Imperial College London

ProfessorNaomiChayen

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Prof Res Fellow - Professor of Biomedical Sciences
 
 
 
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Contact

 

+44 (0)20 7594 3240n.chayen Website

 
 
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Location

 

Office no. 367Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Summary

Naomi Chayen is Head of the Crystallization Group in Computational and Systems Medicine

Research Interests: 

Structural biology and structural genomics/proteomics.

- Crystallization of proteins and other biological molecules of medical interest for the purpose of 3-D structure determination for rational drug design

- Crystallization of proteins related to cancer therapy  

- Analytical studies in order to gain an a fundamental understanding of the crystallization process and apply this knowledge to solve crystallization problems

- Design of new, non-standard methodology for production of high-quality crystals for X-ray crystallography

- Design and application of smart and nano materials for crystallization

- Automation and miniaturization to nano-scale crystallization in high throughput mode

  
Recent Awards

  • Women of Outstanding Achievement for Innovation & Entrepreneurship Commendation (2012) 
  • Innovator of the Year (2011)
  • Investigator of the Year (2011)

Patents

  • Nine patents and several commercial products.

Commercial Products

Press Report Highlights

Selected Publications

Journal Articles

Ditsiou A, Cilibrasi C, Simigdala N, et al., 2020, The structure-function relationship of oncogenic LMTK3, Science Advances, Vol:6, ISSN:2375-2548

Birtley JR, Alomary M, Zanini E, et al., 2019, Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions, Nature Communications, Vol:10, ISSN:2041-1723

Nanev C, Saridakis E, Govada L, et al., 2019, Hydrophobic Interface-assisted protein crystallization: theory and experiment, ACS Applied Materials & Interfaces, Vol:11, ISSN:1944-8244, Pages:12931-12940

Khurshid S, Govada L, Wills G, et al., 2018, Chlamydia protein Pgp3 studied at high resolution in a new crystal form, Iucrj, Vol:5, ISSN:2052-2525, Pages:439-448

Nanev CN, Saridakis E, Chayen N, 2017, Protein crystal nucleation in pores, Scientific Reports, Vol:7, ISSN:2045-2322

Khurshid S, Saridakis E, Govada L, et al., 2014, Porous nucleating agents for protein crystallization, Nature Protocols, Vol:9, ISSN:1750-2799, Pages:1621-1633

Mckie AB, Vaughan S, Zanini E, et al., 2012, The OPCML Tumor Suppressor Functions as a Cell Surface Repressor–Adaptor, Negatively Regulating Receptor Tyrosine Kinases in Epithelial Ovarian Cancer, Cancer Discovery

Chayen NE, Saridakis E, 2008, Protein crystallization: "From purified protein to diffraction quality crystals", Nature Methods, Pages:147-153

Chayen, N.E., 2004, Turning protein crystallization from an art into a science, Current Opinion in Structural Biology, Vol:14, ISSN:0959-440X, Pages:577-583

More Publications