215 results found
Boily MC, Bastos FI, Desai K, et al., 2005, Increasing prevalence of male homosexual partnerships and practices in Britain 1990-2000: but why?, AIDS, Vol: 19, Pages: 352-354, ISSN: 0269-9370
Boily MC, Godin G, Hogben M, et al., 2005, The impact of the transmission dynamics of the HIV/AIDS epidemic on sexual behaviour: A new hypothesis to explain recent increases in risk taking-behaviour among men who have sex with men, MEDICAL HYPOTHESES, Vol: 65, Pages: 215-226, ISSN: 0306-9877
Boily M-C, Hogben M, Sherr L, et al., 2005, The impact of the transmission dynamics of the HIV/AIDS epidemic on sexual behaviour: A new hypothesis to explain recent increases in risk taking-behaviour among men who have sex with men., Medical Hypotheses, Vol: 65(2), Pages: 215-216
Paz-Bailey G, Rahman M, Chen C, et al., 2005, Changes in the etiology of sexually transmitted diseases in Botswana between 1993 and 2002: implications for the clinical management of genital ulcer disease, Clin Infect Dis., Vol: 41, Pages: 1304-1312, ISSN: 1058-4838
Boily MC, Bastos FI, Desai K, et al., 2004, Changes in the transmission dynamics of the HIV epidemic after the wide-scale use of antiretroviral therapy could explain increases in sexually transmitted infections - Results from mathematical models, SEXUALLY TRANSMITTED DISEASES, Vol: 31, Pages: 100-112, ISSN: 0148-5717
Boily MC, White RG, Alary M, et al., 2004, Transmission of HIV via unsafe injection or unsafe sex? Anomalies or misunderstanding?, INTERNATIONAL JOURNAL OF STD & AIDS, Vol: 15, Pages: 61-63, ISSN: 0956-4624
Bastos FI, Petersen M, Kerrigan D, et al., 2004, La prise en charge des traitements contre le VIH/SIDA. L’esperience bresilienne., Les Antirétroviraux: Expériences et Défis, Editors: Levy, Pierret, Trottier, Publisher: Les Presses de l’Université du Québec, Pages: 195-236
Alary M, Lowndes CM, Boily MC, 2003, Community randomized trials for HIV prevention: The past, a lesson for the future?, AIDS, Vol: 17, Pages: 2661-2663, ISSN: 0269-9370
Alary M, Lowndes CA, Boily MC, 2003, Community randomized trials for HIV prevention: the past, a lesson for the future?, AIDS, Vol: 17, Pages: 2661-2663, ISSN: 0269-9370
Desai K, Boily MC, Garnett GP, et al., 2003, The use of mathematical modeling ot validate statistical power and protective efficacy of circumcision against HIV and STI in a current phase III study in Kisumu, Kenya, 3rd Joint International Conference of ISCB and SCT
Raboud JM, Boily MC, Rajeswaran J, et al., 2003, The impact of needle-exchange programs on the spread of HIV among injection drug users: a simulation study, Conference on Statistics and Health, Publisher: SPRINGER, Pages: 302-320, ISSN: 1099-3460
Boily MC, Desai K, Masse BR, et al., 2003, The use of transmission dynamics models of infectious diseases to improve clinical trials and public health decisions, . 9th Biennial Symposium on Statistical Methods in Atlanta
Boily M-C, White R, Lowndes C, et al., 2003, Transmission of HIV via unsafe injection or unsafe sex? Anomalies or misunderstanding?, Int J of STD&AIDS, Vol: 15, Pages: 61-62
Ghani A, Boily M-C, 2003, The epidemiology of HIV/AIDS: Contributions to infectious diseases epidemiology, LEarning from HIV and AIDS, Editors: Ellison, Parker, Campbell, Publisher: Cambridge University Press, Pages: 59-87
Boily MC, Bastos FI, Masse B, 2002, No increase in HIV incidence in a cohort of men who have sex with men in Montreal: too early to conclude?, AIDS, Vol: 16, Pages: 2502-2503, ISSN: 0269-9370
Boily MC, Lowndes CM, Gregson S, 2002, Population-level risk factors for HIV transmission and 'the 4 Cities Study': temporal dynamics and the significance of sexual mixing patterns, AIDS, Vol: 16, Pages: 2101-2102, ISSN: 0269-9370
Boily MC, Lowndes C, Alary M, 2002, The impact of HIV epidemic phases on the effectiveness of core group interventions: insights from mathematical models., Pages: i78-i90, ISSN: 1368-4973
Mathematical models have highlighted the disproportionate contribution of core group transmitters to the spread of sexually transmitted diseases. Because the effectiveness of interventions varies with time, it has been suggested that epidemic phases should be considered in the design of prevention strategies. This study aimed to examine the impact of HIV epidemic phases on the effectiveness of HIV interventions based on gonorrhoea screening and condom use, targeted to core groups. The results are based on a mathematical model of gonorrhoea and HIV transmission in a relatively slow spreading HIV epidemic using Cotonou (Benin) as an example. For epidemics with a low reproductive potential modest core group interventions can significantly reduce HIV incidence and prevalence. As the epidemic matures, effective interventions should also incorporate core and non-core populations. For epidemics with a high reproductive potential, core group interventions are necessary but not sufficient to have a rapid and large scale impact. A more general population approach is also needed early in the epidemic. Epidemic phases are also important in the evaluation of prevention strategies.
poulin C, ALARY M, Bernier F, et al., 2001, Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae Among At-Risk Women, Young Sex Workers, and Street Youth Attending Community Organizations in Quebec City, Canada, Sexually Transmitted Diseases:, Vol: 28, Pages: 437-443
Background: Despite a relatively recent decline in the global incidence of Chlamydia trachomatis and Neisseria gonorrhoeae it seems that some segments of the population such as street youth, sex workers, and individuals with social problems or delinquent behavior could be part of a core group for STDs. These persons may be reluctant to undergo STD diagnosis in traditional medical settings.Goals: To determine the prevalence of C trachomatis and N gonorrhoeae infection using polymerase chain reaction on urine samples among subjects attending an anonymous HIV testing clinic and four community organizations in Quebec City, and to identify associated risk factors.Study Design: A cross-sectional study of 626 street youth, sex workers, and women with social problems or delinquent behavior was conducted.Results: The prevalences of N gonorrhoeae and C trachomatis were, respectively, 1.1% (95% CI, 0.5%-2.3%) and 5.8% (95% CI, 4.1%-7.9%). No significant difference was found between men and women, but the sexually transmitted disease (STD) prevalence was much higher in subjects younger than 20 years: 11.4% versus 3.6% (P < 0.01). In a logistic regression model, factors independently associated with STD infection were age younger than 20 years (OR, 2.6;P = 0.007), occasional sex partners (OR, 2.9;P = 0.007), and injection of drugs (OR, 2.8;P = 0.002) in the preceding 6 months.Conclusions: A moderate STD prevalence was found in the study population. The prevalence, however, can be considered high (>10%) among street youth and young sex workers. Providing community-based STD screening and treatment services appear to be an efficient method for reaching these high-risk groups.
Boily MC, Lowndes CM, Alary M, 2000, Complementary hypothesis concerning the community sexually transmitted disease mass treatment puzzle in Rakai, Uganda, AIDS, Vol: 14, Pages: 2583-2592, ISSN: 0269-9370
BOILY M-C, POULIN R, MÂSSE B, 2000, Some Methodological Issues in the Study of Sexual Networks: From Model to Data to Model, Sexually Transmitted Diseases, Vol: 27, Pages: 558-571
Background: Mixing between sexual activity classes is an important determinant of sexually transmitted disease transmission. However, attempts to estimate sexual mixing patterns in the field remain limited partly because of practical and methodological difficulties.Goal: To evaluate and identify appropriate sampling schemes to estimate the mixing pattern between sexual activity classes from large population networks with one or more components.Study Design: The study is based on simulations of large population networks with various structural characteristics. A variety of snowball sampling schemes are applied to these networks and are evaluated by the quality of the mixing matrix estimates that they produce.Results and Conclusions: Unbiased estimation of mixing patterns (global assortativity, within-group mixing of the lowest activity classes, within-group mixing of the highest activity classes) from large population networks is possible with a snowball sampling design in which the initial sample of index cases is drawn from the general population, all partners of the index case are recruited, and only one generation of partners are traced (one cycle). Simulation techniques proved useful in addressing complex methodological issues in situations where analytic results are difficult to obtain.
POULIN R, Boily MC, Masse B, 2000, Dynamical systems to define centrality in social networks, Social Networks, Vol: 22, Pages: 187-220
In this paper, new measures of centrality that summarize the contact structure of social networks are proposed. The new measures use a cumulative nomination scheme based on the preliminary assumption that more central individuals will be nominated more often. Some of these measures are defined to characterize networks of different sizes and, by extension, networks made of many components. These new measures are applied to a network of 40 homosexuals with AIDS [Auerbach, D., Darrow, W., Jaffe, H., Curran, J., 1984. Cluster of cases of the acquired immune deficiency syndrome: patients linked by sexual contact. Am. J. Med. 76 (1984) 487–492; Klovdahl, A.S., 1985. Social networks and the spread of infectious diseases: the AIDS example. Soc. Sci. Med. 21 (1985) 1203–1216.], an illustrative multi-component network and a simulated network. They are compared to classical measures based on geodesics (closeness, eccentricity), to information-based centrality measures introduced by Stephenson and Zelen [Stephenson, K., Zelen, M., 1989. Rethinking centrality: methods and examples. Soc. Networks 11 (1989) 1–37.] and Altmann [Altmann, M., 1993. Reinterpreting network measures for models of disease transmission. Soc. Networks 15 (1993) 1–17.], and to the centrality measure of Bonacich [Bonacich, P., 1972. Factoring and weighting approaches to status scores and clique identification. J. Math. Sociol. 2 (1972) 113–120.]. The most basic of our measures is shown to be related to the Bonacich index of centrality for connected networks. The scaling law of the different centrality measures is examined by measuring simulated networks of various sizes. Measures based on the distribution of the components' size obey a simple proportional scaling law while those based on geodesics do not. Our new measures prove interesting because they consider all the possible paths, do not require intensive computer calculations, and can be used to compare networks of differen
Brisson M, Boily MC, Masse BR, et al., 1999, Highlights of the sexual activity of the heterosexual population in the province of Quebec, SEXUALLY TRANSMITTED INFECTIONS, Vol: 75, Pages: 296-299, ISSN: 1368-4973
Desai KN, Boily MC, Masse BR, et al., 1999, Simulation studies of phase III clinical trials to test the efficacy of a candidate HIV-1 vaccine, EPIDEMIOLOGY AND INFECTION, Vol: 123, Pages: 65-88, ISSN: 0950-2688
Boily MC, Masse BR, Desai K, et al., 1999, Some important issues in the planning of phase III HIV vaccine efficacy trials, VACCINE, Vol: 17, Pages: 989-1004, ISSN: 0264-410X
Boily MC, Masse BR, Desai K, et al., 1999, Some important issues in the planning of phase III HIV vaccine efficacy trials, Vaccine, Vol: 17:989-1004
Boily MC, Masse B, 1997, Mathematical models of disease transmission: A precious tool for the study of sexually transmitted diseases, CANADIAN JOURNAL OF PUBLIC HEALTH-REVUE CANADIENNE DE SANTE PUBLIQUE, Vol: 88, Pages: 255-265, ISSN: 0008-4263
Boily MC, Anderson RM, 1996, Human immunodeficiency virus transmission and the role of other sexually transmitted diseases - Measures of association and study design, SEXUALLY TRANSMITTED DISEASES, Vol: 23, Pages: 312-332, ISSN: 0148-5717
Boily MC, Brunham R, 1994, Erratum: The impact of HIV and other STDs on human populations: Are predictions possible? (Infectious Disease Clinics of North America (1993)), Infectious Disease Clinics of North America, Vol: 8, ISSN: 0891-5520
BOILY MC, BRUNHAM RC, 1993, THE IMPACT OF HIV AND OTHER STDS ON HUMAN-POPULATIONS - ARE PREDICTIONS POSSIBLE, INFECTIOUS DISEASE CLINICS OF NORTH AMERICA, Vol: 7, Pages: 771-792, ISSN: 0891-5520
Boily MC, 1993, The impact of HIV and other STDs on human populations. Are predictions possible?, Infect Dis Clin North Am., Vol: 4, Pages: 771-92
This article presents an overview of the use of mathematical models to study the demographic impact of STDs. Written for the nonmathematician, the article introduces the basic concepts of mathematical epidemiology for infectious diseases, such as the mass-action principle, the threshold density concept, and the basic reproductive rate. Described are the main features that characterize the epidemiology of STDs and those features that differentiate them from other directly transmitted diseases, such as measles, rubella, and others. Also presented are major findings concerning the importance of sexual behavior on the dynamics of STD transmission, and the numerical analysis of the demographic impact on gonococcal and HIV infections using a mathematical model. The epidemiology of these two STDs is explored, as well as how the growth rate of the population can influence the epidemiology of these STDs. Finally, the authors demonstrate how, under some circumstances, early treatment of gonorrhea can reduce the demographic impact of HIV in regions most affected by both diseases.
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