Imperial College London

ProfessorNaomiChayen

Faculty of MedicineDepartment of Surgery & Cancer

Prof Res Fellow - Professor of Biomedical Sciences
 
 
 
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Contact

 

+44 (0)20 7594 3240n.chayen Website

 
 
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Location

 

Office no. 367Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Summary

Naomi Chayen is Head of the Crystallization Group in Computational and Systems Medicine

Research Interests: 

Structural biology and structural genomics/proteomics.

- Crystallization of proteins and other biological molecules of medical interest for the purpose of 3-D structure determination for rational drug design

- Crystallization of proteins related to cancer therapy  

- Analytical studies in order to gain an a fundamental understanding of the crystallization process and apply this knowledge to solve crystallization problems

- Design of new, non-standard methodology for production of high-quality crystals for X-ray crystallography

- Design and application of smart and nano materials for crystallization

- Automation and miniaturization to nano-scale crystallization in high throughput mode

  
Recent Awards

  • Women of Outstanding Achievement for Innovation & Entrepreneurship Commendation (2012) 
  • Innovator of the Year (2011)
  • Investigator of the Year (2011)

Patents

  • Nine patents and several commercial products.

Commercial Products

Selected Publications  

  • Govada L, Leese HS, Saridakis E, Kassen S, Chain B, Khurshid S, Menzel R, Hu S, Shaffer MSP, Chayen NE (2016) Exploring Carbon Nanomaterial Diversity for Nucleation of Protein Crystals, Scientific Reports Nature publishing Group Vol:6, ISSN:2045-2322
  • Leese, H.S., Govada, L., Saridakis, E., Khurshid, S., Menzel, R., Morishita, T., Clancy, A.J., White, E.R.  Chayen, N.E. and Shaffer, M.S.P. (2016) Reductively PEGylated carbon nanomaterials and their use to nucleate 3D protein crystals: a comparison of dimensionality. Chemical Science 7, 2916-2923.
  • Chain B, Arnold J, Akthar S, Brandt M, Davis D, Noursadeghi M, Lapp T, Ji C, Sankuratri S, Zhang Y, Govada L, Saridakis E, Chayen NE (2015) A Linear Epitope in the N-Terminal Domain of CCR5 and Its Interaction with Antibody. PLOS One Vol: 10(6): e0128381
  • Khurshid, S., Govada L. EL- Sharif H.F., Reddy, S.M. and Chayen N.E (2015) Automating the application of smart materials for protein crystallization. Acta Crystallographica D 71, 534-540.
  • Khurshid S, Saridakis E, Govada L, Chayen N. E. (2014) Porous nucleating agents for protein crystallization., Nat Protoc, 9, 1621-1633
  • Saridakis E, Chayen NE. (2013) Imprinted polymers assisting protein crystallization, Trends in Biotechnology, 31, 515-520
  • Kertis F, Khurshid S, Okman O, et al. (2012) Heterogeneous nucleation of protein crystals using nanoporous gold nucleants, Journal of Materials Chemistry, 22, 21928-21934
  • Saridakis, E., Khurshid, S., Govada, L., Phan, Q., Hawkins, D., Crichlow, G. V., Lolis, E., Reddy, S. M. and Chayen, N. E. (2011) Protein crystallization facilitated by molecularly imprinted polymers. PNAS 108, 11081-11086.
  • Macromolecular Crystallization and Crystal Perfection (2010) N.E. Chayen, J.R. Helliwell, and E.H. Snell. Oxford University Press, UK
  • Saridakis, E. and Chayen, N.E. (2009) Towards a ‘Universal’ Nucleant for Protein Crystallization Trends in Biotechnology 27, 99-106.
  • Chayen, N. E. & Saridakis, E. (2008). Protein crystallization: from purified protein to diffraction-quality crystal. Nature Methods 5, 147-153.
  • Helliwell, J. R. & Chayen, N. E. (2007). Crystallography - A down-to-Earth approach. Nature 448, 658-659.
  • Chayen, N. E., Saridakis, E. & Sear, R. P. (2006). Experiment and theory for heterogeneous nucleation of protein crystals in a porous medium. PNAS 103, 597-601.
Govada L, Leese HS, Saridakis E, Kassen S, Chain B, Khurshid S, Menzel R, Hu S, Shaffer MSP, Chayen NE (2016) Exploring Carbon Nanomaterial Diversity for Nucleation of Protein Crystals, Scientific Reports Nature publishing Group Vol:6, ISSN:2045-2322
and
Leese, H.S., Govada, L., Saridakis, E., Khurshid, S., Menzel, R., Morishita, T., Clancy, A.J., White, E.R.  Chayen, N.E. and Shaffer, M.S.P. (2016) Reductively PEGylated carbon nanomaterials and their use to nucleate 3D protein crystals: a comparison of dimensionality. Chemical Science 7, 2916-2923.

Selected Publications

Journal Articles

Govada L, Leese HS, Saridakis E, et al., 2016, Exploring Carbon Nanomaterial Diversity for Nucleation of Protein Crystals, Scientific Reports, Vol:6, ISSN:2045-2322

More Publications