I lead the Computational Oncology group at Imperial College, based jointly between the Dept. of Computing and Division of Surgery & Cancer.
We are interested in mathematical and computational approaches to clinical problems, including the use of machine learning, computational argumentation and the use of clinical 'big data'. In particular, we are interested in improving access to and use of clinical data, with the aim of developing and applying computational techniques to these data. We also work on using computational techniques to reason with clinical trial data. Our current work covers a range of areas, including novel techniques for systemic reviews and evidence aggregation and mathematical modelling of prognosis in patients receiving palliative chemotherapy. We have begun to collect this work under the banner of computational oncology - see here for more details, and here for details of our recent conference.
I have several local & national positions working with cancer data to understand and improve cancer care in the UK and beyond, including NCRAS and Macmillan.
Clinically, I deliver radiotherapy and chemotherapy to patient with brain and spinal tumours, including IMRT and stereotactic radiotherapy. My clinical work is based at Charing Cross hospital, although I also visit Northwick Park and Mount Vernon hospitals weekly. At Charing Cross we have an excellent multi-disciplinary team of surgeons, radiologists, nurses, oncologists and others who provide diagnostic and treatment services across, and beyond, north-west London, with some of the best brain tumour outcomes in the country.
My clinical research into patterns of care and outcomes in patients with a wide range of tumours, and developing better ways of assessing patient outcomes. This is increasingly focused around brain tumours, and I am the PI on a national patterns of care study in high-grade glioma.
et al., 2017, Estimating progression-free survival in patients with glioblastoma using routinely collected data, Journal of Neuro-oncology, Vol:135, ISSN:0167-594X, Pages:621-627
et al., 2017, Postprogression survival in patients with glioblastoma treated with concurrent chemoradiotherapy: a routine care cohort study, Cns Oncology, ISSN:2045-0907
et al., 2016, Surgeon volume and 30 day mortality for brain tumours in England, British Journal of Cancer, Vol:115, ISSN:0007-0920, Pages:1379-1382
et al., 2016, Online Argumentation-Based Platform for Recommending Medical Literature, 4th International Workshop on Combinations of Intelligent Methods and Applications (CIMA), SPRINGER-VERLAG BERLIN, Pages:97-115, ISSN:2190-3018