Imperial College London

Dr Nick Brooks

Faculty of Natural SciencesDepartment of Chemistry

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2677n.brooks Website

 
 
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Location

 

207JMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{McCarthy:2017:10.1016/j.cplett.2016.12.041,
author = {McCarthy, NL and Brooks, NJ and Tyler, AII and ElGamacy, M and Welche, P and Payne, MC and Chau, PL},
doi = {10.1016/j.cplett.2016.12.041},
journal = {Chemical Physics Letters},
pages = {21--27},
title = {A combined X-ray scattering and simulation study of halothane in membranes at raised pressures},
url = {http://dx.doi.org/10.1016/j.cplett.2016.12.041},
volume = {671},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Using a combination of high pressure wide angle X-ray scattering exper-iments and molecular dynamics simulations, we probe the e ect of thearchetypal general anaesthetic halothane on the lipid hydrocarbon chainpacking and ordering in model bilayers and the variation in these parame-ters with pressure. Incorporation of halothane into the membrane causes anexpansion of the lipid hydrocarbon chain packing at all pressures but thee ect of halothane incorporation on the hydrocarbon chain order parameteris signi cantly reduced at elevated pressure.
AU - McCarthy,NL
AU - Brooks,NJ
AU - Tyler,AII
AU - ElGamacy,M
AU - Welche,P
AU - Payne,MC
AU - Chau,PL
DO - 10.1016/j.cplett.2016.12.041
EP - 27
PY - 2017///
SN - 0009-2614
SP - 21
TI - A combined X-ray scattering and simulation study of halothane in membranes at raised pressures
T2 - Chemical Physics Letters
UR - http://dx.doi.org/10.1016/j.cplett.2016.12.041
UR - http://www.sciencedirect.com/science/article/pii/S000926141630999X
UR - http://hdl.handle.net/10044/1/43270
VL - 671
ER -