Imperial College London
Alternate

ProfessorMatthewPickering

Faculty of Medicine, Department of Immunology and Inflammation

Centre Director, Professor of Rheumatology
 
 
 
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Contact

 

matthew.pickering Website

 
 
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Assistant

 

Miss Claudia Rocchi +44 (0)20 3313 2315

 
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Location

 

9N12Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{van:2016:infdis/jiw029,
author = {van, der Maten E and Westra, D and van, Selm S and Langereis, JD and Bootsma, HJ and van, Opzeeland FJ and de, Groot R and Ruseva, MM and Pickering, MC and van, den Heuvel LP and van, de Kar NC and de, Jonge MI and van, der Flier M},
doi = {infdis/jiw029},
journal = {Journal of Infectious Diseases},
pages = {1820--1827},
title = {Complement factor H serum levels determine resistance to pneumococcal invasive disease},
url = {http://dx.doi.org/10.1093/infdis/jiw029},
volume = {213},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Streptococcus pneumoniae is a major cause of life-threatening infections. Complement activation plays a vital role in opsonophagocytic killing of pneumococci in blood. Initial complement activation via the classical and lectin pathways is amplified through the alternative pathway amplification loop. Alternative pathway activity is inhibited by complement factor H (FH). Our study demonstrates the functional consequences of the variability in human serum FH levels on host defense. Using an in vivo mouse model combined with human in vitro assays, we show that the level of serum FH correlates with the efficacy of opsonophagocytic killing of pneumococci. In summary, we found that FH levels determine a delicate balance of alternative pathway activity, thus affecting the resistance to invasive pneumococcal disease. Our results suggest that variation in FH expression levels, naturally occurring in the human population, plays a thus far unrecognized role in the resistance to invasive pneumococcal disease.
AU  - van,der Maten E
AU  - Westra,D
AU  - van,Selm S
AU  - Langereis,JD
AU  - Bootsma,HJ
AU  - van,Opzeeland FJ
AU  - de,Groot R
AU  - Ruseva,MM
AU  - Pickering,MC
AU  - van,den Heuvel LP
AU  - van,de Kar NC
AU  - de,Jonge MI
AU  - van,der Flier M
DO  - infdis/jiw029
EP  - 1827
PY  - 2016///
SN  - 1537-6613
SP  - 1820
TI  - Complement factor H serum levels determine resistance to pneumococcal invasive disease
T2  - Journal of Infectious Diseases
UR  - http://dx.doi.org/10.1093/infdis/jiw029
UR  - http://hdl.handle.net/10044/1/33417
VL  - 213
ER  -
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