Publications
262 results found
Viessmann OM, Eckersley RJ, Christensen-Jeffries K, et al., 2013, Acoustic super-resolution with ultrasound and microbubbles, PHYSICS IN MEDICINE AND BIOLOGY, Vol: 58, Pages: 6447-6458, ISSN: 0031-9155
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- Citations: 188
Zhou B, Fraser KH, Poelma C, et al., 2013, ULTRASOUND IMAGING VELOCIMETRY: EFFECT OF BEAM SWEEPING ON VELOCITY ESTIMATION, ULTRASOUND IN MEDICINE AND BIOLOGY, Vol: 39, Pages: 1672-1681, ISSN: 0301-5629
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- Citations: 22
Hosny NA, Mohamedi G, Rademeyer P, et al., 2013, Mapping microbubble viscosity using fluorescence lifetime imaging of molecular rotors, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 110, Pages: 9225-9230, ISSN: 0027-8424
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- Citations: 112
Casey J, Sennoga C, Mulvana H, et al., 2013, SINGLE BUBBLE ACOUSTIC CHARACTERIZATION AND STABILITY MEASUREMENT OF ADHERENT MICROBUBBLES, ULTRASOUND IN MEDICINE AND BIOLOGY, Vol: 39, Pages: 903-914, ISSN: 0301-5629
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- Citations: 9
Papadopoulou V, Eckersley RJ, Balestra C, et al., 2013, A critical review of physiological bubble formation in hyperbaric decompression, Advances in Colloid and Interface Science, Vol: 191–192, Pages: 22-30, ISSN: 1873-3727
Fan T, Liu Z, Zhang D, et al., 2013, Comparative Study of Lesions Created by High-Intensity Focused Ultrasound Using Sequential Discrete and Continuous Scanning Strategies, IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, Vol: 60, Pages: 763-769, ISSN: 0018-9294
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- Citations: 14
Owen J, Zhou B, Rademeyer P, et al., 2012, Understanding the structure and mechanism of formation of a new magnetic microbubble formulation, Theranostics, Vol: 2, Pages: 1127-1139, ISSN: 1838-7640
Loughran J, Sennoga C, Eckersley RJ, et al., 2012, Effect of ultrasound on adherent microbubble contrast agents, PHYSICS IN MEDICINE AND BIOLOGY, Vol: 57, Pages: 6999-7014, ISSN: 0031-9155
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- Citations: 4
Poelma C, van der Mijle RME, Mari JM, et al., 2012, Ultrasound imaging velocimetry: Toward reliable wall shear stress measurements, EUROPEAN JOURNAL OF MECHANICS B-FLUIDS, Vol: 35, Pages: 70-75, ISSN: 0997-7546
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- Citations: 41
Mulvana H, Browning RJ, Tang M-X, et al., 2012, ALBUMIN COATED MICROBUBBLE OPTIMIZATION: CUSTOM FABRICATION AND COMPREHENSIVE CHARACTERIZATION, ULTRASOUND IN MEDICINE AND BIOLOGY, Vol: 38, Pages: 1599-1607, ISSN: 0301-5629
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- Citations: 4
Cheng Y, Li R, Li S, et al., 2012, SHEAR WAVE ELASTICITY IMAGING BASED ON ACOUSTIC RADIATION FORCE AND OPTICAL DETECTION, ULTRASOUND IN MEDICINE AND BIOLOGY, Vol: 38, Pages: 1637-1645, ISSN: 0301-5629
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- Citations: 18
Mulvana H, Stride E, Tang M-X, et al., 2012, THE INFLUENCE OF GAS SATURATION ON MICROBUBBLE STABILITY, ULTRASOUND IN MEDICINE AND BIOLOGY, Vol: 38, Pages: 1097-1100, ISSN: 0301-5629
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- Citations: 23
Browning RJ, Mulvana H, Tang M-X, et al., 2012, EFFECT OF ALBUMIN AND DEXTROSE CONCENTRATION ON ULTRASOUND AND MICROBUBBLE MEDIATED GENE TRANSFECTION <i>IN VIVO</i>, ULTRASOUND IN MEDICINE AND BIOLOGY, Vol: 38, Pages: 1067-1077, ISSN: 0301-5629
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- Citations: 13
Loughran J, Eckersley RJ, Tang M-X, 2012, Modeling non-spherical oscillations and stability of acoustically driven shelled microbubbles, JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, Vol: 131, Pages: 4349-4357, ISSN: 0001-4966
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- Citations: 10
Mulvana H, Eckersley RJ, Tang M-X, et al., 2012, THEORETICAL AND EXPERIMENTAL CHARACTERISATION OF MAGNETIC MICROBUBBLES, ULTRASOUND IN MEDICINE AND BIOLOGY, Vol: 38, Pages: 864-875, ISSN: 0301-5629
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- Citations: 27
Sennoga CA, Yeh JSM, Alter J, et al., 2012, EVALUATION OF METHODS FOR SIZING AND COUNTING OF ULTRASOUND CONTRAST AGENTS, ULTRASOUND IN MEDICINE AND BIOLOGY, Vol: 38, Pages: 834-845, ISSN: 0301-5629
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- Citations: 39
Stride E, Owen J, Mulvana H, et al., 2012, Magnetic microbubbles for localised imaging and drug delivery: Development, characterisation and preliminary application in vivo., J Acoust Soc Am, Vol: 131
The use of coated microbubbles in therapeutic applications, in particular drug delivery and gene therapy, has become a highly active area of research. There remain, however, some significant challenges to be overcome in order to fully realise the potential of microbubbles in these applications. In particular, the difficulty in controlling the concentration of microbubbles at a given site and in ensuring sufficient proximity between bubbles and target cells, has frequently led to disappointing results from in vivo studies. Recent work has indicated that incorporating magnetic nanoparticles into the microbubble coating may provide an effective strategy for overcoming these challenges. Further investigation to fully understand the mechanisms of enhancement and hence optimise the delivery protocols is however required and this is the aim of the present study. Results will be presented from flow phantom studies demonstrating manipulation of bubble suspensions under physiological flow conditions, from high speed imaging used to investigate the dynamic behaviour of single microbubbles and theoretical modelling conducted to support and interpret the experimental findings. Finally results demonstrating in vivo transfection in a mouse model will be presented confirming successful localisation of the transfection site.
Song L, Cheng Y, Li R, et al., 2012, Imaging ultrasound field and shear wave propagation using acousto-optic laser speckle contrast analysis (AO-LASCA), Conference on Photons Plus Ultrasound - Imaging and Sensing/Photonics West BiOS Symposium, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X
Stride E, Mulvana H, Eckersley R, et al., 2012, Magnetic Microbubbles, MAGNETIC NANOPARTICLES: FROM FABRICATION TO CLINICAL APPLICATIONS, Editors: Thanh, Publisher: CRC PRESS-TAYLOR & FRANCIS GROUP, Pages: 499-522, ISBN: 978-1-4398-6932-1
Browning RJ, Tang M-X, Eckersley RJ, 2012, The Effect of Glucosamine on the Acoustic and Binding Properties of Albumin-based Microbubbles (Work in Progress), 2012 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), Pages: 2294-2297, ISSN: 1948-5719
Zhang Y-L, Zheng H-R, Tang M-X, et al., 2011, Effect of secondary radiation force on aggregation between encapsulated microbubbles, CHINESE PHYSICS B, Vol: 20, ISSN: 1674-1056
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- Citations: 8
Browning RJ, Mulvana H, Tang M, et al., 2011, INFLUENCE OF NEEDLE GAUGE ON <i>IN VIVO</i> ULTRASOUND AND MICROBUBBLE-MEDIATED GENE TRANSFECTION, ULTRASOUND IN MEDICINE AND BIOLOGY, Vol: 37, Pages: 1531-1537, ISSN: 0301-5629
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- Citations: 18
Mulvana H, Stride E, Tang M, et al., 2011, TEMPERATURE-DEPENDENT DIFFERENCES IN THE NONLINEAR ACOUSTIC BEHAVIOR OF ULTRASOUND CONTRAST AGENTS REVEALED BY HIGH-SPEED IMAGING AND BULK ACOUSTICS, ULTRASOUND IN MEDICINE AND BIOLOGY, Vol: 37, Pages: 1509-1517, ISSN: 0301-5629
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- Citations: 21
Elson DS, Li R, Dunsby C, et al., 2011, Ultrasound-mediated optical tomography: a review of current methods, INTERFACE FOCUS, Vol: 1, Pages: 632-648, ISSN: 2042-8898
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- Citations: 60
Tang M-X, Mulvana H, Gauthier T, et al., 2011, Quantitative contrast-enhanced ultrasound imaging: a review of sources of variability, INTERFACE FOCUS, Vol: 1, Pages: 520-539, ISSN: 2042-8898
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- Citations: 214
Xu S, Dai M, Xu C, et al., 2011, Performance Evaluation of Five Types of Ag/AgCl Bio-Electrodes for Cerebral Electrical Impedance Tomography, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 39, Pages: 2059-2067, ISSN: 0090-6964
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- Citations: 33
Li R, Elson DS, Dunsby C, et al., 2011, Effects of acoustic radiation force and shear waves for absorption and stiffness sensing in ultrasound modulated optical tomography., Opt Express, Vol: 19, Pages: 7299-7311
Ultrasound-modulated optical tomography (UOT) combines optical contrast with ultrasound spatial resolution and has great potential for soft tissue functional imaging. One current problem with this technique is the weak optical modulation signal, primarily due to strong optical scattering in diffuse media and minimal acoustically induced modulation. The acoustic radiation force (ARF) can create large particle displacements in tissue and has been shown to be able to improve optical modulation signals. However, shear wave propagation induced by the ARF can be a significant source of nonlocal optical modulation which may reduce UOT spatial resolution and contrast. In this paper, the time evolution of shear waves was examined on tissue mimicking-phantoms exposed to 5 MHz ultrasound and 532 nm optical radiation and measured with a CCD camera. It has been demonstrated that by generating an ARF with an acoustic burst and adjusting both the timing and the exposure time of the CCD measurement, optical contrast and spatial resolution can be improved by ~110% and ~40% respectively when using the ARF rather than 5 MHz ultrasound alone. Furthermore, it has been demonstrated that this technique simultaneously detects both optical and mechanical contrast in the medium and the optical and mechanical contrast can be distinguished by adjusting the CCD exposure time.
Tang M-X, Loughran J, Stride E, et al., 2011, Effect of bubble shell nonlinearity on ultrasound nonlinear propagation through microbubble populations, JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, Vol: 129, Pages: EL76-EL82, ISSN: 0001-4966
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- Citations: 17
Mahue V, Mari JM, Eckersley RJ, et al., 2011, Comparison of Pulse Subtraction Doppler and Pulse Inversion Doppler, IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, Vol: 58, Pages: 73-81, ISSN: 0885-3010
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- Citations: 8
Mulvana H, Eckersley RJ, Browning R, et al., 2010, Enhanced gene transfection in vivo using magnetic localisation ofultrasound contrast agents: Preliminary results, Proceedings - IEEE Ultrasonics Symposium, Pages: 670-673, ISSN: 1051-0117
In previous work we demonstrated that microbubble mediated gene deliverycan be enhanced in vitro through simultaneous exposure of cells to ultrasoundand magnetic fields in the presence of magnetically loaded microbubbleultrasound contrast agents. The aim of this preliminary study was to investigatethe feasibility of the technique for in vivo applications. Phospholipid coatedmicrobubbles loaded with a hydrocarbon suspension of magnetic nanoparticles wereprepared through sonication and sized using optical microscopy (concentration1.4 108 bubbles/ml). Plasmid pGL4.13, which encodes for fireflyluciferase, was prepared at a concentration of 4 g/l in endotoxin-free water. ASiemens Acuson Sequioa clinical imaging system with a 26 mm linear arraytransducer (15L8) was used throughout the investigation. 20, 6-8 week old CD1female mice were injected with of 150 l of microbubble suspension and 50 lplasmid intra-venously through the tail vein. Mice were anaesthetized usingisoflurance and imaged with the transducer above the left lung (14 MHz, 0.06 MI)to locate the thoracic region. Immediately following injection, a NdFeBpermanent magnet was positioned over the right lung and the acoustic output wasincreased (H7MHz, 1.7 MI, focal depth 7.5 mm). Exposure to ultrasound and/ormagnetic field was maintained for two minutes. 20 mice were exposed toultrasound and magnetic field, two to ultrasound only and two to magnetic fieldonly. On the third day post treatment, luciferase substrate (D-luciferin) wasadministered through intra-peritoneal injection and allowed to catalyse thetransfected substrate for 10 minutes before animals were sacrificed and theirorgans recovered for individual bioluminescence imaging (IVIS 100, Xenogen) andquantification (Living Image Software, Xenogen). Animals treated with bothultrasound and the magnetic field showed transfection in the right lung, whileno animals showed transfection in the contralateral organs. Of the 20 micetreated, 17 showed transfection at a
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