Imperial College London

Dr Nick Brooks

Faculty of Natural SciencesDepartment of Chemistry

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2677n.brooks Website

 
 
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Location

 

207JMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Furse:2016:10.1016/j.cdc.2016.08.001,
author = {Furse, S and Brooks, NJ and Woscholski, R and Gaffney, PRJ and Templer, RH},
doi = {10.1016/j.cdc.2016.08.001},
journal = {Chemical Data Collections},
pages = {15--20},
title = {Pressure-dependent inverse bicontinuous cubic phase formation in a phosphatidylinositol 4-phosphate/phosphatidylcholine system},
url = {http://dx.doi.org/10.1016/j.cdc.2016.08.001},
volume = {3-4},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - In this paper, we report the inositide-driven formation of an inverse bicontinuous cubic phase with space group Ia3d (QIIG, gyroid phase). The system under study consisted of distearoylphosphatidylinositol 4-phosphate (DSPIP) and dioleoylphosphatidylcholine at a molar ratio of 1:49, with a physiological concentration of magnesium ions at pH 7·4. The behaviour of the system was monitored as a function of temperature and pressure. The formation of the phase with Ia3d geometry was recorded repeatably at high pressure, and occurred more readily at higher temperatures. We conclude that the Ia3d phase formed is a thermodynamically stable structure, and that DSPIP is a potent source of membrane curvature that can drive the formation of mesophases with both 2- and 3D geometry.
AU - Furse,S
AU - Brooks,NJ
AU - Woscholski,R
AU - Gaffney,PRJ
AU - Templer,RH
DO - 10.1016/j.cdc.2016.08.001
EP - 20
PY - 2016///
SN - 2405-8300
SP - 15
TI - Pressure-dependent inverse bicontinuous cubic phase formation in a phosphatidylinositol 4-phosphate/phosphatidylcholine system
T2 - Chemical Data Collections
UR - http://dx.doi.org/10.1016/j.cdc.2016.08.001
UR - http://hdl.handle.net/10044/1/42515
VL - 3-4
ER -