Imperial College London

Dr Nick Brooks

Faculty of Natural SciencesDepartment of Chemistry

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2677n.brooks Website

 
 
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Location

 

207JMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Shaw:2012:10.1039/c1sm06703f,
author = {Shaw, KP and Brooks, NJ and Clarke, JA and Ces, O and Seddon, JM and Law, RV},
doi = {10.1039/c1sm06703f},
journal = {Soft Matter},
pages = {1070--1078},
title = {Pressure – temperature phase behaviour of natural sphingomyelin extracts},
url = {http://dx.doi.org/10.1039/c1sm06703f},
volume = {8},
year = {2012}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Sphingomyelin is the only sphingolipid occurring naturally in mammalian cells and can form up to 50% of the total phospholipid content of the myelin sheath which surrounds nerves. Having predominantly long, saturated acyl chains, it has a relatively high chain melting temperature and has been strongly associated with formation of lipid microdomains. Here, the lyotropic phase behaviour of sphingomyelin from three different natural sources (bovine brain, egg yolk and milk) in excess water is studied as a function of temperature and pressure by small- and wide-angle X-ray scattering, and solid state NMR. The different hydrocarbon chain length distributions of the three lipid extracts results in significant differences in their gel phase structure; both the bovine brain and egg yolk sphingomyelins can form a ripple gel phase but milk sphingomyelin forms an interdigitated gel phase due to the high degree of chain mismatch in its longer hydrocarbon chain components.
AU - Shaw,KP
AU - Brooks,NJ
AU - Clarke,JA
AU - Ces,O
AU - Seddon,JM
AU - Law,RV
DO - 10.1039/c1sm06703f
EP - 1078
PY - 2012///
SP - 1070
TI - Pressure – temperature phase behaviour of natural sphingomyelin extracts
T2 - Soft Matter
UR - http://dx.doi.org/10.1039/c1sm06703f
UR - http://hdl.handle.net/10044/1/15593
VL - 8
ER -