Dr Neil Dufton

Faculty of Medicine, National Heart & Lung Institute

Honorary Research Associate

Contact

+44 (0)20 7594 2728n.dufton

Location

525W5ICTEM buildingHammersmith Campus

Summary

Career Summary

Neil Dufton graduated from the University of Bath with a BSc (Hon) Pharmacology in 2006. He went on to undertake a PhD at the William Harvey Research Institute within the Bart's and the London Medical School with Professors Perretti and Flower. The project focused on the interaction of the anti-inflammatory protein Annexin 1 with its receptor FPR2/ALX in regulating innate immunology and the resolution of inflammation.

In 2010 he moved to Canada for two years to work with Professor John Wallace at the Farncombe Family Digestive Health Research Institute, McMaster University investigating the role of hydrogen sulfide gas in regulating inflammation.

Neil became a post-doctoral research associate at the National Heart and Lung Institute (NHLI) at Imperial College London in 2012 with Prof. Anna Randi. Neil's current research interests include vascular inflammation, endothelial homeostasis and angiogenesis.

Widefield imaging of whole heart slices

Illustration and Public engagement

Neil has a keen interest communicating his research through art and public engagement projects. Neil has been shortlisted for a number of imaging competitions, winning two and has an image published in the National Geographic (March 2018). He also has two of his illustrations curated by the Wellcome Image Collection.

Microvascular network in the heart (BHF imaging awards 2018)

At the NHLI he is actively involved with public engagement as scientific consultant on an interactive exhibit Blood Lines and the Heart and Lung Repair Shop (click on the link to see his shop demo about blood vessel growth). Outside of Imperial Neil has worked with animators Genetic Moo to develop at interactive blister model as part of Silent Signals a Wellcome Trust funded project produced by Animate. In 2018 Neil setup the I Cell project that will look to utilise imagery, symbols and emojis to help communicate scientific research.

http://wwwf.imperial.ac.uk/blog/imperial-medicine/author/ndufton/

Publications

Journals

Peghaire C, Dufton N, Lang M, et al.Peghaire C, Dufton N, Lang M, Salles I, Ahnstroem J, Kalna V, Raimondi C, Pericleous C, Inuabasi L, Kiseleva R, Muzykantov V, Mason J, Birdsey G, Randi A close, 2019, The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature, Nature Communications, Vol:10, ISSN:2041-1723, Pages:1-17

Issitt T, Bosseboeuf E, De Winter N, et al.Issitt T, Bosseboeuf E, De Winter N, Dufton N, Gestri G, Senatore V, Chikh A, Randi AM, Raimondi C close, 2019, Neuropilin-1 controls endothelial homeostasis by regulating mitochondrial function and iron-dependent oxidative stress via ABCB8, Iscience, Vol:11, ISSN:2589-0042, Pages:205-223

Nowak-Sliwinska P, Alitalo K, Allen E, et al.Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt S-M, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson A-K, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW close, 2018, Consensus guidelines for the use and interpretation of angiogenesis assays, Angiogenesis, Vol:21, ISSN:0969-6970, Pages:425-532

Dufton NP, peghaire CR, Osuna-Almagro L, et al.Dufton NP, peghaire CR, Osuna-Almagro L, Raimondi C, Kalna V, Chuahan A, Webb G, Yang Y, Birdsey GM, Lalor P, Mason JC, Adams D, Randi AM close, 2017, Dynamic regulation of canonical TGFβ signaling by endothelial transcription factor ERG protects from liver fibrogenesis, Nature Communications, Vol:8, ISSN:2041-1723, Pages:1-14

Perbellini F, Watson SA, Scigliano M, et al.Perbellini F, Watson SA, Scigliano M, Alayoubi S, Tkach S, Bardi I, Quaife N, Kane C, Dufton NP, Simon A, Sikkel MB, Faggian G, Randi AM, Gorelik J, Harding S, Terracciano CMN close, 2017, Investigation of cardiac fibroblasts using myocardial slices, Cardiovascular Research, Vol:114, ISSN:1755-3245, Pages:77-89

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