Imperial College London
Alternate

ProfessorMatthewPickering

Faculty of Medicine, Department of Immunology and Inflammation

Centre Director, Professor of Rheumatology
 
 
 
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Contact

 

matthew.pickering Website

 
 
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Assistant

 

Miss Claudia Rocchi +44 (0)20 3313 2315

 
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Location

 

9N12Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tortajada:2019:10.1016/j.molimm.2019.07.017,
author = {Tortajada, A and Gutierrez, E and Pickering, MC and Praga, Terente M and Medjeral-Thomas, N},
doi = {10.1016/j.molimm.2019.07.017},
journal = {Molecular Immunology},
pages = {123--132},
title = {The role of complement in IgA nephropathy},
url = {http://dx.doi.org/10.1016/j.molimm.2019.07.017},
volume = {114},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - IgA nephropathy (IgAN) is common and often progresses to end stage renal disease. IgAN encompasses a wide range of histology and clinical features. IgAN pathogenesis is incompletely understood; the current multi-hit hypothesis of IgAN pathogenesis does not explain the range of glomerular inflammation and renal injury associated with mesangial IgA deposition. Although associations between IgAN and glomerular and circulating markers of complement activation are established, the mechanism of complement activation and contribution to glomerular inflammation and injury are not defined. Recent identification of specific complement pathways and proteins in severe IgAN cases had advanced our understanding of complement in IgAN pathogenesis. In particular, a growing body of evidence implicates the complement factor H related proteins 1 and 5 and lectin pathway as pathogenic in a subset of patients with severe disease. These data suggest complement deregulation and activity may be dominant drivers of renal injury in IgAN. Thereby, markers of complement activation may identify IgAN patients likely to progress to significant renal impairment and complement inhibition may emerge as an effective method of preventing and reducing glomerular injury in IgAN.
AU  - Tortajada,A
AU  - Gutierrez,E
AU  - Pickering,MC
AU  - Praga,Terente M
AU  - Medjeral-Thomas,N
DO  - 10.1016/j.molimm.2019.07.017
EP  - 132
PY  - 2019///
SN  - 0161-5890
SP  - 123
TI  - The role of complement in IgA nephropathy
T2  - Molecular Immunology
UR  - http://dx.doi.org/10.1016/j.molimm.2019.07.017
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31351413
UR  - http://hdl.handle.net/10044/1/74020
VL  - 114
ER  -
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