Imperial College London

professor neil fairweather

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Microbiology
 
 
 
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Contact

 

+44 (0)20 7594 5247n.fairweather

 
 
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Location

 

1.44Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

125 results found

Calabi E, Ward S, Wren B, Paxton T, Panico M, Morris H, Dell A, Dougan G, Fairweather Net al., 2001, Molecular characterization of the surface layer proteins from Clostridium difficile, MOLECULAR MICROBIOLOGY, Vol: 40, Pages: 1187-1199, ISSN: 0950-382X

JOURNAL ARTICLE

Fotinou C, Emsley P, Black I, Ando H, Ishida H, Kiso M, Sinha KA, Fairweather NF, Isaacs NWet al., 2001, The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 276, Pages: 32274-32281, ISSN: 0021-9258

JOURNAL ARTICLE

Emsley P, Fotinou C, Black I, Fairweather NF, Charles IG, Watts C, Hewitt E, Isaacs NWet al., 2000, The structures of the H-C fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 275, Pages: 8889-8894, ISSN: 0021-9258

JOURNAL ARTICLE

Farrar JJ, Yen LM, Cook T, Fairweather N, Binh N, Parry J, Parry CMet al., 2000, Tetanus, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 69, Pages: 292-301, ISSN: 0022-3050

JOURNAL ARTICLE

Figueiredo DM, Matthews CC, Parks DA, Fairweather NF, Dougan G, Wilt SG, Fishman PSet al., 2000, Interaction of tetanus toxin derived hybrid proteins with neuronal cells, JOURNAL OF NATURAL TOXINS, Vol: 9, Pages: 363-379, ISSN: 1058-8108

JOURNAL ARTICLE

Matthews CC, Figueiredo DM, Wollack JB, Fairweather NF, Dougan G, Hallewell RA, Cadet JL, Fishman PSet al., 2000, Protective effect of supplemental superoxide dismutase on survival of neuronal cells during starvation - Requirement for cytosolic distribution, JOURNAL OF MOLECULAR NEUROSCIENCE, Vol: 14, Pages: 155-166, ISSN: 0895-8696

JOURNAL ARTICLE

Schneider H, Groves M, Muhle C, Reynolds PN, Knight A, Themis M, Carvajal J, Scaravilli F, Curiel DT, Fairweather NF, Coutelle Cet al., 2000, Retargeting of adenoviral vectors to neurons using the H(c) fragment of tetanus toxin, GENE THERAPY, Vol: 7, Pages: 1584-1592, ISSN: 0969-7128

JOURNAL ARTICLE

Sinha K, Box M, Lalli G, Schiavo G, Schneider H, Groves M, Siligardi G, Fairweather Net al., 2000, Analysis of mutants of tetanus toxin H(C) fragment: ganglioside binding, cell binding and retrograde axonal transport properties, MOLECULAR MICROBIOLOGY, Vol: 37, Pages: 1041-1051, ISSN: 0950-382X

JOURNAL ARTICLE

Sinha K, Box M, Lalli G, Schiavo G, Schneider H, Groves M, Siligardi G, Fairweather Net al., 2000, Analysis of mutants of tetanus toxin H(C) fragment: ganglioside binding, cell binding and retrograde axonal transport properties (vol 37, pg 1041, 2000), MOLECULAR MICROBIOLOGY, Vol: 38, Pages: 916-916, ISSN: 0950-382X

JOURNAL ARTICLE

Stratford R, Douce G, Zhang-Barber L, Fairweather N, Eskola J, Dougan Get al., 2000, Influence of codon usage on the immunogenicity of a DNA vaccine against tetanus, VACCINE, Vol: 19, Pages: 810-815, ISSN: 0264-410X

JOURNAL ARTICLE

Knight A, Carvajal J, Schneider H, Coutelle C, Chamberlain S, Fairweather Net al., 1999, Non-viral neuronal gene delivery mediated by the H-C fragment of tetanus toxin, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 259, Pages: 762-769, ISSN: 0014-2956

JOURNAL ARTICLE

Rice J, King CA, Spellerberg MB, Fairweather N, Stevenson FKet al., 1999, Manipulation of pathogen-derived genes to influence antigen presentation via DNA vaccines, VACCINE, Vol: 17, Pages: 3030-3038, ISSN: 0264-410X

JOURNAL ARTICLE

Watts C, Antoniou A, Manoury B, Hewitt EW, McKay LM, Grayson L, Fairweather NF, Emsley P, Isaacs N, Simitsek PDet al., 1998, Modulation by epitope-specific antibodies of class II MHC-restricted presentation of the tetanus toxin antigen, IMMUNOLOGICAL REVIEWS, Vol: 164, Pages: 11-16, ISSN: 0105-2896

JOURNAL ARTICLE

Anderson R, Gao XM, Papakonstantinopoulou A, Fairweather N, Roberts M, Dougan Get al., 1997, Immunization of mice with DNA encoding fragment C of tetanus toxin, VACCINE, Vol: 15, Pages: 827-829, ISSN: 0264-410X

JOURNAL ARTICLE

Figueiredo DM, Hallewell RA, Chen LL, Fairweather NF, Dougan G, Savitt JM, Parks DA, Fishman PSet al., 1997, Delivery of recombinant tetanus-superoxide dismutase proteins to central nervous system neurons by retrograde axonal transport, EXPERIMENTAL NEUROLOGY, Vol: 145, Pages: 546-554, ISSN: 0014-4886

JOURNAL ARTICLE

Emsley P, Charles IG, Fairweather NF, Isaacs NWet al., 1996, Structure of Bordetella pertussis virulence factor P.69 pertactin, NATURE, Vol: 381, Pages: 90-92, ISSN: 0028-0836

JOURNAL ARTICLE

FIGUEIREDO D, TURCOTTE C, FRANKEL G, LI Y, DOLLY O, WILKIN G, MARRIOTT D, FAIRWEATHER N, DOUGAN Get al., 1995, CHARACTERIZATION OF RECOMBINANT TETANUS TOXIN DERIVATIVES SUITABLE FOR VACCINE DEVELOPMENT, INFECTION AND IMMUNITY, Vol: 63, Pages: 3218-3221, ISSN: 0019-9567

JOURNAL ARTICLE

Harwood G, Lockyer M, Giles H, Fairweather Net al., 1995, Cloning and characterisation of the rabbit 5-HT1D alpha and 5-HT1D beta receptors, FEBS LETTERS, Vol: 377, Pages: 73-76, ISSN: 0014-5793

JOURNAL ARTICLE

SIMITSEK PD, CAMPBELL DG, LANZAVECCHIA A, FAIRWEATHER N, WATTS Cet al., 1995, MODULATION OF ANTIGEN-PROCESSING BY BOUND ANTIBODIES CAN BOOST OR SUPPRESS CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX PRESENTATION OF DIFFERENT T-CELL DETERMINANTS, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 181, Pages: 1957-1963, ISSN: 0022-1007

JOURNAL ARTICLE

BARBEY C, TIERCY JM, FAIRWEATHER N, NIEMANN H, SEGER R, CORRADIN Get al., 1994, PROCESSING AND PRESENTATION OF TETANUS TOXIN BY ANTIGEN-PRESENTING CELLS FROM PATIENTS WITH CHRONIC GRANULOMATOUS-DISEASE (CGD) TO HUMAN SPECIFIC T-CELL CLONES ARE NOT IMPAIRED, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 95, Pages: 227-231, ISSN: 0009-9104

JOURNAL ARTICLE

CHARLES I, FAIRWEATHER N, PICKARD D, BEESLEY J, ANDERSON R, DOUGAN G, ROBERTS Met al., 1994, EXPRESSION OF THE BORDETELLA-PERTUSSIS P.69 PERTACTIN ADHESIN IN ESCHERICHIA-COLI - FATE OF THE CARBOXY-TERMINAL DOMAIN, MICROBIOLOGY-UK, Vol: 140, Pages: 3301-3308, ISSN: 1350-0872

JOURNAL ARTICLE

Charles I, Fairweather N, Pickard D, Beesley J, Anderson R, Dougan G, Roberts Met al., 1994, Expression of the Bordetella pertussis P.69 pertactin adhesin in Escherichia coli: fate of the carboxy-terminal domain., Microbiology, Vol: 140 ( Pt 12), Pages: 3301-3308, ISSN: 1350-0872

The mature pertactin protein (P.69) of Bordetella pertussis can be isolated from the bacterial cell surface as a polypeptide with an apparent molecular mass of 69,000 Da as determined by sodium dodecyl sulphate gel electrophoresis. However the open reading frame of prn, the pertactin gene, encodes a polypeptide with a predicted molecular mass of 93,478 Da, referred to as P.93. Expression of the prn gene in Escherichia coli leads to the synthesis of the full-length P.93 polypeptide, which is rapidly processed to the mature P.69 protein located at the cell surface. The P.93 precursor polypeptide is processed at both termini. A 34 amino acid long signal sequence is removed from the amino-terminus and a polypeptide sequence of about 30,000 Da (P.30) is cleaved from the carboxy-terminus. Deletion of the 3' region of prn, encoding P.30, results in the expression of an intracellular form of P.69. Antiserum which recognizes P.30 was raised using synthetic peptides based on the primary amino acid sequence of the region. This anti-P.30 serum was used in a Western blot analysis of fractionated cells of B. pertussis and E. coli harbouring the intact prn gene. The P.30 polypeptide was readily detected in outer membrane fractions prepared from both of these bacterial species, although it could not be shown to be exposed at the cell surface.

JOURNAL ARTICLE

DOUCE G, CROPLEY I, ROBERTS M, FAIRWEATHER N, CHATFIELD S, DOUGAN Get al., 1994, A ROLE FOR TOXINS IN THE DEVELOPMENT OF ORAL VACCINES, 6th European Workshop on Bacterial Protein Toxins, Publisher: GUSTAV FISCHER VERLAG, Pages: 474-483, ISSN: 0172-5629

CONFERENCE PAPER

EMSLEY P, MCDERMOTT G, CHARLES IG, FAIRWEATHER NF, ISAACS NWet al., 1994, CRYSTALLOGRAPHIC CHARACTERIZATION OF PERTACTIN, A MEMBRANE-ASSOCIATED PROTEIN FROM BORDETELLA-PERTUSSIS, JOURNAL OF MOLECULAR BIOLOGY, Vol: 235, Pages: 772-773, ISSN: 0022-2836

JOURNAL ARTICLE

FAIRWEATHER N, BELL C, COCHRANE S, CHELLY J, WANG S, MOSTACCIUOLO ML, MONACO AP, HAITES NEet al., 1994, MUTATIONS IN THE CONNEXIN-32 GENE IN X-LINKED DOMINANT CHARCOT-MARIE-TOOTH DISEASE (CMTX1), HUMAN MOLECULAR GENETICS, Vol: 3, Pages: 29-34, ISSN: 0964-6906

JOURNAL ARTICLE

KHAN CMA, VILLARREALRAMOS B, PIERCE RJ, RIVEAU G, DEHORMAECHE RD, MCNEILL H, ALI T, FAIRWEATHER N, CHATFIELD S, CAPRON A, DOUGAN G, HORMAECHE CEet al., 1994, CONSTRUCTION, EXPRESSION, AND IMMUNOGENICITY OF THE SCHISTOSOMA-MANSONI P-28 GLUTATHIONE-S-TRANSFERASE AS A GENETIC FUSION TO TETANUS TOXIN FRAGMENT-C IN A LIVE ARO ATTENUATED VACCINE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 91, Pages: 11261-11265, ISSN: 0027-8424

JOURNAL ARTICLE

LI Y, FORAN P, FAIRWEATHER NF, DEPAIVA A, WELLER U, DOUGAN G, DOLLY JOet al., 1994, A SINGLE MUTATION IN THE RECOMBINANT LIGHT-CHAIN OF TETANUS TOXIN ABOLISHES ITS PROTEOLYTIC ACTIVITY AND REMOVES THE TOXICITY SEEN AFTER RECONSTITUTION WITH NATIVE HEAVY-CHAIN, BIOCHEMISTRY, Vol: 33, Pages: 7014-7020, ISSN: 0006-2960

JOURNAL ARTICLE

Makoff AJ, Charles IG, Fairweather NF, 1994, Recombinant antigens as components of a diphtheria-tetanus-pertussis vaccine., Bioprocess Technol, Vol: 19, Pages: 205-231, ISSN: 0888-7470

JOURNAL ARTICLE

ANDERSON MD, FAIRWEATHER N, CHARLES IG, EMSLEY P, ISAACS NW, MACDERMOTT Get al., 1993, CRYSTALLOGRAPHIC CHARACTERIZATION OF TETANUS TOXIN FRAGMENT-C, JOURNAL OF MOLECULAR BIOLOGY, Vol: 230, Pages: 673-674, ISSN: 0022-2836

JOURNAL ARTICLE

CHARLES I, RODGERS B, MUSGRAVE S, PEAKMAN TC, CHUBB A, FAIRWEATHER N, DOUGAN G, ROBERTS Met al., 1993, EXPRESSION OF P.69/PERTACTIN FROM BORDETELLA-PERTUSSIS IN A BACULOVIRUS/INSECT CELL EXPRESSION SYSTEM - PROTECTIVE PROPERTIES OF THE RECOMNBINANT PROTEIN, RESEARCH IN MICROBIOLOGY, Vol: 144, Pages: 681-690, ISSN: 0923-2508

JOURNAL ARTICLE

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