Publications
291 results found
Orroth KK, Freeman EE, Bakker R, et al., 2007, Understanding the differences between contrasting HIV epidemics in east and west Africa:: results from a simulation model of the Four Cities Study, SEXUALLY TRANSMITTED INFECTIONS, Vol: 83, Pages: I5-I16, ISSN: 1368-4973
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- Citations: 56
Freeman EE, Orroth KK, White RG, et al., 2007, Proportion of new HIV infections attributable to herpes simplex 2 increases over time:: simulations of the changing role of sexually transmitted infections in sub-Saharan African HIV epidemics, SEXUALLY TRANSMITTED INFECTIONS, Vol: 83, Pages: I17-I24, ISSN: 1368-4973
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- Citations: 79
White RG, Cooper BS, Kedhar A, et al., 2007, Quantifying HIV-1 transmission due to contaminated injections, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 104, Pages: 9794-9799, ISSN: 0027-8424
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- Citations: 19
Boily MC, Asghar Z, Garske T, et al., 2007, Influence of Selected Formation Rules for Finite Population Networks with Fixed Macrostructures: Implications for Individual-Based Model of Infectious Diseases, Mathematical Population Studies, Vol: 14, Pages: 237-267
Individual-based network models are increasingly being applied to understand the transmission dynamics of infectious diseases. Research in this area has mostly focused on networks defined under a limited set of rules (e.g., preferential attachment, sexual partner formation and dissolution) that are supposed to mimic the real world but are often defined heuristically due to lack of empirical knowledge. Here, two different mechanisms (M- and λ2-rules) were used to generate a wide range of networks and to show the extent to which microstructures such as the mean component size, the size of the giant component and the cumulative nomination centrality index may vary between networks with fixed predetermined macrostructure characteristics (size, node degree distribution and mixing pattern) and influence disease transmission. It is important to carefully consider the limitations of network models and to appreciate the extent to which a given degree distribution and mixing pattern will be consistent with a wide range of underlying network microstructures.
Van de Velde N, Brisson M, Boily MC, 2007, Modeling human papillomavirus vaccine effectiveness: quantifying the impact of parameter uncertainty, American Journal Epidemioly, Vol: 165, Pages: 762-775
Brisson M, Van de Velde N, Boily MC, 2007, The potential cost-effectiveness of prophylactic human papillomavirus vaccines in Canada, Vaccine, Vol: 25, Pages: 5399-5408
Brisson M, Van de Velde N, Boily MC, 2007, The potential cost-effectiveness of prophylactic human papillomavirus vaccines in Canada, Vaccine, Vol: 25, Pages: 5399-5408
Desai K, Boily MC, Garnett GP, et al., 2006, The role of sexually transmitted infections in male circumcision effectiveness against HIV - insights from clinical trial simulation, Emerging Themes in Epidemiology, Vol: 3, ISSN: 1742-7622
BACKGROUND: A landmark randomised trial of male circumcision (MC) in Orange Farm, South Africa recently showed a large and significant reduction in risk of HIV infection, reporting MC effectiveness of 61% (95% CI: 34%-77%). Additionally, two further randomised trials of MC in Kisumu, Kenya and Rakai, Uganda were recently stopped early to report 53% and 48% effectiveness, respectively. Since MC may protect against both HIV and certain sexually transmitted infections (STI), which are themselves cofactors of HIV infection, an important question is the extent to which this estimated effectiveness against HIV is mediated by the protective effect of circumcision against STI. The answer lies in the trial data if the appropriate statistical analyses can be identified to estimate the separate efficacies against HIV and STI, which combine to determine overall effectiveness. OBJECTIVES AND METHODS: Focusing on the MC trial in Kisumu, we used a stochastic prevention trial simulator (1) to determine whether statistical analyses can validly estimate efficacy, (2) to determine whether MC efficacy against STI alone can produce large effectiveness against HIV and (3) to estimate the fraction of all HIV infections prevented that are attributable to efficacy against STI when both efficacies combine. RESULTS: Valid estimation of separate efficacies against HIV and STI as well as MC effectiveness is feasible with available STI and HIV trial data, under Kisumu trial conditions. Under our parameter assumptions, high overall effectiveness of MC against HIV was observed only with a high MC efficacy against HIV and was not possible on the basis of MC efficacy against STI alone. The fraction of all HIV infections prevented which were attributable to MC efficacy against STI was small, except when efficacy of MC specifically against HIV was very low. In the three MC trials which reported between 48% and 61% effectiveness (combining STI and HIV efficacies), the fraction of HIV infections prevent
Williams JR, Foss AM, Vickerman P, et al., 2006, What is the achievable effectiveness of the India AIDS Initiative intervention among female sex workers under target coverage? Model projections from southern India, SEXUALLY TRANSMITTED INFECTIONS, Vol: 82, Pages: 372-380, ISSN: 1368-4973
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- Citations: 20
Desai K, Boily MC, Masse B, et al., 2006, Using Transmission Dynamics Models to Validate Vaccine Efficacy Measures.Prior to Conducting HIV Vaccine Efficacy Trials., Discrete Epidemiology, Editors: Abello, Cormode, Abello, Eds, Abello, Cormode, Publisher: AMS(American Mathematical Society)-, Pages: 139-162
Baggaley RF, Boily MC, White RG, et al., 2006, Risk of HIV-1 transmission for parenteral exposure and blood transfusion: a systematic review and meta-analysis, AIDS, Vol: 20, Pages: 805-812, ISSN: 0269-9370
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- Citations: 139
Vlahov D, Celentano DD, 2006, Access to highly active antiretroviral therapy for injection drug users: adherence, resistance, and death., Cad Saude Publica, Vol: 22, Pages: 705-718, ISSN: 0102-311X
Injection drug users (IDUs) continue to comprise a major risk group for HIV infection throughout the world and represent the focal population for HIV epidemics in Asia and Eastern Europe/Russia. HIV prevention programs have ranged from HIV testing and counseling, education, behavioral and network interventions, drug abuse treatment, bleach disinfection of needles, needle exchange and expanded syringe access, as well as reducing transition to injection and primary substance abuse prevention. With the advent of highly active antiretroviral therapy (HAART) in 1996, dramatic clinical improvements have been seen. In addition, the treatment's impact on reducing HIV viral load (and therefore transmission by all routes) provides a stronger rationale for an expansion of the focus on prevention to emphasize early identification and treatment of HIV infected individuals. However, treatment of IDUs has many challenges including adherence, resistance and relapse to high risk behaviors, all of which impact issues of access and ultimately effectiveness of potent antiretroviral treatment. A major current challenge in addressing the HIV epidemic revolves around an appropriate approach to HIV treatment for IDUs.
Petersen ML, Boily MC, Bastos FI, 2006, Assessing HIV resistance in developing countries: Brazil as a case study, REVISTA PANAMERICANA DE SALUD PUBLICA-PAN AMERICAN JOURNAL OF PUBLIC HEALTH, Vol: 19, Pages: 146-156, ISSN: 1020-4989
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- Citations: 9
Petersen ML, Boily MC, 2006, Assessing HIV resistance in developing countries: Brazil as a case study., Rev Panam Salud Publica, Vol: 19(3):
Desai K, Boily M-C, Misse B, et al., 2006, Using transmission dynamics models to validate vaccine efficacy measures prior to conducting HIV vaccine efficacy trials, DIMACS Workshop on Data Mining and Epidemiology, Publisher: AMER MATHEMATICAL SOC, Pages: 139-161, ISSN: 1052-1798
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- Citations: 3
Boily MC, Bastos FI, Desai K, et al., 2005, Increasing prevalence of male homosexual partnerships and practices in Britain 1990-2000: but why?, AIDS, Vol: 19, Pages: 352-354, ISSN: 0269-9370
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- Citations: 3
Paz-Bailey G, Rahman M, Chen C, et al., 2005, Changes in the etiology of sexually transmitted diseases in Botswana between 1993 and 2002: implications for the clinical management of genital ulcer disease, Clin Infect Dis., Vol: 41, Pages: 1304-1312, ISSN: 1058-4838
Boily MC, Godin G, Hogben M, et al., 2005, The impact of the transmission dynamics of the HIV/AIDS epidemic on sexual behaviour: A new hypothesis to explain recent increases in risk taking-behaviour among men who have sex with men, MEDICAL HYPOTHESES, Vol: 65, Pages: 215-226, ISSN: 0306-9877
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- Citations: 31
Boily M-C, Hogben M, Sherr L, et al., 2005, The impact of the transmission dynamics of the HIV/AIDS epidemic on sexual behaviour: A new hypothesis to explain recent increases in risk taking-behaviour among men who have sex with men., Medical Hypotheses, Vol: 65(2), Pages: 215-216
Boily MC, Bastos FI, Desai K, et al., 2004, Changes in the transmission dynamics of the HIV epidemic after the wide-scale use of antiretroviral therapy could explain increases in sexually transmitted infections -: Results from mathematical models, SEXUALLY TRANSMITTED DISEASES, Vol: 31, Pages: 100-112, ISSN: 0148-5717
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- Citations: 69
Boily MC, White RG, Alary M, et al., 2004, Transmission of HIV via unsafe injection or unsafe sex? Anomalies or misunderstanding?, INTERNATIONAL JOURNAL OF STD & AIDS, Vol: 15, Pages: 61-63, ISSN: 0956-4624
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- Citations: 4
Bastos FI, Petersen M, Kerrigan D, et al., 2004, La prise en charge des traitements contre le VIH/SIDA. L’esperience bresilienne., Les Antirétroviraux: Expériences et Défis, Editors: Levy, Pierret, Trottier, Publisher: Les Presses de l’Université du Québec, Pages: 195-236
Alary M, Lowndes CA, Boily MC, 2003, Community randomized trials for HIV prevention: the past, a lesson for the future?, AIDS, Vol: 17, Pages: 2661-2663, ISSN: 0269-9370
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- Citations: 9
Alary M, Lowndes CM, Boily MC, 2003, Community randomized trials for HIV prevention: The past, a lesson for the future?, AIDS, Vol: 17, Pages: 2661-2663, ISSN: 0269-9370
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- Citations: 7
Desai K, Boily MC, Garnett GP, et al., 2003, The use of mathematical modeling ot validate statistical power and protective efficacy of circumcision against HIV and STI in a current phase III study in Kisumu, Kenya, 3rd Joint International Conference of ISCB and SCT
Boily MC, Desai K, Masse BR, et al., 2003, The use of transmission dynamics models of infectious diseases to improve clinical trials and public health decisions, . 9th Biennial Symposium on Statistical Methods in Atlanta
Raboud JM, Boily MC, Rajeswaran J, et al., 2003, The impact of needle-exchange programs on the spread of HIV among injection drug users: a simulation study, Conference on Statistics and Health, Publisher: SPRINGER, Pages: 302-320, ISSN: 1099-3460
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- Citations: 21
Boily M-C, White R, Lowndes C, et al., 2003, Transmission of HIV via unsafe injection or unsafe sex? Anomalies or misunderstanding?, Int J of STD&AIDS, Vol: 15, Pages: 61-62
Ghani A, Boily M-C, 2003, The epidemiology of HIV/AIDS: Contributions to infectious diseases epidemiology, LEarning from HIV and AIDS, Editors: Ellison, Parker, Campbell, Publisher: Cambridge University Press, Pages: 59-87
Boily MC, Bastos FI, Mâsse B, 2002, No increase in HIV incidence in a cohort of men who have sex with men in Montreal:: too early to conclude?, AIDS, Vol: 16, Pages: 2502-2503, ISSN: 0269-9370
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- Citations: 1
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