Imperial College London
Alternate

ProfessorMatthewPickering

Faculty of Medicine, Department of Immunology and Inflammation

Centre Director, Professor of Rheumatology
 
 
 
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Contact

 

matthew.pickering Website

 
 
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Assistant

 

Miss Claudia Rocchi +44 (0)20 3313 2315

 
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Location

 

9N12Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Medjeral-Thomas:2018:10.1016/j.ekir.2017.11.015,
author = {Medjeral-Thomas, NR and Troldborg, A and Constantinou, N and Lomax-Browne, HJ and Hansen, AG and Willicombe, M and Pusey, CD and Cook, HT and Thiel, S and Pickering, MC},
doi = {10.1016/j.ekir.2017.11.015},
journal = {KIDNEY INTERNATIONAL REPORTS},
pages = {426--438},
title = {Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin-Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H-Related Protein-5 (FHR5) Deposition},
url = {http://dx.doi.org/10.1016/j.ekir.2017.11.015},
volume = {3},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - IntroductionIgA nephropathy (IgAN) is characterized by glomerular deposition of galactose-deficient IgA1 and complement proteins and leads to renal impairment. Complement deposition through the alternative and lectin activation pathways is associated with renal injury.MethodsTo elucidate the contribution of the lectin pathway to IgAN, we measured the 11 plasma lectin pathway components in a well-characterized cohort of patients with IgAN.ResultsM-ficolin, L-ficolin, mannan-binding lectin (MBL)–associated serine protease (MASP)-1 and MBL-associated protein (MAp) 19 were increased, whereas plasma MASP-3 levels were decreased in patients with IgAN compared with healthy controls. Progressive disease was associated with low plasma MASP-3 levels and increased glomerular staining for C3b/iC3b/C3c, C3d, C4d, C5b-9, and factor H–related protein 5 (FHR5). Glomerular FHR5 deposition positively correlated with glomerular C3b/iC3b/C3c, C3d, and C5b-9 deposition, but not with glomerular C4d. These observations, together with the finding that glomerular factor H (fH) deposition was reduced in progressive disease, are consistent with a role for fH deregulation by FHR5 in renal injury in IgAN.ConclusionOur data indicate that circulating MASP-3 levels could be used as a biomarker of disease severity in IgAN and that glomerular staining for FHR5 could both indicate alternative complement pathway activation and be a tissue marker of disease severity.
AU  - Medjeral-Thomas,NR
AU  - Troldborg,A
AU  - Constantinou,N
AU  - Lomax-Browne,HJ
AU  - Hansen,AG
AU  - Willicombe,M
AU  - Pusey,CD
AU  - Cook,HT
AU  - Thiel,S
AU  - Pickering,MC
DO  - 10.1016/j.ekir.2017.11.015
EP  - 438
PY  - 2018///
SN  - 2468-0249
SP  - 426
TI  - Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin-Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H-Related Protein-5 (FHR5) Deposition
T2  - KIDNEY INTERNATIONAL REPORTS
UR  - http://dx.doi.org/10.1016/j.ekir.2017.11.015
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000427638100024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/59364
VL  - 3
ER  -
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