Imperial College London

DrMilesDalby

Faculty of MedicineNational Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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miles.dalby

 
 
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Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
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129 results found

Kalogeras K, Ruparelia N, Kabir T, Jabbour R, Naganuma T, Vavuranakis M, Nakamura S, Wang B, Sen S, Hadjiloizou N, Malik IS, Mikhail G, Dalby M, Panoulas Vet al., 2020, Comparison of the self-expanding Evolut-PRO transcatheter aortic valve to its predecessor Evolut-R in the real world multicenter ATLAS registry, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 310, Pages: 120-125, ISSN: 0167-5273

Journal article

Rathod KS, Beirne A-M, Bogle R, Firoozi S, Lim P, Hill J, Dalby MC, Jain AK, Malik IS, Mathur A, Kalra SS, DeSilva R, Redwood S, MacCarthy PA, Wragg A, Smith EJ, Jones DAet al., 2020, Prior Coronary Artery Bypass Graft Surgery and Outcome After Percutaneous Coronary Intervention: An Observational Study From the Pan-London Percutaneous Coronary Intervention Registry, JOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol: 9, ISSN: 2047-9980

Journal article

Panoulas V, Rathod KS, Jain AK, Firoozi S, Nevett J, Kalra SS, Malik IS, Mathur A, Redwood S, MacCarthy PA, Wragg A, Jones DA, Dalby MCet al., 2020, Impact of early (≤24 h) versus delayed (>24 h) intervention in patients with non-ST segment elevation myocardial infarction: An observational study of 20,882 patients from the London Heart Attack Group., Cardiovasc Revasc Med

INTRODUCTION: We aimed to investigate the optimal timing of invasive coronary angiography and subsequent intervention in non-ST-segment elevation acute myocardial infarction (NSTEMI) patients. METHODS: We examined the impact of early (≤24 h) versus delayed (>24 h) intervention in a large observational cohort of 20,882 consecutive NSTEMI patients treated with PCI between 2005 and 2015 at 8 tertiary cardiac centers in London (UK) using Cox-regression analysis and propensity matching. RESULTS: Mean age was 64.5 ± 12.7 years and 26.1% were females. A quarter (27.6%), were treated within 24 h. Patients treated within 24 h were slightly younger (62.8 ± 12.8 vs. 65.2 ± 12.6, p < 0.001), most commonly male (76% vs. 72.9%, p < 0.001) and were more frequently ventilated (2.3% vs. 1.4%, p < 0.001) and in cardiogenic shock (3.6% vs. 1.4%, p < 0.001) with dynamic changes on their ECG (84.5% vs. 76.1% p < 0.001). At a median follow up of 4.2 years (interquartile range 1.8 to 7) 17.7% of patients had died. Estimated 5-year survival in patients treated within 24 h was 84.6% vs. 81% for those treated >24 h following their presentation (p < 0.001). This survival benefit remained following adjustment for confounders; HR(delayed vs. early management) 1.11 (95%CI 1.003 to 1.23, p = 0.046). In the propensity matched cohort of 4356 patients in each group, there remained a trend for higher survival in the early intervention group (p = 0.061). CONCLUSIONS: Notwithstanding the limitations of the retrospective design, this real-world cohort of NSTEMI patients suggests that an early intervention (≤24 h) may improve mid-term survival.

Journal article

Rathod KS, Jain AK, Firoozi S, Lim P, Boyle R, Nevett J, Dalby MC, Kalra S, Malik IS, Sirker A, Mathur A, Redwood S, MacCarthy PA, Wragg A, Jones DAet al., 2020, Outcome of inter-hospital transfer versus direct admission for primary percutaneous coronary intervention: An observational study of 25,315 patients with ST-elevation myocardial infarction from the London Heart Attack Group, EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE, ISSN: 2048-8726

Journal article

Rathod KS, Koganti S, Jain AK, Rakhit R, Dalby MC, Lockie T, Kalra S, Malik IS, Knight CJ, Whitbread M, Mathur A, Firoozi S, Bogle R, Redwood S, MacCarthy PA, Sirker A, O'Mahony C, Wragg A, Jones DAet al., 2020, Complete Versus Culprit only Revascularisation in Patients with Cardiogenic Shock Complicating Acute Myocardial Infarction: Incidence and Outcomes from the London Heart Attack Group, CARDIOVASCULAR REVASCULARIZATION MEDICINE, Vol: 21, Pages: 350-358, ISSN: 1553-8389

Journal article

Dalby M, 2019, Christmas 2019 and New Year Greetings, EUROPEAN HEART JOURNAL, Vol: 40, Pages: 3875-3878, ISSN: 0195-668X

Journal article

Dowling C, Firoozi S, Panoulas V, Dalby M, Kashyap MN, Kabir T, Kalogeras K, Buch MH, Levy R, Chowdhary S, Saraf S, Roberts D, More R, Wiper A, Abdelaziz HK, Neylon A, Mylotte D, Pisaniello AD, Fraser DGW, Anderson R, Cunnington MS, Malkin CJ, Blackman DJ, Brennan PF, Owens CG, Manoharan G, Spence MS, Brecker SJet al., 2019, Initial experience of a self-expanding transcatheter aortic valve with an outer pericardial wrap: The United Kingdom and Ireland Implanters' registry, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 95, Pages: 1340-1346, ISSN: 1522-1946

Journal article

Panoulas VF, Ilsley CJ, Kalogeras K, Khan H, Vela MM, Dalby M, Kabir T, Smith RD, Mason M, Grocott-Mason R, Cummings I, Luscher TF, Raja SGet al., 2019, Coronary artery bypass confers intermediate-term survival benefit over percutaneous coronary intervention with new-generation stents in real-world patients with multivessel coronary artery disease, including left main disease: a retrospective analysis of 6383 patients, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 56, Pages: 911-918, ISSN: 1010-7940

Journal article

Kalogeras K, Jabbour RJ, Ruparelia N, Watson S, Kabir T, Naganuma T, Vavuranakis M, Nakamura S, Malik IS, Mikhail G, Dalby M, Panoulas Vet al., 2019, Comparison of warfarin versus DOACs in patients with concomitant indication for oral anticoagulation undergoing TAVI; results from the ATLAS registry, JOURNAL OF THROMBOSIS AND THROMBOLYSIS, Vol: 50, Pages: 82-89, ISSN: 0929-5305

Journal article

Beirne A, Rathod K, Jain A, Mathur A, Wragg A, Smith EJ, Jones DA, Kalra S, Malik I, Redwood S, MacCarthy P, Bogle R, Firoozi S, Dalby Met al., 2019, The association between prior coronary artery bypass graft surgery and outcome after percutaneous coronary intervention (PCI): an observational study of 123,780 patients, Congress of the European-Society-of-Cardiology (ESC) / World Congress of Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 4112-4112, ISSN: 0195-668X

Conference paper

Mittal TK, Reichmuth L, Bhattacharyya S, Jain M, Baltabaeva A, Haley SR, Mirsadraee S, Panoulas V, Kabir T, Nicol ED, Dalby M, Long Qet al., 2019, Inconsistency in aortic stenosis severity between CT and echocardiography: prevalence and insights into mechanistic differences using computational fluid dynamics, OPEN HEART, Vol: 6, ISSN: 2053-3624

Journal article

Jones DA, Rathod KS, Koganti S, Lim P, Firoozi S, Bogle R, Jain AK, MacCarthy PA, Dalby MC, Malik IS, Mathur A, DeSilva R, Rakhit R, Kalra SS, Redwood S, Ludman P, Wragg Aet al., 2019, The association between the public reporting of individual operator outcomes with patient profiles, procedural management, and mortality after percutaneous coronary intervention: an observational study from the Pan-London PCI (BCIS) Registry using an interrupted time series analysis, EUROPEAN HEART JOURNAL, Vol: 40, Pages: 2620-2629, ISSN: 0195-668X

Journal article

Dowling C, Firoozi S, Doyle N, Blackman DJ, Malkin CJ, Cunnington MS, Saraf S, Buch MH, Levy R, Chowdhary S, Spence MS, Manoharan G, Owens CG, Brennan PF, Roberts D, More R, Wiper A, Abdelaziz HK, Mylotte D, Neylon A, Martin N, Mercanti F, Dorman S, Panoulas V, Dalby M, Kashyap MN, Kabir T, Kovac J, Kontoprias K, Malik IS, Ghada MW, Sen S, Ruparelia N, Demir OM, Frame A, Uren NG, Anderson R, Rajathurai T, Tapp L, Deegan L, Grech E, Hall I, Neville M, Rampat R, Hildick-Smith D, Mullen M, Kennon S, Chandrala P, Doshi S, Brecker SJet al., 2019, Initial experience of a large, self-expanding, and fully recapturable transcatheter aortic valve: The UK & Ireland Implanters' registry, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 93, Pages: 751-757, ISSN: 1522-1946

Journal article

Kalogeras K, Kabir T, Mittal T, Mirsadraee S, Skondras E, Haley SR, Zuhair M, Vavuranakis M, Tousoulis D, Dalby M, Panoulas Vet al., 2019, Real-world comparison of the new 34 mm self-expandable transcatheter aortic prosthesis Evolut R to its 31 mm core valve predecessor, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 93, Pages: 685-691, ISSN: 1522-1946

Journal article

Rathod KS, Koganti S, Jain AK, Astroulakis Z, Lim P, Rakhit R, Kalra SS, Dalby MC, O'Mahony C, Malik IS, Knight CJ, Mathur A, Redwood S, Sirker A, MacCarthy PA, Smith EJ, Wragg A, Jones DAet al., 2018, Complete Versus Culprit-Only Lesion Intervention in Patients With Acute Coronary Syndromes, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 72, Pages: 1989-1999, ISSN: 0735-1097

Journal article

Patterson T, Perkins A, Perkins GD, Clayton T, Evans R, Nguyen H, Wilson K, Whitbread M, Hughes J, Fothergill RT, Nevett J, Mosweu I, McCrone P, Dalby M, Rakhit R, MacCarthy P, Perera D, Nolan JP, Redwood SRet al., 2018, Rationale and design of: A Randomized tRial of Expedited transfer to a cardiac arrest center for non-ST elevation out-of-hospital cardiac arrest: The ARREST randomized controlled trial, AMERICAN HEART JOURNAL, Vol: 204, Pages: 92-101, ISSN: 0002-8703

Journal article

Broyd CJ, Panoulas V, Mattar W, Akhtar M, Shekarchi-Khanghahi E, Ioannou A, Raja SG, Mason M, Rahman-Haley S, Skondras E, Dalby M, Luscher TF, Kabir Tet al., 2018, Effect of Aortic Valve Calcium Quantity on Outcome After Balloon Aortic Valvuloplasty for Severe Aortic Stenosis, AMERICAN JOURNAL OF CARDIOLOGY, Vol: 122, Pages: 1036-1041, ISSN: 0002-9149

Journal article

Rogers P, Banya W, Kabir T, Panoulas V, Probert H, Prendergast C, Taylor R, Dalby Met al., 2018, Does cardiac rehabilitation improve functional, independence, frailty and emotional outcomes following trans catheter aortic valve replacement?, European-Society-of-Cardiology Congress, Publisher: OXFORD UNIV PRESS, Pages: 1121-1121, ISSN: 0195-668X

Conference paper

Jones DA, Rathod KS, Koganti S, Hamshere S, Astroulakis Z, Lim P, Sirker A, O'Mahony C, Jain AK, Knight CJ, Dalby MC, Malik IS, Mathur A, Rakhit R, Lockie T, Redwood S, MacCarthy PA, Desilva R, Weerackody R, Wragg A, Smith EJ, Bourantas CVet al., 2018, Angiography alone versus angiography plus optical coherence tomography to guide percutaneous coronary intervention: outcomes from the pan-London PCI cohort, JACC: Cardiovascular Interventions, Vol: 11, Pages: 1313-1321, ISSN: 1936-8798

OBJECTIVES: This study aimed to determine the effect on long-term survival of using optical coherence tomography (OCT) during percutaneous coronary intervention (PCI). BACKGROUND: Angiographic guidance for PCI has substantial limitations. The superior spatial resolution of OCT could translate into meaningful clinical benefits, although limited data exist to date about their effect on clinical endpoints. METHODS: This was a cohort study based on the Pan-London (United Kingdom) PCI registry, which includes 123,764 patients who underwent PCI in National Health Service hospitals in London between 2005 and 2015. Patients undergoing primary PCI or pressure wire use were excluded leaving 87,166 patients in the study. The primary endpoint was all-cause mortality at a median of 4.8 years. RESULTS: OCT was used in 1,149 (1.3%) patients, intravascular ultrasound (IVUS) was used in 10,971 (12.6%) patients, and angiography alone in the remaining 75,046 patients. Overall OCT rates increased over time (p < 0.0001), with variation in rates between centers (p = 0.002). The mean stent length was shortest in the angiography-guided group, longer in the IVUS-guided group, and longest in the OCT-guided group. OCT-guided procedures were associated with greater procedural success rates and reduced in-hospital MACE rates. A significant difference in mortality was observed between patients who underwent OCT-guided PCI (7.7%) compared with patients who underwent either IVUS-guided (12.2%) or angiography-guided (15.7%; p < 0.0001) PCI, with differences seen for both elective (p < 0.0001) and acute coronary syndrome subgroups (p = 0.0024). Overall this difference persisted after multivariate Cox analysis (hazard ratio [HR]: 0.48; 95% confidence interval [CI]: 0.26 to 0.81; p = 0.001) and propensity matching (hazard ratio: 0.39; 95% CI: 0.21 to 0.77; p = 0.0008; OCT vs. angiography-alone cohort), with no difference in matched OCT and IVUS cohorts

Journal article

Jones DA, Rathod KS, Pavlidis AN, Gallagher SM, Astroulakis Z, Lim P, Sirker A, Knight CJ, Dalby MC, Malik IS, Mathur A, Rakhit R, Redwood S, MacCarthy PA, Baker C, Desilva R, Di Mario C, Weerackody R, Hill J, Wragg A, Smith EJet al., 2018, Outcomes after chronic total occlusion percutaneous coronary interventions: an observational study of 5496 patients from the Pan-London CTO Cohort., Coron Artery Dis

BACKGROUND: Chronic total occlusions (CTO) are commonly encountered in patients undergoing coronary angiography; however, percutaneous coronary intervention (PCI) is infrequently performed owing to technical difficulty, the perceived risk of complications and a lack of randomized data. The aim of this study was to analyse the frequency and outcomes of CTO-PCI procedures in a large contemporary cohort of successive patients. PATIENTS AND METHODS: We undertook an observational cohort study of 48 234 patients with stable angina of which 5496 (11.4%) procedures were performed for CTOs between 2005 and 2015 at nine tertiary cardiac centres across London, UK. Outcome was assessed by in-hospital major adverse cardiac events and all-cause mortality at a median follow-up of 4.8 years (interquartile range: 2.2-6.4 years). RESULTS: Over time, there was an increase in the proportion of elective PCI procedures performed for CTOs, but no increase in the absolute number. Overall success rates increased over time (74.3% in 2005 to 81.5% in 2015; P=0.0003) despite an increase in case complexity (previous myocardial infarction, diabetes, renal failure, previous coronary artery bypass grafting, peripheral vascular disease and left ventricular impairment) that correlated with procedural advancements. Successful CTO PCI was associated with lower mortality [9.5%, 95% confidence interval (CI): 8.1-11.6 vs. 15.3%, 95% CI: 13.7-20.6, P<0.0001] that persisted after multivariate cox analysis (hazard ratio: 0.37, 95% CI: 0.25-0.62) and propensity matching (hazard ratio=0.36, 95% CI: 0.18-0.73, P=0.0005). CONCLUSION: Successful procedures were associated with lower mortality suggesting that the greater uptake of CTO PCI may improve clinical outcomes in a wider population than are currently being offered therapy.

Journal article

Iqbal MB, Smith RD, Lane R, Patel N, Mattar W, Kabir T, Panoulas V, Mason M, Dalby MC, Grocott-Mason R, Ilsley CDet al., 2018, The prognostic significance of incomplete revascularization and untreated coronary anatomy following percutaneous coronary intervention: An analysis of 6,755 patients with multivessel disease, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 91, Pages: 1229-1239, ISSN: 1522-1946

Journal article

Dalby M, 2018, State of the art in TAVI, EUROPEAN HEART JOURNAL, Vol: 39, Pages: 1878-1881, ISSN: 0195-668X

Journal article

Mittal T, Nicol E, Reichmuth L, Jain M, Baltabaeva A, Rahman-Haley S, Kabir T, Panoulas V, Mirsadraee S, Dalby M, Long Qet al., 2018, INFLUENCE OF FLOW AND VELOCITY PROFILE ON INCONSISTENCY IN ECHOCARDIOGRAPHIC AORTIC VALVE STENOSIS ASSESSMENT: A COMPUTED TOMOGRAPHY AND COMPUTATIONAL FLOW DYNAMICS STUDY, 67th Annual Scientific Session and Expo of the American-College-of-Cardiology (ACC), Publisher: ELSEVIER SCIENCE INC, Pages: 1583-1583, ISSN: 0735-1097

Conference paper

Raja SG, Ilsley C, De Robertis F, Lane R, Kabir T, Bahrami T, Simon A, Popov A, Dalby MC, Mason M, Grocott-Mason R, Smith RD, Iqbal MBet al., 2018, Mid-to-long term mortality following surgical versus percutaneous coronary revascularization stratified according to stent subtype: An analysis of 6,682 patients with multivessel disease, PLOS ONE, Vol: 13, ISSN: 1932-6203

Journal article

Rathod KS, Koganti S, Iqbal MB, Jain AK, Kalra SS, Astroulakis Z, Lim P, Rakhit R, Dalby MC, Lockie T, Malik IS, Knight CJ, Whitbread M, Mathur A, Redwood S, MacCarthy PA, Sirker A, O'Mahony C, Wragg A, Jones DAet al., 2018, Contemporary trends in cardiogenic shock: Incidence, intra-aortic balloon pump utilisation and outcomes from the London Heart Attack Group, EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE, Vol: 7, Pages: 16-27, ISSN: 2048-8726

Journal article

McGarvey M, Ali O, Iqbal MB, Ilsley C, Wong J, Di Mario C, Redwood S, Patterson T, Pennell DJ, Rogers P, Dalby Met al., 2018, A feasibility and safety study of intracoronary hemodilution during primary coronary angioplasty in order to reduce reperfusion injury in myocardial infarction, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 91, Pages: 234-241, ISSN: 1522-1946

Journal article

Patterson T, Perkins GD, Joseph J, Wilson K, Van Dyck L, Robertson S, Nguyen H, McConkey H, Whitbread M, Fothergill R, Nevett J, Dalby M, Rakhit R, MacCarthy P, Perera D, Nolan JP, Redwood SRet al., 2018, A RANDOMISED TRIAL OF EXPEDITED TRANSFER TO A CARDIAC ARREST CENTRE FOR NON-STE OUT-OF-HOSPITAL CARDIAC ARREST: ARREST, Meeting of the British-Cardiovascular-Intervention-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A7-A8, ISSN: 1355-6037

Conference paper

Rogers P, Al-Aidrous S, Banya W, Haley SR, Mittal T, Kabir T, Panoulas V, Raja S, Bhudia S, Probert H, Prendergast C, Spence MS, Davies S, Moat N, Taylor RS, Dalby Met al., 2018, Cardiac rehabilitation to improve health-related quality of life following trans-catheter aortic valve implantation: a randomised controlled feasibility study: RECOVER-TAVI Pilot, ORCA 4, For the Optimal Restoration of Cardiac Activity Group., Pilot Feasibility Stud, Vol: 4, ISSN: 2055-5784

Objectives: Transcatheter aortic valve implantation (TAVI) is often undertaken in the oldest frailest cohort of patients undergoing cardiac interventions. We plan to investigate the potential benefit of cardiac rehabilitation (CR) in this vulnerable population. Design: We undertook a pilot randomised trial of CR following TAVI to inform the feasibility and design of a future randomised clinical trial (RCT). Participants: We screened patients undergoing TAVI at a single institution between June 2016 and February 2017. Interventions: Participants were randomised post-TAVI to standard of care (control group) or standard of care plus exercise-based CR (intervention group). Outcomes: We assessed recruitment and attrition rates, uptake of CR, and explored changes in 6-min walk test, Nottingham Activities of Daily Living, Fried and Edmonton Frailty scores and Hospital Anxiety and Depression Score, from baseline (30 days post TAVI) to 3 and 6 months post randomisation. We also undertook a parallel study to assess the use of the Kansas City Cardiomyopathy Questionnaire (KCCQ) in the post-TAVI population. Results: Of 82 patients screened, 52 met the inclusion criteria and 27 were recruited (3 patients/month). In the intervention group, 10/13 (77%) completed the prescribed course of 6 sessions of CR (mean number of sessions attended 7.5, SD 4.25) over 6 weeks. At 6 months, all participants were retained for follow-up. There was apparent improvement in outcome scores at 3 and 6 months in control and CR groups. There were no recorded adverse events associated with the intervention of CR. The KCCQ was well accepted in 38 post-TAVI patients: mean summary score 72.6 (SD 22.6). Conclusions: We have demonstrated the feasibility of recruiting post-TAVI patients into a randomised trial of CR. We will use the findings of this pilot trial to design a fully powered multicentre RCT to inform the provision of CR and support guideline development to optimise health-r

Journal article

Dowling C, Firoozi S, Doyle N, Spence M, Manoharan G, Owens C, Kashyap M, Kabir T, Panoulas V, Dalby M, Mylotte D, Neylon A, Martin N, Roberts D, More R, Wiper A, Abdelaziz H, Grech E, Hall I, Neville M, Rampat R, Hildick-Smith D, Mullen M, Kennon S, Chandrala P, Anderson RA, Rajathurai T, Tapp L, Deegan L, Doshi S, Kovac J, Kontoprias K, Brecker Set al., 2017, Initial Experience of the Medtronic 34mm Evolut R Valve: The UK & Ireland Implanters' Registry, 29th Annual Symposium on Transcatheter Cardiovascular Therapeutics (TCT), Publisher: ELSEVIER SCIENCE INC, Pages: B263-B263, ISSN: 0735-1097

Conference paper

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