Royal Brompton Hospital in London and was trained in cardiac pathology by Professor Michal Davies and in cardiac anatomy by Professor Robert Anderson. She did post graduate studies with a Fogarthy postgraduate Fellowship to NIH Washington DC and Armed Forces Institute of Pathology, Washington DC. Since her appointment  at St George’s,  she has  established her working  laboratory with technical, medical and administrative staff.   She lectures both nationally and internationally on cardiac pathology. She has been appointed as national trainer in  cardiovascular pathology for forensic and general pathology trainees in UK.

She has published 200 peer reviewed papers, 71 case reports, 24 book chapters, 36 reviews/letters/articles, 9 international guidelines/government reports. In addition she has co co authored four books including cardiac pathology and imaging, pulmonary pathology and cardiac valve disease and has completed the second edition of her book on Cardiovascular Pathology. She was the Cardiovascular Pathology representative on the specialist advisory committee of Royal College of Pathologists. She has co-written the guidelines on the investigation of sudden cardiac death issued by Royal College of Pathologists. She is a member of the Editorial Board and subeditor (cardiac pathology) for Histopathology and Editorial board member of Cardiovascular Pathology. She is past President of the Pathology Section of the Royal Society of Medicine.  She is President Elect of European Association of cardiovascular pathology. She is also on committee developing international guidelines in training in cardiovascular pathology. Professor Sheppard was awarded the Stokes Medal for her work by the Irish Cardiovascular Society in 2009 and gave the Phillip Poole Wilson memorial lecture in London in October 2014.

Selected Publications

Journal Articles

Bowker TJ, Wood DA, Davies MJ, et al., 2003, Sudden, unexpected cardiac or unexplained death in England: a national survey, Qjm, Vol:96, Pages:269-279

Fabre A, Sheppard MN, 2005, Sudden adult death syndrome and other non ischaemic causes of sudden cardiac death: a UK experience, Heart, Vol:1, Pages:1031-1035

Whyte GP, Sheppard MN, George KP, et al., 2007, Arrhythmias and the athlete: mechanisms and clinical significance, European Heart Journal, Pages:1399-1400

de Noronha SV, Sharma S, Papadakis M, et al., 2009, Aetiology of sudden cardiac death in athletes in the United Kingdom: a pathological study, Heart, Vol:17, Pages:1409-1414

Papadakis M, Sharma S, Cos S, et al., 2009, The magnitude of sudden cardiac death in the young: a death certificate-based review in England and Wales, European Society of Cardiology, Vol:10, Pages:1353-1358

Patel J, Melly L, Sheppard MN, 2010, Primary cardiac lymphoma: B- and T-cell cases at a specialist UK centre, Annals of Oncology, Vol:21, ISSN:0923-7534, Pages:1041-1045

Basso C, Burke M, Fornes P, et al., 2008, Guidelines for autopsy investigation of sudden cardiac death, Virchows Archive, Vol:1

Thiene G, Veinot JP, Angelini A, et al., 2010, AECVP and SCVP 2009 Recommendations for Training in cardiovascular Pathology., Cardiovascular Pathology

Sheppard MNEA, 2010, Guidelines for Endomyocardial Biopsies, Cardiovascular Pathology

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