Imperial College London
Alternate

ProfessorMatthewPickering

Faculty of Medicine, Department of Immunology and Inflammation

Centre Director, Professor of Rheumatology
 
 
 
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Contact

 

matthew.pickering Website

 
 
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Assistant

 

Miss Claudia Rocchi +44 (0)20 3313 2315

 
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Location

 

9N12Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Foschi:2019:10.1177/0961203319860582,
author = {Foschi, V and Bortolotti, D and Doyle, AF and Stratigou, V and Stephens, L and Trivedi, P and Rinaldi, R and Padovan, M and Bortoluzzi, A and Lightstone, L and Cairns, TD and Botto, M and Cook, TH and Rizzo, R and Govoni, M and Pickering, MC},
doi = {10.1177/0961203319860582},
journal = {Lupus},
pages = {1091--1100},
title = {Analysis of HLA-G expression in renal tissue in lupus nephritis: a pilot study},
url = {http://dx.doi.org/10.1177/0961203319860582},
volume = {28},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: The study aimed to investigate whether HLA-G antigen is expressed in the kidneys of patients affected by lupus nephritis (LN) and whether its detection in renal biopsies could be adopted as a marker of treatment response and prognosis. METHODS: Thirty renal biopsies from patients with LN were selected and analyzed through immunohistochemistry. Laboratory and clinical data were retrospectively collected at baseline, 6 and 12 months and at the latest clinical appointment. A number of patients (63.3%) were treated with rituximab (RTX) +/- methylprednisolone in the induction phase. The expression of HLA-G in glomeruli, tubules and infiltrating cells was examined and compared between lupus patients who achieved either complete or partial renal response and those who did not respond to treatment. RESULTS: HLA-G staining was observed in the glomeruli of 20 of 30 samples from patients with LN. The expression of the antigen was detected in podocytes, along glomerular capillary walls, on parietal glomerular epithelial cells and within the juxtaglomerular apparatus. Seventy per cent of patients whose glomeruli expressed HLA-G achieved partial or complete response at 6 months and 75% at the latest available follow up compared with 30% and 40%, respectively, of those who did not show any expression. The pattern of staining in tubules and infiltrating cells was highly variable precluding any clinical correlation. CONCLUSION: This study demonstrates that HLA-G is expressed in renal tissue in LN. Our retrospective data suggest that its expression could correlate with response to treatment.
AU  - Foschi,V
AU  - Bortolotti,D
AU  - Doyle,AF
AU  - Stratigou,V
AU  - Stephens,L
AU  - Trivedi,P
AU  - Rinaldi,R
AU  - Padovan,M
AU  - Bortoluzzi,A
AU  - Lightstone,L
AU  - Cairns,TD
AU  - Botto,M
AU  - Cook,TH
AU  - Rizzo,R
AU  - Govoni,M
AU  - Pickering,MC
DO  - 10.1177/0961203319860582
EP  - 1100
PY  - 2019///
SN  - 1477-0962
SP  - 1091
TI  - Analysis of HLA-G expression in renal tissue in lupus nephritis: a pilot study
T2  - Lupus
UR  - http://dx.doi.org/10.1177/0961203319860582
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31291846
UR  - https://journals.sagepub.com/doi/10.1177/0961203319860582
UR  - http://hdl.handle.net/10044/1/71466
VL  - 28
ER  -
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