Dr Nick Brooks is a Reader in the Department of Chemistry, Imperial College London.
My group's research focuses on the effect of high pressure on the structure and micromechanics of biological membranes, and dynamic structural changes in membrane based systems. Coupled to these research aims, we have a strong interest in advanced instrumentation and technique development.
I am a leading member of the Membrane Biophysics Platform which is working at the forefront of the emerging field of molecular membrane engineering to design and construct new biologically-inspired materials and devices. We aim to revolutionise the design and fabrication of smart, soft materials and catalyse a paradigm shift in areas such as nanomedicine, bioelectronics, biological computing devices and synthetic organelles.
Much of our work is underpinned by development of new instrumentation (particularly high pressure platforms) to access experiments that were not previously possible. We have developed world-class systems for high pressure and pressure-jump microscopy and this has led to collaborations across the UK, Europe and USA. Having established an internationally leading pressure-jump facility for small angle X-ray diffraction at Diamond Light Source, we have been involved in the development of further related facilities at both Diamond and ESRF as well as a range of synchrotron based sample environments for probing structural changes in soft materials in response to triggers including solvent environment and electric field.
I have a strong interest in teaching and teaching innovation, particularly in the development of resources that encourage and enable students to explore topics themselves from a variety of perspectives. As Head of Physical Chemistry Teaching, I am a member of the Department of Chemistry teaching leadership team and am committed to encouraging spread of best teaching practice.
et al., 2020, Flip-flop asymmetry of cholesterol in model membranes induced by thermal gradients, Soft Matter, Vol:16, ISSN:1744-683X, Pages:5925-5932
et al., 2020, MAS NMR Investigation of Molecular Order in an Ionic Liquid Crystal, Journal of Physical Chemistry B, Vol:124, ISSN:1520-6106, Pages:4975-4988
et al., 2019, Engineering swollen cubosomes using cholesterol and anionic lipids, Langmuir: the Acs Journal of Surfaces and Colloids, Vol:35, ISSN:0743-7463, Pages:16521-16527
et al., 2019, Induction of non-lamellar phases in archaeal lipids at high temperature and high hydrostatic pressure by apolar polyisoprenoids, Bba: Biomembranes, ISSN:0005-2736
et al., 2019, Coupling Phase Behavior of Fatty Acid Containing Membranes to Membrane Bio-Mechanics, Frontiers in Cell and Developmental Biology, Vol:7, ISSN:2296-634X