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@article{Wyres:2012:infdis/jis703,
author = {Wyres, KL and Lambertsen, LM and Croucher, NJ and McGee, L and von, Gottberg A and Linares, J and Jacobs, MR and Kristinsson, KG and Beall, BW and Klugman, KP and Parkhill, J and Hakenbeck, R and Bentley, SD and Brueggemann, AB},
doi = {infdis/jis703},
journal = {JOURNAL OF INFECTIOUS DISEASES},
pages = {439--449},
title = {Pneumococcal Capsular Switching: A Historical Perspective},
url = {http://dx.doi.org/10.1093/infdis/jis703},
volume = {207},
year = {2012}
}

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TY  - JOUR
AB  - Background.Changes in serotype prevalence among pneumococcal populations result from both serotypereplacement and serotype (capsular) switching. Temporal changes in serotype distributions are well documented,but the contribution of capsular switching to such changes is unknown. Furthermore, it is unclear to what extentvaccine-induced selective pressures drive capsular switching.Methods.Serotype and multilocus sequence typing data for 426 pneumococci dated from 1937 through 2007 wereanalyzed. Whole-genome sequence data for a subset of isolates were used to investigate capsular switching events.Results.We identified 36 independent capsular switch events, 18 of which were explored in detail with whole-genome sequence data. Recombination fragment lengths were estimated for 11 events and ranged from approximately19.0 kb to≥58.2 kb. Two events took place no later than 1960, and the imported DNA included the capsular locusand the nearby penicillin-binding protein genespbp2xandpbp1a.Conclusions.Capsular switching has been a regular occurrence among pneumococcal populations throughout thepast 7 decades. Recombination of large DNA fragments (>30 kb), sometimes including the capsular locus and penicil-lin-binding protein genes, predated both vaccine introduction and widespread antibiotic use. This type of recombina-tion has likely been an intrinsic feature throughout the history of pneumococcal evolution.
AU  - Wyres,KL
AU  - Lambertsen,LM
AU  - Croucher,NJ
AU  - McGee,L
AU  - von,Gottberg A
AU  - Linares,J
AU  - Jacobs,MR
AU  - Kristinsson,KG
AU  - Beall,BW
AU  - Klugman,KP
AU  - Parkhill,J
AU  - Hakenbeck,R
AU  - Bentley,SD
AU  - Brueggemann,AB
DO  - infdis/jis703
EP  - 449
PY  - 2012///
SN  - 0022-1899
SP  - 439
TI  - Pneumococcal Capsular Switching: A Historical Perspective
T2  - JOURNAL OF INFECTIOUS DISEASES
UR  - http://dx.doi.org/10.1093/infdis/jis703
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000313216300011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/57198
VL  - 207
ER  -

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