ProfessorNaomiChayen

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Prof Res Fellow - Professor of Biomedical Sciences

Contact

+44 (0)20 7594 3240n.chayen Website

Location

Office no. 367Sir Alexander Fleming BuildingSouth Kensington Campus

Summary

Naomi Chayen is Head of the Crystallization Group in Computational and Systems Medicine

Research Interests:

Structural biology and structural genomics/proteomics.

- Crystallization of proteins and other biological molecules of medical interest for the purpose of 3-D structure determination for rational drug design

- Crystallization of proteins related to cancer therapy

- Analytical studies in order to gain an a fundamental understanding of the crystallization process and apply this knowledge to solve crystallization problems

- Design of new, non-standard methodology for production of high-quality crystals for X-ray crystallography

- Design and application of smart and nano materials for crystallization

- Automation and miniaturization to nano-scale crystallization in high throughput mode

Recent Awards

Women of Outstanding Achievement for Innovation & Entrepreneurship Commendation (2012)
Innovator of the Year (2011)
Investigator of the Year (2011)

Patents

Nine patents and several commercial products.

Commercial Products

"Chayen Reddy MIP"
"Naomi's Nucleant"
7 commercial kits for crystallization sold by SME's

Press Report Highlights

Selected Publications

Journal Articles

Ditsiou A, Cilibrasi C, Simigdala N, et al.Ditsiou A, Cilibrasi C, Simigdala N, Papakyriakou A, Milton-Harris L, Vella V, Nettleship JE, Lo JH, Soni S, Smbatyan G, Ntavelou P, Gagliano T, Iachini MC, Khurshid S, Simon T, Zhou L, Hassell-Hart S, Carter P, Pearl LH, Owen RL, Owens RJ, Roe SM, Chayen NE, Lenz H-J, Spencer J, Prodromou C, Klinakis A, Stebbing J, Giamas G close, 2020, The structure-function relationship of oncogenic LMTK3, Science Advances, Vol:6, ISSN:2375-2548

Birtley JR, Alomary M, Zanini E, et al.Birtley JR, Alomary M, Zanini E, Antony J, Maben Z, Weaver G, von Arx C, Mura M, Marinho AT, Lu H, Morecroft E, Karali E, Chayen N, Tate E, Jurewicz M, Stern L, Recchi C, Gabra H close, 2019, Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions, Nature Communications, Vol:10, ISSN:2041-1723

Nanev C, Saridakis E, Govada L, et al.Nanev C, Saridakis E, Govada L, Kassen SC, Solomon HV, Chayen NE close, 2019, Hydrophobic Interface-assisted protein crystallization: theory and experiment, ACS Applied Materials & Interfaces, Vol:11, ISSN:1944-8244, Pages:12931-12940

Khurshid S, Govada L, Wills G, et al.Khurshid S, Govada L, Wills G, McClure M, Helliwell J, Chayen N close, 2018, Chlamydia protein Pgp3 studied at high resolution in a new crystal form, Iucrj, Vol:5, ISSN:2052-2525, Pages:439-448

Nanev CN, Saridakis E, Chayen N, 2017, Protein crystal nucleation in pores, Scientific Reports, Vol:7, ISSN:2045-2322

Khurshid S, Saridakis E, Govada L, et al.Khurshid S, Saridakis E, Govada L, Chayen NE close, 2014, Porous nucleating agents for protein crystallization, Nature Protocols, Vol:9, ISSN:1750-2799, Pages:1621-1633

Mckie AB, Vaughan S, Zanini E, et al.Mckie AB, Vaughan S, Zanini E, Okon IS, Louis L, de Sousa C, Greene MI, Wang Q, Agarwal R, Shaposhnikov D, Wong JLS, Gungor H, Janczar S, El-Bahrawy M, Lam E-F, Chayen NE, Gabra H close, 2012, The OPCML Tumor Suppressor Functions as a Cell Surface Repressor–Adaptor, Negatively Regulating Receptor Tyrosine Kinases in Epithelial Ovarian Cancer, Cancer Discovery

Chayen NE, Saridakis E, 2008, Protein crystallization: "From purified protein to diffraction quality crystals", Nature Methods, Pages:147-153

Chayen, N.E., 2004, Turning protein crystallization from an art into a science, Current Opinion in Structural Biology, Vol:14, ISSN:0959-440X, Pages:577-583

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